{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:16:55Z","timestamp":1770322615730,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"Abstract<\/jats:title>\n \n Rationale<\/jats:title>\n Occasional cases of bronchiolitis show pathologic features somewhat suggestive of constrictive bronchiolitis, but with granulation tissue plugs that variably occlude the lumen in a pattern more typical of organizing pneumonia. These cases are poorly defined in the literature and the course of patients with this pattern of disease is unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To describe an uncommon and potentially treatable pattern of acute bronchiolitis that has been termed fibrosing bronchiolitis.<\/jats:p>\n Main Results: We report three patients with respiratory failure and acute onset of probable infectious or inhalational bronchiolitis that was characterized by centrilobular nodules and a variable tree-in-bud appearance on computed tomography. All patients showed an uncommon pattern of bronchiolitis on surgical lung biopsy. The pathologic abnormalities were confined to the bronchioles and consisted of reepithelialized, partially collagenized and variably polypoid plugs of granulation tissue that narrowed the bronchiolar lumens. All three patients improved dramatically on immunosuppressive therapy.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These cases of fibrosing bronchiolitis represent an uncommon pattern of acute bronchiolitis that is reversible if detected at an early stage. Early recognition and treatment may prevent development of permanent bronchiolar fibrosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1513\/annalsats.201504-234bc","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T15:37:25Z","timestamp":1436369845000},"page":"1323-1327","source":"Crossref","is-referenced-by-count":14,"title":["Fibrosing Bronchiolitis Evolving from Infectious or Inhalational Acute Bronchiolitis. A Reversible Lesion"],"prefix":"10.1093","volume":"12","author":[{"given":"Christopher J.","family":"Ryerson","sequence":"first","affiliation":[{"name":"Department of Medicine"},{"name":"Centre for Heart Lung Innovation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharla-Rae","family":"Olsen","sequence":"additional","affiliation":[{"name":"Prince George Regional Hospital, Prince George, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Carlsten","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Donagh","sequence":"additional","affiliation":[{"name":"Department of Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Bilawich","sequence":"additional","affiliation":[{"name":"Department of Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen K.","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Calgary, Calgary, Alberta, Canada; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Churg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"2026012303382597300_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1055\/s-2004-815603","article-title":"Bronchiolar complications of connective tissue diseases","volume":"24","author":"White","year":"2003","journal-title":"Semin Respir Crit Care Med"},{"key":"2026012303382597300_bib2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3346\/jkms.2013.28.6.915","article-title":"Toxic inhalational injury\u2013associated interstitial lung disease in children","volume":"28","author":"Lee","year":"2013","journal-title":"J Korean Med Sci"},{"key":"2026012303382597300_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2559.2008.03175.x","article-title":"The pathologist\u2019s approach to small airways disease","volume":"54","author":"Rice","year":"2009","journal-title":"Histopathology"},{"key":"2026012303382597300_bib4","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1056\/NEJMra1204664","article-title":"Obliterative bronchiolitis","volume":"370","author":"Barker","year":"2014","journal-title":"N Engl J Med"},{"key":"2026012303382597300_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012303382597300_bib6","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/rccm.200301-053SO","article-title":"Bronchiolar disorders","volume":"168","author":"Ryu","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012303382597300_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2214\/ajr.162.3.8109498","article-title":"Centrilobular opacities in the lung on high-resolution CT: diagnostic considerations and pathologic correlation","volume":"162","author":"Gruden","year":"1994","journal-title":"AJR Am J Roentgenol"},{"key":"2026012303382597300_bib8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00005382-198610000-00008","article-title":"Is bronchiolitis in infancy an antecedent of chronic lung disease in adolescence and adulthood?","volume":"1","author":"Pagtakhan","year":"1986","journal-title":"J Thorac Imaging"},{"key":"2026012303382597300_bib9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0272-5231(21)00925-4","article-title":"Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis","volume":"14","author":"Myers","year":"1993","journal-title":"Clin Chest Med"}],"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/12\/9\/1323\/66445864\/annalsats_12_9_1323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/12\/9\/1323\/66445864\/annalsats_12_9_1323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:38:33Z","timestamp":1769157513000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/12\/9\/1323\/8429238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,1]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,1]]}},"URL":"https:\/\/doi.org\/10.1513\/annalsats.201504-234bc","relation":{},"ISSN":["2329-6933","2325-6621"],"issn-type":[{"value":"2329-6933","type":"print"},{"value":"2325-6621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,9]]},"published":{"date-parts":[[2015,9,1]]}}}