{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:52:19Z","timestamp":1773424339118,"version":"3.50.1"},"reference-count":88,"publisher":"Japan Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocr J"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1507\/endocrj.kr-80","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T05:49:33Z","timestamp":1184824173000},"page":"359-370","source":"Crossref","is-referenced-by-count":27,"title":["Aldosterone as a Cardiovascular Risk Hormone"],"prefix":"10.1507","volume":"54","author":[{"given":"Takanobu","family":"YOSHIMOTO","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"HIRATA","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Tait SA, Tait JF (1998) The correspondence of S.A.S. Simpson and J.F. Tait with T. Reichstein during their collaborative work on the isolation and elucidation of the structure of electrocortin (later aldosterone). Steroids 63: 440-453.","DOI":"10.1016\/S0039-128X(98)00050-6"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Fuller PJ, Young MJ (2005) Mechanisms of mineralocorticoid action. Hypertension 46: 1227-1235.","DOI":"10.1161\/01.HYP.0000193502.77417.17"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Pascual-Le Tallec L, Lombes M (2005) The mineralocorticoid receptor: a journey exploring its diversity and specificity of action. Mol Endocrinol 19: 2211-2221.","DOI":"10.1210\/me.2005-0089"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(99)00087-2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Daugherty A, Cassis L (2004) Angiotensin II-mediated development of vascular diseases. Trends Cardiovasc Med 14: 117-120.","DOI":"10.1016\/j.tcm.2004.01.002"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.HYP.33.2.613","volume":"33","author":"HORIUCHI M","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Touyz RM (2005) Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology. Antioxid Redox Signal 7: 1302-1314.","DOI":"10.1089\/ars.2005.7.1302"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.15.8890"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.36843"},{"issue":"1, Pt.2","key":"10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/01.HYP.33.1.201","volume":"33","author":"EGUCHI S","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1583"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.165"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341: 709-717.","DOI":"10.1056\/NEJM199909023411001"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Funder JW (2004) Aldosterone, mineralocorticoid receptors and vascular inflammation. Mol Cell Endocrinol 217: 263-269.","DOI":"10.1016\/j.mce.2003.10.054"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.047"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1863"},{"issue":"5","key":"18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1440-1681.1993.tb01687.x","volume":"20","year":"1993","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1870","issn-type":"print"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lim PO, Rodgers P, Cardale K, Watson AD, MacDonald TM (1990) Potentially high prevalence of primary aldosteronism in a primary-care population. Lancet 353: 40.","DOI":"10.1016\/S0140-6736(05)74868-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Nishikawa T, Omura M (2000) Clinical characteristics of primary aldosteronism: its prevalence and comparative studies on various causes of primary aldosteronism in Yokohama Rosai Hospital. Biomed Pharmacother 54 (Suppl 1): 83s-85s.","DOI":"10.1016\/S0753-3322(00)80019-0"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Denolle T, Chatellier G, Julien J, Battaglia C, Luo P, Plouin PF (1993) Left ventricular mass and geometry before and after etiologic treatment in renovascular hypertension, aldosterone-producing adenoma, and pheochromocytoma. Am J Hypertens 6: 907-913.","DOI":"10.1093\/ajh\/6.11.907"},{"key":"22","unstructured":"22. Halimi JM, Mimran A (1995) Albuminuria in untreated patients with primary aldosteronism or essential hypertension. J Hypertens 13: 1801-1802."},{"issue":"5","key":"23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.27.5.1039","volume":"27","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Takeda R, Matsubara T, Miyamori I, Hatakeyama H, Morise T (1995) Vascular complications in patients with aldosterone producing adenoma in Japan: comparative study with essential hypertension. The Research Committee of Disorders of Adrenal Hormones in Japan. J Endocrinol Invest 18: 370-373.","DOI":"10.1007\/BF03347840"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90240-D"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L (1990) Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation 82: 1730-1736.","DOI":"10.1161\/01.CIR.82.5.1730"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000124251.06056.8e"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033263"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000091405.00772.6E"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Weber