{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:17:10Z","timestamp":1781842630408,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Studies suggest that adults with bronchiectasis are at increased risk of cardiovascular comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to quantify the relative risk of incident cardiovascular events after a respiratory tract infection among adults with bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using UK electronic primary care records, we conducted a within-person comparison using the self-controlled case series method. We calculated the relative risk of first-time cardiovascular events (either first myocardial infarction or stroke) after a respiratory tract infection compared with the individual\u2019s baseline risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our cohort consisted of 895 adult men and women with non\u2013cystic fibrosis bronchiectasis with a first myocardial infarction or stroke and at least one respiratory tract infection. There was an increased rate of first-time cardiovascular events in the 91-day period after a respiratory tract infection (incidence rate ratio, 1.56; 95% confidence interval, 1.20\u20132.02). The rate of a first cardiovascular event was highest in the first 3 days after a respiratory tract infection (incidence rate ratio, 2.73; 95% confidence interval, 1.41\u20135.27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest that respiratory tract infections are strongly associated with a transient increased risk of first-time myocardial infarction or stroke among people with bronchiectasis. As respiratory tract infections are six times more common in people with bronchiectasis than the general population, the increased risk has a disproportionately greater impact in these individuals. These findings may have implications for including cardiovascular risk modifications in airway infection treatment pathways in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201706-488oc","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T13:00:31Z","timestamp":1513861231000},"page":"315-321","source":"Crossref","is-referenced-by-count":34,"title":["Cardiovascular Outcomes after a Respiratory Tract Infection among Adults with Non\u2013Cystic Fibrosis Bronchiectasis: A General Population\u2013based Study"],"prefix":"10.1093","volume":"15","author":[{"given":"Vidya","family":"Navaratnam","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom"},{"name":"Department of Respiratory Epidemiology, Occupational Medicine, and Public Health, National Heart and Lung Institute, Imperial College London, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian A.","family":"Root","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Douglas","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Smeeth","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Public Health, University of Nottingham, Nottingham, 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