{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:48:53Z","timestamp":1780757333115,"version":"3.54.1"},"reference-count":18,"publisher":"Japan Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocrinol Japon"],"published-print":{"date-parts":[[1991]]},"DOI":"10.1507\/endocrj1954.38.369","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T01:56:53Z","timestamp":1315879013000},"page":"369-376","source":"Crossref","is-referenced-by-count":28,"title":["A Dose Finding Study of a Super Long-Acting Luteinizing Hormone-Releasing Hormone Analog (Leuprolide Acetate Depot, TAP-144-SR) in the Treatment of Central Precocious Puberty"],"prefix":"10.1507","volume":"38","author":[{"given":"TOSHIAKI","family":"TANAKA","sequence":"first","affiliation":[{"name":"Division of Endocrinology Metabolism, National Children's Hospital, and Endocrine Research Laboratory, National Children's Medical Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ITSURO","family":"HIBI","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Metabolism, National Children's Hospital, and Endocrine Research Laboratory, National Children's Medical Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KIYOHIKO","family":"KATO","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yamanashi Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIRO","family":"SAITO","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Tokushima University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAOTAKA","family":"SHIMIZU","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Teikyo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEIZO","family":"SUWA","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Metabolism, Kanagawa Children's Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIRONORI","family":"NAKAJIMA","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"386","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Crowley WF, Comite F, Vale W, Rivier J, Loriaux DL, Culter GB (1981) Therapeutic use of pituitary desensitization with a long acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrinol Metab 52: 370-372.","DOI":"10.1210\/jcem-52-2-370"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Comite F, Pescovitz OH, Rieth KG, Dwyer AJ, Hench K, McNemar A, Loriaux DL, Culter GB (1984) Luteinizing hormone-releasing hormone analog treatment of boys with hypothalamic hamartoma and true precocious puberty. J Clin Endocrinol Metab 59: 888-892.","DOI":"10.1210\/jcem-59-5-888"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Styne DS, Harris DA, Egli CA, Conte FA, Kaplan SL, Rivier J, Vale W, Grumbach MM (1985) Treatment of true precocious puberty with a potent luteinizing hormone-releasing factor agonist: effect on growth, sexual maturation, pelvic sonography, and the hypothalamic-pituitarygonadal axis. J Clin Endocrinol Metab 61: 142-151.","DOI":"10.1210\/jcem-61-1-142"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Prescovitz OH, Comite F, Hench K, Barnes K, McNemar A, Foster C, Kenigsberg D, Loriaux DL, Cutler GB (1986) The N I H experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. Pediatr 108: 47-54.","DOI":"10.1016\/S0022-3476(86)80767-3"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Harris DA, Van Vliet G, Egli CA, Grumbach MM, Kaplan SL, Syne DM, Vainsel M (1985) Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. J Clin Endocirnol Metab 61: 152-159.","DOI":"10.1210\/jcem-61-1-152"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Lee PA, Page JD, The Leuprolide Study Group (1989) Effects of leuprolide in the treatment of central precocious puberty.J Pediatr 114: 321-324.","DOI":"10.1016\/S0022-3476(89)80806-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Luder AS, Holland FJ, Costigan DC, Jenner MR, Wielgosz G, Fazekas ATA (1984) Intranasal and subcutaneous treatment of central precocious puberty in both sexes with a long-acting analog of luteinizing hormone-releasing hormone. J Clin Endocrinol Metab 58: 966-972.","DOI":"10.1210\/jcem-58-6-966"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Stanhope R, Pringle PJ, Brook CGD (1988) Growth, growth hormone and sex steroid secretion in girls with central precocious puberty treated with a gonadotropin releasing hormone (GnRH) analogue. Acta Paediatr Scand 77: 525-530.","DOI":"10.1111\/j.1651-2227.1988.tb10694.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Roger M, Chaussain JL, Berlier P, Bost M, Canlorbe P, Colle M, Francois R, Garandeau P, Lahlou N, Morel Y, Shally AV (1986) Long term treatment of male and female precocious puberty by periodic administration of a long-acting preparation of D-Trpf'-luteinizing hormone-releasing hormone microcapsules.J Clin Endocrinol Metab 62: 670-677.","DOI":"10.1210\/jcem-62-4-670"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lahlou N, Roger M, Chaussain J-L, Feinstein M-C, Sultan C, Toublanc JE, Schally AV, Sholler R (1987) Gonadotropin and ix -subunit secretion during long term pituitary suppression by D-Trp6-luteinizing hormone-releasing hormone microcapsules as treatment of precocious puberty. J Clin Endocrinol Metab 65: 946-953.","DOI":"10.1210\/jcem-65-5-946"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kappy M, Stuart T, Perelman A, Clemons R (1989) Suppression of gonadotropin secretion by a longacting gonadotropin-releasing hormone analog (leuprolide acetate, Lupron Depot) in children with precocious puberty. J Clin Endocrinol Metab 69: 1087-1089.","DOI":"10.1210\/jcem-69-5-1087"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Wennink JMB, Waal HAD, Kessel H, Mulder GH, Foster JP, Schoemaker J (1988). Luteinizing hormone secretion patterns in boys at the onset of puberty measured using a highly sensitive immunoradiometric assay. J Clin Endocrinol Metab 67: 924-928.","DOI":"10.1210\/jcem-67-5-924"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Boyer RM, Finkelstein JW, Roffwarg HP, Kapen S, Weitzmen ED, Hellman L (1972) Synchronization of augmentated luteinizing hormone secretion with sleep during puberty. N Engl J Med 287: 582-586.","DOI":"10.1056\/NEJM197209212871203"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Jakacki RI, Ketch RP, Sauder SE, LLoyd JS, Hopwood NJ, Marchall JC (1982) Pulsatile secretion of luteinizing hormone in children. J Clin Endocrinol Metab 55: 453-457.","DOI":"10.1210\/jcem-55-3-453"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Dickerman Z, Prager-Lewin R, Laron Z (1976) Response of plasma LH and FSH to synthetic LH-RH in children at various pubertal stages. Am J Dis Child 130: 634-638.","DOI":"10.1001\/archpedi.1976.02120070060011"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Girard J, Baumann JB, Buhler U, Zuppinger K, Haas HG, Staub JJ, Wyss HI (1978) Cyproterone acetate and ACTH adrenal function. J Clin Endocrinol Metab 47: 581-6.","DOI":"10.1210\/jcem-47-3-581"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Savage DCL, Swift PGF (1981) Effect of cyproterone acetate on adrenal function in children with precocious puberty. Arch Dis Child 56: 218-222.","DOI":"10.1136\/adc.56.3.218"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sorgo WK, Kiraly E, Homoki J, Heinze E, Teller WM, Bierich JR, Moeller H, Ranke MB, Butenandt O, Knorr D (1987) The effects of cyproterone acetate on statural growth in children with precocious puberty. Acta Endocrinol (Copenh) 115: 44-49.","DOI":"10.1530\/acta.0.1150044"}],"container-title":["Endocrinologia Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj1954\/38\/4\/38_4_369\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:21:25Z","timestamp":1775881285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/endocrj1954\/38\/4\/38_4_369\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991]]}},"URL":"https:\/\/doi.org\/10.1507\/endocrj1954.38.369","relation":{},"ISSN":["0013-7219","2185-6370"],"issn-type":[{"value":"0013-7219","type":"print"},{"value":"2185-6370","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991]]},"article-number":"369"}}