{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:20:24Z","timestamp":1788373224948,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Peripheral pulmonary lesions requiring a diagnosis continue to present challenges to clinicians. One significant barrier is the inability to reliably locate peripheral lesions by bronchoscopic approaches. Multiplanar computed tomographic (CT) scan reconstruction is available to most physicians and provides axial, coronal, and sagittal images that may be used to estimate target lesion location and guide bronchoscopists during procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was performed to evaluate a systematic method of CT\u2013anatomic correlation based on multiplanar reconstruction CT scanning with monoplanar fluoroscopy during bronchoscopy to locate peripheral pulmonary lesions and confirm lesion location, using radial probe endobronchial ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of peripheral bronchoscopy cases in which radial probe endobronchial ultrasound for peripheral lesions was performed at a tertiary care, university hospital. All cases involved a systematic approach of reviewing axial, coronal, and sagittal CT reconstructions, coupled with monoplanar fluoroscopy during procedures to assist with locating peripheral lesions.<\/jats:p>\n                    <jats:p>Measurements and Main Results: Using the method of CT\u2013anatomic correlation, 332 of 348 (95.4%) of all lesions were successfully localized and confirmed, using radial probe endobronchial ultrasound. Lesions 1\u20132 cm in size accounted for 45% of all lesions, and the ability to locate lesions was not significantly different based on lesion size. Mean time to lesion localization was 6.8 minutes. Larger lesions and lesions demonstrating an air bronchus sign on CT scan were located in less time. The overall diagnostic yield was 58.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A systematic approach applying CT\u2013anatomic correlation with multiplanar CT scan reconstruction and monoplanar fluoroscopy during procedures can result in an efficient, and successful process for locating peripheral pulmonary lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201601-069oc","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T18:02:24Z","timestamp":1467914544000},"page":"1586-1592","source":"Crossref","is-referenced-by-count":31,"title":["Localization of Peripheral Pulmonary Lesions Using a Method of Computed Tomography\u2013Anatomic Correlation and Radial Probe Endobronchial Ultrasound Confirmation"],"prefix":"10.1093","volume":"13","author":[{"given":"Alexander C.","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Loiselle","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Medical Education, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Baty","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Misselhorn","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care Services, Barnes-Jewish Hospital, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2026020402514818100_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N Engl J Med"},{"key":"2026020402514818100_bib2","author":"Rivera","year":"2013"},{"key":"2026020402514818100_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1378\/chest.11-1764","article-title":"Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule","volume":"142","author":"Wang Memoli","year":"2012","journal-title":"Chest"},{"key":"2026020402514818100_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1164\/rccm.200612-1866OC","article-title":"Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial","volume":"176","author":"Eberhardt","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020402514818100_bib5","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/resp.12095","article-title":"Diagnostic yield of combined bronchoscopy and endobronchial ultrasonography, under LungPoint guidance for small peripheral pulmonary lesions","volume":"18","author":"Tamiya","year":"2013","journal-title":"Respirology"},{"key":"2026020402514818100_bib6","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1378\/chest.117.4.1049","article-title":"Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules","volume":"117","author":"Baaklini","year":"2000","journal-title":"Chest"},{"key":"2026020402514818100_bib7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1378\/chest.11-2030","article-title":"The role of conventional bronchoscopy in the workup of suspicious CT scan screen-detected pulmonary nodules","volume":"142","author":"van \u2019t Westeinde","year":"2012","journal-title":"Chest"},{"key":"2026020402514818100_bib8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1378\/chest.126.3.959","article-title":"Endobronchial ultrasonography using a guide sheath increases the ability to diagnose peripheral pulmonary lesions endoscopically","volume":"126","author":"Kurimoto","year":"2004","journal-title":"Chest"},{"key":"2026020402514818100_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1378\/chest.07-0637","article-title":"Factors related to diagnostic yield of transbronchial biopsy using endobronchial ultrasonography with a guide sheath in small peripheral pulmonary lesions","volume":"132","author":"Yamada","year":"2007","journal-title":"Chest"},{"key":"2026020402514818100_bib10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1513\/AnnalsATS.201311-384OC","article-title":"Radial probe endobronchial ultrasound for peripheral pulmonary lesions: a 5-year institutional experience","volume":"11","author":"Chen","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"2026020402514818100_bib11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1055\/s-0034-1395499","article-title":"Radial probe endobronchial ultrasound and novel navigation biopsy techniques","volume":"35","author":"Chenna","year":"2014","journal-title":"Semin Respir Crit Care Med"},{"key":"2026020402514818100_bib12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1164\/rccm.201507-1332OC","article-title":"Diagnostic yield and complications of bronchoscopy for peripheral lung lesions: results of the AQuIRE Registry","volume":"193","author":"Ost","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020402514818100_bib13","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1183\/09031936.00166708","article-title":"Ultrasound-guided transbronchial biopsy of solitary pulmonary nodules less than 20 mm","volume":"34","author":"Eberhardt","year":"2009","journal-title":"Eur Respir J"},{"key":"2026020402514818100_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1440-1843.2012.02276.x","article-title":"Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions","volume":"18","author":"Tay","year":"2013","journal-title":"Respirology"},{"key":"2026020402514818100_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1378\/chest.08-0577","article-title":"Endobronchial ultrasonography\u2013guided transbronchial needle aspiration increases the diagnostic yield of peripheral pulmonary lesions: a randomized trial","volume":"136","author":"Chao","year":"2009","journal-title":"Chest"}],"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/13\/9\/1586\/66657875\/annalsats_13_9_1586.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/13\/9\/1586\/66657875\/annalsats_13_9_1586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:51:53Z","timestamp":1770191513000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/13\/9\/1586\/8447881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,1]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1513\/annalsats.201601-069oc","relation":{},"ISSN":["2329-6933","2325-6621"],"issn-type":[{"value":"2329-6933","type":"print"},{"value":"2325-6621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,9,1]]}}}