{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:59:59Z","timestamp":1791273599786,"version":"4.1.0"},"reference-count":65,"publisher":"Japan Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1507\/endocrj.kr-106","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T05:48:56Z","timestamp":1189662536000},"page":"497-505","source":"Crossref","is-referenced-by-count":47,"title":["Avenues of Communication between the Brain and Tissues\/Organs Involved in Energy Homeostasis"],"prefix":"10.1507","volume":"54","author":[{"given":"Tetsuya","family":"YAMADA","sequence":"first","affiliation":[{"name":"Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine"},{"name":"Department of Diabetes and Metabolism, Tohoku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"KATAGIRI","sequence":"additional","affiliation":[{"name":"Division of Advanced Therapeutics for Metabolic Diseases, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine"},{"name":"Department of Diabetes and Metabolism, Tohoku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01081-X"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1471-4159.1987.tb01021.x","volume":"49","year":"1987","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Rapoport SI (1996) In vivo labeling of brain phospholipids by long-chain fatty acids: relation to turnover and function. Lipids 31 (Suppl): S97-101.","DOI":"10.1007\/BF02637059"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wang R, <i>et al.<\/i> (2006) Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels. J Neurophysiol 95: 1491-1498.","DOI":"10.1152\/jn.00697.2005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Obici S, <i>et al.<\/i> (2002) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51: 271-275.","DOI":"10.2337\/diabetes.51.2.271"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Obici S, <i>et al.<\/i> (2003) Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 9: 756-761.","DOI":"10.1038\/nm873"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Pocai A, <i>et al.<\/i> (2005) A brain-liver circuit regulates glucose homeostasis. Cell Metab 1: 53-61.","DOI":"10.1016\/j.cmet.2004.11.001"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hu Z, <i>et al.<\/i> (2003) Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci USA 100: 12624-12629.","DOI":"10.1073\/pnas.1834402100"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/nature02440"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300557200"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03267-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124147"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.012"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03292.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Levin BE, <i>et al.<\/i> (2004) Neuronal glucosensing: what do we know after 50 years? Diabetes 53: 2521-2528.","DOI":"10.2337\/diabetes.53.10.2521"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Arluison M, <i>et al.<\/i> (2004) Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain &mdash; an immunohistochemical study. J Chem Neuroanat 28: 117-136.","DOI":"10.1016\/j.jchemneu.2004.05.009"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Arluison M, et al. (2004) Immunocytochemical localization of the glucose transporter 2 (GLUT2) in the adult rat brain. II. Electron microscopic study. J Chem Neuroanat 28: 137-146.","DOI":"10.1016\/j.jchemneu.2004.06.002"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sutherland VL, et al. (2005) Developmental expression of glucokinase in rat hypothalamus. Brain Res Dev Brain Res 154: 255-258.","DOI":"10.1016\/j.devbrainres.2004.11.001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02914.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kang L, <i>et al.<\/i> (2004) Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 53: 549-559.","DOI":"10.2337\/diabetes.53.3.549"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wang R, <i>et al.<\/i> (2004) The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 53: 1959-1965.","DOI":"10.2337\/diabetes.53.8.1959"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Prodi E, Obici S (2006) Minireview: the brain as a molecular target for diabetic therapy. Endocrinology 147: 2664-2669.","DOI":"10.1210\/en.2006-0143"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Plum L, Belgardt BF, Bruning JC (2006) Central insulin action in energy and glucose homeostasis. J Clin Invest 116: 1761-1766.","DOI":"10.1172\/JCI29063"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/nature03439"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Inoue H, <i>et al.<\/i> (2006) Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 3: 267-275.","DOI":"10.1016\/j.cmet.2006.02.009"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770.","DOI":"10.1038\/27376"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Bates SH, Myers MG (2004) The role of leptin &mdash; STAT3 signaling in neuroendocrine function: an integrative perspective. J Mol Med 82: 12-20.","DOI":"10.1007\/s00109-003-0494-z"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32686"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Niswender KD, <i>et al.<\/i> (2001) Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413: 794-795.","DOI":"10.1038\/35101657"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Qi Y, <i>et al.<\/i> (2004) Adiponectin acts in the brain to decrease body weight. Nat Med 10: 524-529.","DOI":"10.1038\/nm1029"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109951"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Shimazu T (1981) Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia 20 (Suppl): 343-356.","DOI":"10.1007\/BF00254502"},{"key":"33","unstructured":"33. Bartness TJ, Bamshad M (1998) Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol 275 (5 Pt 2): R1399-1411."