{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:57:18Z","timestamp":1793692638666,"version":"4.5.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Although the effects of traffic-related air pollution on respiratory exacerbations have been well documented, its impact on lung function in childhood remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our aim was to investigate the associations of prenatal, early, and lifetime traffic-related air pollution exposure with lung function at 8\u20139 years studying possible effect modification by sex, sensitization at 8\u20139 years, and early lower respiratory tract infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted this study among 788 children from the PARIS (Pollution and Asthma Risk: an Infant Study) birth cohort. Lung function tests were performed during the medical examination at 8\u20139 years. Traffic-related air pollution exposure during each trimester of pregnancy was estimated using nitrogen oxides background measurements. Postnatal traffic-related air pollution exposure was assessed by a nitrogen oxides air dispersion model at both residential and daycare\/school addresses. Associations between lung function and traffic-related air pollution exposure were analyzed by multiple linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher prenatal nitrogen oxides levels, especially during the second trimester of pregnancy, were associated with a lower forced expiratory flow at 25\u201375% of the forced vital capacity, but there were no significant associations between prenatal nitrogen oxide levels and forced vital capacity, forced expiratory volume during 1 second, or the forced expiratory volume during 1 second\/forced vital capacity ratio overall. Postnatal traffic-related air pollution exposure was associated with lower lung function among children with early lower respiratory tract infections or sensitization at 8\u20139 years, but not in the full cohort. In children with early repeated lower respiratory tract infections, an interquartile increase in lifetime nitrogen oxides exposure was associated with both a lower forced expiratory volume during 1 second (\u221262.6 ml; 95% confidence interval\u2009=\u2009\u2212107.0 to \u221218.1) and forced vital capacity (\u221255.7 ml; 95% confidence interval\u2009=\u2009\u2212109.5 to \u22121.8), but was not associated with the forced expiratory volume during 1 second\/forced vital capacity ratio. There was an association between greater early postnatal nitrogen oxide exposure and a lower forced expiratory volume during 1 second\/forced vital capacity ratio among sensitized children (\u22120.65%; 95% confidence interval\u2009=\u2009\u22121.25 to \u22120.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study sheds new light, suggesting associations between postnatal traffic-related air pollution exposure and reduced lung function may be enhanced by early, repeated lower respiratory tract infections or allergic sensitization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201711-900oc","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T08:29:14Z","timestamp":1525163354000},"page":"599-607","source":"Crossref","is-referenced-by-count":41,"title":["Traffic-Related Air Pollution, Lung Function, and Host Vulnerability. New Insights from the PARIS Birth Cohort"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-1724","authenticated-orcid":false,"given":"Nicolas","family":"Bougas","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4064, Epid\u00e9miologie environnementale, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-2247","authenticated-orcid":false,"given":"Fanny","family":"Ranci\u00e8re","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, EA 4064, Epid\u00e9miologie environnementale, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Beydon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Physiologie-Explorations Fonctionnelles Respiratoires, AP-HP, H\u00f4pital Armand-Trousseau, Paris, 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