KT (2003) Aldosteronism revisited: perspectives on less well-recognized actions of aldosterone. J Lab Clin Med 142: 71-82.","DOI":"10.1016\/S0022-2143(03)00062-3"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Brilla CG, Pick R, Tan LB, Janicki JS, Weber KT (1990) Remodeling of the rat right and left ventricles in experimental hypertension. Circ Res 67: 1355-1364.","DOI":"10.1161\/01.RES.67.6.1355"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Brilla CG, Weber KT, Brilla CG, Pick R, Tan LB, Janicki JS, Weber KT (1992) Reactive and reparative myocardial fibrosis in arterial hypertension in the rat: Remodeling of the rat right and left ventricles in experimental hypertension. Cardiovasc Res 26: 671-677.","DOI":"10.1093\/cvr\/26.7.671"},{"key":"33","unstructured":"33. Brown L, Duce B, Miric G, Sernia C (1999) Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. J Am Soc Nephrol 10 (Suppl 11): S143-S148."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Young M, Head G, Funder J (1995) Determinants of cardiac fibrosis in experimental hypermineralocorticoid states. Am J Physiol 269: E657-E662.","DOI":"10.1152\/ajpendo.1995.269.4.E657"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Rocha R, Funder JW (2002) The pathophysiology of aldosterone in the cardiovascular system. Ann NY Acad Sci 970: 89-100.","DOI":"10.1111\/j.1749-6632.2002.tb04415.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Rocha R, Rudolph AE, Frierdich GE, Nachowiak DA, Kekec BK, Blomme EA, McMahon EG, Delyani JA, Rocha R, Stier CT Jr, Kifor I, Ochoa-Maya MR, Rennke HG, Williams GH, Adler GK (2002) Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol 283: H1802-H1810.","DOI":"10.1152\/ajpheart.01096.2001"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Rocha R, Stier CT Jr (2001) Pathophysiological effects of aldosterone in cardiovascular tissues. Trends Endocrinol Metab 12: 308-314.","DOI":"10.1016\/S1043-2760(01)00432-5"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.10.3871"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015854.60710.10"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Keidar S, Hayek T, Kaplan M, Pavlotzky E, Hamoud S, Coleman R, Aviram M (2003) Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol 41: 955-963.","DOI":"10.1097\/00005344-200306000-00019"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Takai S, Jin D, Muramatsu M, Kirimura K, Sakonjo H, Miyazaki M (2005) Eplerenone inhibits atherosclerosis in nonhuman primates. Hypertension 46: 1135-1139.","DOI":"10.1161\/01.HYP.0000184640.81730.22"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Delyani JA, Robinson EL, Rudolph AE (2001) Effect of a selective aldosterone receptor antagonist in myocardial infarction. Am J Physiol Heart Circ Physiol 281: H647-H654.","DOI":"10.1152\/ajpheart.2001.281.2.H647"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039104.56479.42"},{"issue":"4812","key":"44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","volume":"237","year":"1987","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.63.1.451"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1210\/me.7.4.597"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1210\/me.12.6.855"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2973"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1200"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.11.3698-3706.2002"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.1.135"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(95)00021-Q"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Gomez-Sanchez EP, Venkataraman MT, Thwaites D, Fort C (1990) ICV infusion of corticosterone antagonizes ICV-aldosterone hypertension. Am J Physiol 258: E649-E653.","DOI":"10.1152\/ajpendo.1990.258.4.E649"},{"key":"54","unstructured":"54. Young MJ, Funder JW (1996) The renin-angiotensin-aldosterone system in experimental mineralocorticoid-salt-induced cardiac fibrosis. Am J Physiol 271: E883-E888."},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.10.4145"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000080521.15238.E5"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.2797"},{"issue":"2","key":"58","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.HYP.25.2.170","volume":"25","year":"1995","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.4883"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.7.2519"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.8.3936"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Mizuno Y, Yoshimura M, Yasue H, Sakamoto T, Ogawa H, Kugiyama K, Harada E, Nakayama M, Nakamura S, Ito T, Shimasaki Y, Saito Y, Nakao K (2001) Aldosterone production is activated in failing ventricle in humans. Circulation 103: 72-77.","DOI":"10.1161\/01.CIR.103.1.72"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Gomez-Sanchez