{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:50:07Z","timestamp":1782881407481,"version":"3.54.5"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Although obesity has been associated with asthma, body mass index is suboptimal to fully characterize adiposity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We examined the relation between adiposity and asthma in a large sample of the U.S. population, using indices defined by dual-energy X-ray absorptiometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 8,886 children (aged 8\u201319 yr) and 12,795 adults (aged 20\u201369 yr) from the 2001 to 2006 National Health and Nutrition Examination Survey. In addition to body mass index, percent body fat, waist circumference, and waist-to-height ratio, dual-energy X-ray absorptiometry was used to calculate whole-body and local adiposity indices: fat mass index; total, trunk, and legs percent fat; and trunk-to-total fat mass ratio, legs-to-total fat mass ratio, and trunk-to-legs fat mass ratios. Logistic regression was used for the analysis of adiposity measures and asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among children, general adiposity was significantly associated with asthma, with no major differences by sex. Results were driven by nonatopic children, in whom trunk-predominant (central) adiposity (assessed by waist circumference, waist-to-height ratio, trunk-to-total fat mass ratio, and trunk-to-legs fat mass ratio) was also associated with asthma. There were no significant associations among atopic children. Among adults, all adiposity indices were associated with asthma, with central adiposity significant only among women. The results in adults were driven by atopy, especially in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adiposity measured by dual-energy X-ray absorptiometry provides similar information to that obtained by using anthropometric indices among children of both sexes and among adult men. However, dual-energy X-ray absorptiometry provides additional information in adult women, in whom dual-energy X-ray absorptiometry\u2013measured central adiposity is significantly associated with asthma, particularly atopic asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201709-723oc","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T17:22:41Z","timestamp":1510852961000},"page":"322-330","source":"Crossref","is-referenced-by-count":33,"title":["Adiposity and Asthma in a Nationwide Study of Children and Adults in the United States"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-9885","authenticated-orcid":false,"given":"Erick","family":"Forno","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Libman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika H.","family":"Muzumdar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Children\u2019s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"2026020502162104200_bib1","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1378\/chest.130.1_suppl.4S","article-title":"The global burden of asthma","volume":"130","author":"Braman","year":"2006","journal-title":"Chest"},{"key":"2026020502162104200_bib2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"2026020502162104200_bib3","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.jaci.2013.09.041","article-title":"Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children","volume":"133","author":"Forno","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"2026020502162104200_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2431-13-121","article-title":"Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies","volume":"13","author":"Egan","year":"2013","journal-title":"BMC Pediatr"},{"key":"2026020502162104200_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1183\/09031936.00012112","article-title":"General and abdominal obesity and incident asthma in adults: the HUNT study","volume":"41","author":"Brumpton","year":"2013","journal-title":"Eur Respir J"},{"key":"2026020502162104200_bib6","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.rmed.2013.03.019","article-title":"Obesity and asthma: a coincidence or a causal relationship? 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