{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:14:33Z","timestamp":1774116873660,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and positron emission tomography (PET)\u2013computed tomography (CT) are valuable tools for lung cancer staging. Data from tertiary referral centers suggest that these modalities are superior to mediastinoscopy in mediastinal staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To validate EBUS-TBNA for lung cancer staging in a community center with operators with various levels of experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>At an 800-bed community hospital, we reviewed all cases where EBUS-TBNA and PET-CT were performed for mediastinal staging by one of seven private practice pulmonologists. Cases were reviewed with lymph node dissection by mediastinoscopy after negative EBUS-TBNA.<\/jats:p>\n                    <jats:p>Measurements and Main Results: Of the 333 cases that were reviewed, 44 underwent mediastinoscopy after negative EBUS-TBNA. Four patients were positive for malignancy at stations 4R and 7 lymph nodes. In none of these cases did EBUS-TBNA reveal lymphoid tissue confirming the sample location. PET-CT showed mediastinal lymph nodes with increased avidity in two of the false-negative cases. EBUS-TBNA plus PET-CT had a sensitivity, specificity, and negative predictive value of 98.86, 100, and 94.87%, respectively, compared with mediastinoscopy for detecting metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EBUS-TBNA is accurate in detecting mediastinal metastasis of lung cancer in the community setting. PET-CT without uptake in lymph nodes reduces the likelihood of malignancy but cannot rule out mediastinal involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201603-216bc","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T13:59:47Z","timestamp":1468418387000},"page":"1802-1807","source":"Crossref","is-referenced-by-count":1,"title":["Endobronchial Ultrasound\u2013Guided Transbronchial Needle Aspiration for Mediastinal Staging in a Community Medical Center"],"prefix":"10.1093","volume":"13","author":[{"given":"Whittney A.","family":"Warren","sequence":"first","affiliation":[{"name":"Walter Reed National Military Medical Center Department of Pulmonary Medicine, Bethesda, Maryland"},{"name":"Wright State University Boonshoft School of Medicine, Dayton, Ohio"},{"name":"Miami Valley Hospital, Dayton, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared T.","family":"Hagaman","sequence":"additional","affiliation":[{"name":"Wright State University Boonshoft School of Medicine, Dayton, Ohio"},{"name":"Miami Valley Hospital, Dayton, Ohio"},{"name":"Pulmonary and Critical Care Consultants of Dayton, Dayton, Ohio; 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