{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:18:15Z","timestamp":1789906695698,"version":"4.0.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Mycobacterium abscessus group lung infection is characterized by low cure rates. Improvement in quality of life may be a reasonable treatment goal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate change in quality of life in response to therapy, predictors of improvement in quality of life, and association of quality of life with traditional outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-seven patients were treated for Mycobacterium abscessus group lung infection (including one with Mycobacterium chelonae) and were followed prospectively for 2 years between December 2009 and May 2012. St. George\u2019s Respiratory Questionnaire (SGRQ) was administered, chest computed tomography (CT) imaging was carried out, and culture data were collected at multiple time points. Predictors of improvement in the SGRQ total score greater than or equal to a minimal clinically important difference (MCID) at 12 months were evaluated.<\/jats:p>\n                    <jats:p>Measurements and Main Results: Patients were 85% female and 94% white, with a mean age of 65 years. Nine (20%) had a genetic diagnosis of cystic fibrosis (none F508del homozygous). Coinfection with Mycobacterium avium complex occurred in 28% and Pseudomonas in 26%. Chest CT imaging universally indicated bronchiectasis and nodules; 51% had lung cavities. Treatment included a mean of 17 months of antibiotics, and lung resection in 34%. Seventeen patients with M. avium complex (36%) and one with Mycobacterium kansasii were treated for coinfection. The mean SGRQ total score (SD) at baseline was 35 (20). At all follow-up time points, the mean SGRQ total score (SD) was significantly lower (better) than at baseline: 27 (17) at 3 months, P\u2009&amp;lt;\u20090.01; 27 (19) at 6 months, P\u2009&amp;lt;\u20090.01; 27 (20) at 12 months, P\u2009&amp;lt;\u20090.01; and 30 (22) at 24 months, P\u2009=\u20090.02. At 12 and 24 months, respectively, 60% and 56% had improvement greater than or equal to the MCID in SGRQ total score. Improvement greater than or equal to the MCID at 12 months was positively associated with a history of respiratory exacerbation, isolate susceptible to imipenem-cilastatin, and lung resection surgery, and negatively associated with nodules &amp;gt;4 mm in diameter on chest CT imaging, but these associations were not statistically significant in multivariable analysis. At 24 months, 16 patients (48%) with complete data were culture negative for 1 year and had discontinued M. abscessus group treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quality of life was a sensitive indicator of treatment response and has the potential to be a useful parameter to guide treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201508-529oc","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T12:13:08Z","timestamp":1446725588000},"page":"40-48","source":"Crossref","is-referenced-by-count":48,"title":["Improvement in Quality of Life after Therapy for\n                    <i>Mycobacterium abscessus<\/i>\n                    Group Lung Infection. A Prospective Cohort Study"],"prefix":"10.1093","volume":"13","author":[{"given":"Christopher A.","family":"Czaja","sequence":"first","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"},{"name":"Department of Family Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrah R.","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Daley","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"},{"name":"Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Cott","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado"},{"name":"Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2026020502525914500_bib1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1164\/ajrccm\/147.5.1271","article-title":"Clinical features of pulmonary disease caused by rapidly growing mycobacteria. An analysis of 154 patients","volume":"147","author":"Griffith","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2026020502525914500_bib2","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1164\/rccm.200207-678OC","article-title":"Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis","volume":"167","author":"Olivier","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1164\/rccm.201111-2016OC","article-title":"Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries","volume":"185","author":"Adjemian","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib4","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3201\/eid1510.090196","article-title":"Nontuberculous mycobacteria-associated lung disease in hospitalized persons, United States, 1998-2005","volume":"15","author":"Billinger","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"2026020502525914500_bib5","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1086\/648443","article-title":"Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology","volume":"49","author":"Cassidy","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2026020502525914500_bib6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/thx.2006.070797","article-title":"Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003","volume":"62","author":"Marras","year":"2007","journal-title":"Thorax"},{"key":"2026020502525914500_bib7","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1164\/rccm.201002-0310OC","article-title":"Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems","volume":"182","author":"Prevots","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases","volume":"175","author":"Griffith","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib9","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1164\/rccm.200905-0704OC","article-title":"Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients","volume":"180","author":"Jeon","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cid\/ciq237","article-title":"Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease","volume":"52","author":"Jarand","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2026020502525914500_bib11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.rmed.2010.12.012","article-title":"Outcomes