{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:26:45Z","timestamp":1792268805685,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive method used to diagnose suspected mediastinal lymph nodes or masses. However, the accuracy of the diagnosis in patients with suspected lymphoma is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the diagnostic yield of EBUS-TBNA in patients with suspected lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search including EMBASE, MEDLINE, Cochrane Library, and Google Scholar was performed by two reviewers. Included articles were evaluated using the QUADAS-2 tool and meta-analysis with a binary method model to compare the sensitivity, specificity, and summary receiver operating characteristic curve in patients with suspected lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen studies (425 participants) were pooled in the analysis. EBUS-TBNA reported an overall sensitivity of 66.2% (confidence interval [CI], 55\u201375.8%; I \u00a02\u2009=\u200976.2%) and specificity of 99.3% (CI, 98.2\u201399.7%; I \u00a02\u2009=\u200940%). For a new diagnosis of lymphoma, 13 studies including 243 participants reported sensitivity of 67.1% (CI, 54.2\u201377.9%; I \u00a02\u2009=\u200966.8%) and specificity of 99.6% (CI, 99.1\u201399.8%; I \u00a02\u2009=\u20090%). For recurrence of lymphoma, 11 studies including 166 participants reported sensitivity of 77.8% (CI, 68.1\u201385.2%; I \u00a02\u2009=\u200920.2%) and specificity of 99.5% (CI, 98.9\u201399.8%; I \u00a02\u2009=\u20090%). In the recurrence group, we found the use of rapid onsite examination, sample size, and flow cytometry increased the sensitivity of EBUS-TBNA, albeit a potential source of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EBUS-TBNA has fair sensitivity for identifying a new diagnosis of lymphoma and fair to good sensitivity for identifying recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registry<\/jats:title>\n                    <jats:p>PROSPERO CRD42018102773 https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=102773.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201902-175oc","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T16:08:36Z","timestamp":1562774916000},"page":"1432-1439","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":65,"title":["Diagnostic Accuracy of Endobronchial Ultrasound Transbronchial Needle Aspiration in Lymphoma. A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":false,"given":"Gonzalo","family":"Labarca","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad San Sebastian, Concepcion, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melibea","family":"Sierra-Ruiz","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez","family":"Kheir","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Environmental Medicine, Tulane University, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Folch","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Majid","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-747X","authenticated-orcid":false,"given":"Hiren J.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, University of Florida, Gainesville, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Jantz","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, University of Florida, Gainesville, Florida; 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