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Imai J, <i>et al.<\/i> (2006) Cold exposure suppresses serum adiponectin levels through sympathetic nerve activation in mice. Obesity (Silver Spring) 14: 1132-1141.","DOI":"10.1038\/oby.2006.130"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Kreier F, <i>et al.<\/i> (2002) Selective parasympathetic innervation of subcutaneous and intra-abdominal fat &mdash; functional implications. J Clin Invest 110: 1243-1250.","DOI":"10.1172\/JCI0215736"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Niijima A (1998) Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat. J Auton Nerv Syst 73: 19-25.","DOI":"10.1016\/S0165-1838(98)00109-X"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Tanida M, <i>et al.<\/i> (2000) Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats. Neurosci Lett 293: 107-110.","DOI":"10.1016\/S0304-3940(00)01490-7"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Kreier F, <i>et al.<\/i> (2006) Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 147: 1140-1147.","DOI":"10.1210\/en.2005-0667"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Yamada T, <i>et al.<\/i> (2006) Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation. Cell Metab 3: 223-229.","DOI":"10.1016\/j.cmet.2006.02.001"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Thorens B, Larsen PJ (2004) Gut-derived signaling molecules and vagal afferents in the control of glucose and energy homeostasis. Curr Opin Clin Nutr Metab Care 7: 471-478.","DOI":"10.1097\/01.mco.0000134368.91900.84"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Strader AD, Woods SC (2005) Gastrointestinal hormones and food intake. Gastroenterology 128: 175-191.","DOI":"10.1053\/j.gastro.2004.10.043"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Havel PJ (2001) Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood) 226: 963-977.","DOI":"10.1177\/153537020122601102"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85: 495-522.","DOI":"10.1152\/physrev.00012.2004"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1126\/science.7268408"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1266"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Abbott CR, <i>et al.<\/i> (2005) The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044: 127-131.","DOI":"10.1016\/j.brainres.2005.03.011"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35954"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Reimann F, Gribble FM (2002) Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes 51: 2757-2763.","DOI":"10.2337\/diabetes.51.9.2757"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Gribble FM, <i>et al.<\/i> (2003) A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes 52: 1147-1154.","DOI":"10.2337\/diabetes.52.5.1147"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Adachi A, <i>et al.<\/i> (1984) Convergence of hepatoportal glucose-sensitive afferent signals to glucose-sensitive units within the nucleus of the solitary tract. Neurosci Lett 46: 215-218.","DOI":"10.1016\/0304-3940(84)90444-0"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Niijima A (1984) Reflex control of the autonomic nervous system activity from the glucose sensors in the liver in normal and midpontine-transected animals. J Auton Nerv Syst 10: 279-285.","DOI":"10.1016\/0165-1838(84)90025-0"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Burcelin R, Dolci W, Thorens B (2000) Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice. Diabetes 49: 1643-1648.","DOI":"10.2337\/diabetes.49.10.1643"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Hevener AL, Bergman RN, Donovan CM (1997) Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes 46: 1521-1525.","DOI":"10.2337\/diab.46.9.1521"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Burcelin R, <i>et al.<\/i> (2001) Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes 50: 1720-1728.","DOI":"10.2337\/diabetes.50.8.1720"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Nakabayashi H, <i>et al.<\/i> (1996) Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol 271 (5 Pt 1): E808-813.","DOI":"10.1152\/ajpendo.1996.271.5.E808"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Ionut V, <i>et al.<\/i> (2005) Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones. Diabetologia 48: 967-975.","DOI":"10.1007\/s00125-005-1709-3"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Donovan CM, Halter JB, Bergman RN (1991) Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia. Diabetes 40: 155-158.","DOI":"10.2337\/diab.40.1.155"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Fujita S, Donovan CM (2005) Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to insulin-induced hypoglycemia. Diabetes 54: 3258-3264.","DOI":"10.2337\/diabetes.54.11.3258"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Ishigaki Y, <i>et al.<\/i> (2005) Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes 54: 322-332.","DOI":"10.2337\/diabetes.54.2.322"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Matsusue K, <i>et al.<\/i> (2005) Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111: 737-747.","DOI":"10.1172\/JCI200317223"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011927113563"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Chao L, <i>et al.<\/i> (2000) Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 106: 1221-1228.","DOI":"10.1172\/JCI11245"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1126\/science.1126010"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1038\/nn1456"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/54\/4\/54_4_497\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T06:56:39Z","timestamp":1618296999000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/54\/4\/54_4_497\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.kr-106","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}