in patients with Mycobacterium abscessus pulmonary disease treated with long-term injectable drugs","volume":"105","author":"Lyu","year":"2011","journal-title":"Respir Med"},{"key":"2026020502525914500_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1378\/chest.128.2.739","article-title":"Quality-of-life determinants in patients with clinically stable bronchiectasis","volume":"128","author":"Mart\u00ednez-Garc\u00eda","year":"2005","journal-title":"Chest"},{"key":"2026020502525914500_bib13","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1164\/ajrccm.156.2.9607083","article-title":"Validation of the St. George\u2019s Respiratory Questionnaire in bronchiectasis","volume":"156","author":"Wilson","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.5588\/ijtld.12.0672","article-title":"High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease","volume":"17","author":"Maekawa","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"key":"2026020502525914500_bib15","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.rmed.2011.08.004","article-title":"Impaired health-related quality of life in pulmonary nontuberculous mycobacterial disease","volume":"105","author":"Mehta","year":"2011","journal-title":"Respir Med"},{"key":"2026020502525914500_bib16","author":"Czaja"},{"key":"2026020502525914500_bib17","author":"Czaja"},{"key":"2026020502525914500_bib18","author":"Czaja"},{"key":"2026020502525914500_bib19","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jpeds.2008.05.005","article-title":"Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report","volume":"153","author":"Farrell","year":"2008","journal-title":"J Pediatr"},{"key":"2026020502525914500_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/thx.2005.043539","article-title":"Cystic fibrosis: terminology and diagnostic algorithms","volume":"61","author":"De Boeck","year":"2006","journal-title":"Thorax"},{"key":"2026020502525914500_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1164\/rccm.201003-0395OC","article-title":"Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus","volume":"183","author":"Koh","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0954-6111(06)80166-6","article-title":"The St George\u2019s Respiratory Questionnaire","volume":"85","author":"Jones","year":"1991","journal-title":"Respir Med"},{"key":"2026020502525914500_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1081\/COPD-200050513","article-title":"St. George\u2019s Respiratory Questionnaire: MCID","volume":"2","author":"Jones","year":"2005","journal-title":"COPD"},{"key":"2026020502525914500_bib24","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.rmed.2005.12.002","article-title":"Inhaled steroids improve quality of life in patients with steady-state bronchiectasis","volume":"100","author":"Mart\u00ednez-Garc\u00eda","year":"2006","journal-title":"Respir Med"},{"key":"2026020502525914500_bib25","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/thoraxjnl-2014-205587","article-title":"Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial","volume":"69","author":"Bilton","year":"2014","journal-title":"Thorax"},{"key":"2026020502525914500_bib26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1164\/rccm.201312-2208OC","article-title":"Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection","volume":"189","author":"Haworth","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1164\/rccm.201005-0756OC","article-title":"A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis","volume":"183","author":"Murray","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502525914500_bib28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.2013.1937","article-title":"Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial","volume":"309","author":"Altenburg","year":"2013","journal-title":"JAMA"},{"key":"2026020502525914500_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/COPD-200050647","article-title":"Minimal clinically important difference--exacerbations of COPD","volume":"2","author":"Calverley","year":"2005","journal-title":"COPD"},{"key":"2026020502525914500_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/thoraxjnl-2014-205918","article-title":"Quality of Life Questionnaire-Bronchiectasis: final psychometric analyses and determination of minimal important difference scores","volume":"70","author":"Quittner","year":"2015","journal-title":"Thorax"},{"key":"2026020502525914500_bib31","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1378\/chest.08-1190","article-title":"Determination of the minimal clinically important difference scores for the Cystic Fibrosis Questionnaire-Revised respiratory symptom scale in two populations of patients with cystic fibrosis and chronic Pseudomonas aeruginosa airway infection","volume":"135","author":"Quittner","year":"2009","journal-title":"Chest"},{"key":"2026020502525914500_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1148\/radiol.12111374","article-title":"Serial CT findings of Mycobacterium massiliense pulmonary disease compared with Mycobacterium abscessus disease after treatment with antibiotic therapy","volume":"263","author":"Kim","year":"2012","journal-title":"Radiology"},{"key":"2026020502525914500_bib33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1128\/AAC.01275-08","article-title":"A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae","volume":"53","author":"Nash","year":"2009","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/13\/1\/40\/66767893\/annalsats_13_1_40.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/13\/1\/40\/66767893\/annalsats_13_1_40.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:53:06Z","timestamp":1770277986000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/13\/1\/40\/8446579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]},"published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1513\/annalsats.201508-529oc","relation":{},"ISSN":["2329-6933","2325-6621"],"issn-type":[{"value":"2329-6933","type":"print"},{"value":"2325-6621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,1]]},"published":{"date-parts":[[2016,1,1]]}}}