EP, Ahmad N, Romero DG, Gomez-Sanchez CE (2004) Origin of aldosterone in the rat heart. Endocrinology 145: 4796-4802.","DOI":"10.1210\/en.2004-0295"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Ahmad N, Romero DG, Gomez-Sanchez EP, Gomez-Sanchez CE (2004) Do human vascular endothelial cells produce aldosterone? Endocrinology 145: 3626-3629.","DOI":"10.1210\/en.2004-0081"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Liu H, Colavitti R, Rovira II, Finkel T (2005) Redox-dependent transcriptional regulation. Circ Res 97: 967-974.","DOI":"10.1161\/01.RES.0000188210.72062.10"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Makino Y, Okamoto K, Yoshikawa N, Aoshima M, Hirota K, Yodoi J, Umesono K, Makino I, Tanaka H (1996) Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system. J Clin Invest 98: 2469-2477.","DOI":"10.1172\/JCI119065"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109530200"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060698"},{"issue":"5561","key":"69","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1126\/science.1069300","volume":"295","author":"ZHANG Q","year":"2002","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Young MJ, Moussa L, Dilley R, Funder JW (2003) Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation. Endocrinology 144: 1121-1125.","DOI":"10.1210\/en.2002-220926"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.056"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000034738.79310.06"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Beswick RA, Dorrance AM, Leite R, Webb RC (2001) NADH\/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat. Hypertension 38: 1107-1011.","DOI":"10.1161\/hy1101.093423"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Iglarz M, Touyz RM, Viel EC, Amiri F, Schiffrin EL (2004) Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system. Am J Hypertens 17: 597-603.","DOI":"10.1016\/S0895-7061(04)00811-8"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Iglarz M, Touyz RM, Viel EC, Paradis P, Amiri F, Diep QN, Schiffrin EL (2003) Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension 42: 737-743.","DOI":"10.1161\/01.HYP.0000083511.91817.B1"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000118519.66430.22"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Somers MJ, Mavromatis K, Galis ZS, Harrison DG (2000) Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation 101: 1722-1728.","DOI":"10.1161\/01.CIR.101.14.1722"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT (2002) Aldosterone-induced inflammation in the rat heart : role of oxidative stress. Am J Pathol 161: 1773-1781.","DOI":"10.1016\/S0002-9440(10)64454-9"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Beswick RA, Zhang H, Marable D, Catravas JD, Hill WD, Webb RC (2001) Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response. Hypertension 37: 781-786.","DOI":"10.1161\/01.HYP.37.2.781"},{"issue":"4","key":"80","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/01.HYP.33.4.981","volume":"33","author":"ROBERT V","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000140771.21243.ed"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131860.80444.AB"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Min LJ, Mogi M, Li JM, Iwanami J, Iwai M, Horiuchi M (2005) Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells. Circ Res 97: 434-442.","DOI":"10.1161\/01.RES.0000180753.63183.95"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Harada E, Yoshimura M, Yasue H, Nakagawa O, Nakagawa M, Harada M, Mizuno Y, Nakayama M, Shimasaki Y, Ito T, Nakamura S, Kuwahara K, Saito Y, Nakao K, Ogawa H (2001) Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes. Circulation 104: 137-139.","DOI":"10.1161\/01.CIR.104.2.137"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1674"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Dzau VJ (1993) Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart. Basic Res Cardiol 88 (Suppl 1): 1-14.","DOI":"10.1007\/978-3-642-72497-8_1"},{"key":"87","unstructured":"87. Miyazaki M, Okamura T, Toda N (1988) Role of vascular angiotensin converting enzyme in hypertension. J Hypertens (Suppl 6): S13-15."},{"issue":"9","key":"88","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1440-1681.1991.tb01639.x","volume":"18","year":"1991","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1870","issn-type":"print"}],"container-title":["Endocrine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/54\/3\/54_3_359\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T12:27:06Z","timestamp":1683980826000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/endocrj\/54\/3\/54_3_359\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj.kr-80","relation":{},"ISSN":["0918-8959","1348-4540"],"issn-type":[{"value":"0918-8959","type":"print"},{"value":"1348-4540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}