{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:56:12Z","timestamp":1790506572876,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Exposure to a variety of substances in the workplace can cause new-onset asthma or aggravate preexisting asthma, both of which are considered work-related asthma (WRA). Understanding trends in the nature and causes of WRA can assist in the diagnosis and management of adult patients with asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe trends over 31 years of WRA surveillance in Michigan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Michigan law requires reporting of all known or suspected cases of occupational disease. WRA was confirmed by review of a standardized telephone interview and patient medical records. Enforcement inspections at the workplaces of the WRA cases included air monitoring and evaluation for asthma and asthma symptoms among coworkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Michigan surveillance program identified 3,634 WRA cases from 1988 to 2018, including nine deaths. The cumulative incidence rate of WRA decreased from 3.5 to 2.0 cases per 100,000 workers. Cases most frequently worked in manufacturing (56%), health care (12%), and education (4%). The cumulative incidence rate of WRA decreased in each of those three industries, while increasing in retail trade and accommodations and food services. The most common exposures to known asthma inducers were to cleaning agents and isocyanates; the percentage exposed to cleaning agents increased from 5% to 20%, and the percentage exposed to isocyanates decreased from 20% to 7%. Fifty-one percent had not applied for workers\u2019 compensation benefits. Only 5% of the 571 workplaces where air sampling was performed were above the allowable exposure limit. Fifteen percent (1,622 of 10,493) of coworkers of the index cases reported onset of asthma since beginning to work at the facility or being bothered at work by daily or weekly chest tightness, shortness of breath, or wheezing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The industries and exposures where Michigan adults develop WRA have changed during the past 31 years. The identification of WRA cases, including WRA deaths, underscores the need for continued vigilance to monitor changes in where and how workers are exposed to asthma-causing agents, physician consideration of workplace exposures in new-onset or worsening adult asthma, and adoption of workplace standards that reduce exposure and require workplace medical monitoring to prevent and reduce the morbidity and mortality of WRA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.201905-401oc","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T16:41:02Z","timestamp":1572885662000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":36,"title":["The Burden of Work-related Asthma in Michigan, 1988\u20132018"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-9409","authenticated-orcid":false,"given":"Mary Jo","family":"Reilly","sequence":"first","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Michigan State University, East Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Michigan State University, East Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Rosenman","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Michigan State University, East Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,1]]},"reference":[{"key":"2026012203415007100_bib1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.rmed.2015.03.004","article-title":"Web based listing of agents associated with new onset work-related asthma","volume":"109","author":"Rosenman","year":"2015","journal-title":"Respir Med"},{"key":"2026012203415007100_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/ACI.0b013e328344586a","article-title":"New causes of occupational asthma","volume":"11","author":"Quirce","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2026012203415007100_bib3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra1301758","article-title":"Occupational asthma","volume":"370","author":"Tarlo","year":"2014","journal-title":"N Engl J Med"},{"key":"2026012203415007100_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1164\/rccm.167.5.787","article-title":"American Thoracic Society Statement: Occupational contribution to the burden of airway disease","volume":"167","author":"Balmes","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012203415007100_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1164\/rccm.812011ST","article-title":"An official American Thoracic Society statement: work-exacerbated asthma","volume":"184","author":"Henneberger","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012203415007100_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/02770900903509073","article-title":"Prevalence of work-related asthma in Michigan, Minnesota, and Oregon","volume":"47","author":"Lutzker","year":"2010","journal-title":"J Asthma"},{"key":"2026012203415007100_bib7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3109\/02770903.2014.939282","article-title":"Distribution of asthma by occupation: Washington State behavioral risk factor surveillance system data, 2006-2009","volume":"51","author":"Anderson","year":"2014","journal-title":"J Asthma"},{"key":"2026012203415007100_bib8","first-page":"1","article-title":"ATS Patient Education Series: work-exacerbated asthma","volume":"197","author":"American Thoracic Society","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012203415007100_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ajim.20538","article-title":"How many deaths will it take? A death from asthma associated with work-related environmental tobacco smoke","volume":"51","author":"Stanbury","year":"2008","journal-title":"Am J Ind Med"},{"key":"2026012203415007100_bib10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ajim.20183","article-title":"Asthma death after spraying polyurethane truck bedliner","volume":"48","author":"Chester","year":"2005","journal-title":"Am J Ind Med"},{"key":"2026012203415007100_bib11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/thx.2010.136762","article-title":"Costs of occupational asthma in the UK","volume":"66","author":"Ayres","year":"2011","journal-title":"Thorax"},{"key":"2026012203415007100_bib12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1136\/oem.2004.019489","article-title":"Incidence by occupation and industry of acute work related respiratory diseases in the UK, 1992-2001","volume":"62","author":"McDonald","year":"2005","journal-title":"Occup Environ Med"},{"key":"2026012203415007100_bib13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1513\/AnnalsATS.201810-701OC","article-title":"Adult asthma among workers in Ontario: results from the occupational disease surveillance system","volume":"16","author":"Logar-Henderson","year":"2019","journal-title":"Ann Am Thorac Soc"},{"key":"2026012203415007100_bib14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.jom.0000058347.05741.f9","article-title":"Cleaning products and work-related asthma","volume":"45","author":"Rosenman","year":"2003","journal-title":"J Occup Environ Med"},{"key":"2026012203415007100_bib15","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/02770903.2017.1299755","article-title":"Fragrances and work-related asthma-California surveillance data, 1993-2012","volume":"54","author":"Weinberg","year":"2017","journal-title":"J Asthma"},{"key":"2026012203415007100_bib16","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/ajim.22527","article-title":"Isocyanates and work-related asthma: findings from California, Massachusetts, Michigan, and New Jersey, 1993-2008","volume":"58","author":"Lefkowitz","year":"2015","journal-title":"Am J Ind Med"},{"key":"2026012203415007100_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/(SICI)1097-0274(199710)32:4<325::AID-AJIM1>3.0.CO;2-T","article-title":"Work-related asthma and respiratory symptoms among workers exposed to metal-working fluids","volume":"32","author":"Rosenman","year":"1997","journal-title":"Am J Ind Med"},{"key":"2026012203415007100_bib18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/JOM.0b013e31820fd0c3","article-title":"A study of characteristics of Michigan workers with work-related asthma exposed to welding","volume":"53","author":"Banga","year":"2011","journal-title":"J Occup Environ Med"},{"key":"2026012203415007100_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/02770903.2014.950428","article-title":"Swimming facilities and work-related asthma","volume":"52","author":"Rosenman","year":"2015","journal-title":"J Asthma"},{"key":"2026012203415007100_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ajim.20539","article-title":"Work-related asthma in the educational services industry: California, Massachusetts, Michigan, and New Jersey, 1993-2000","volume":"51","author":"Mazurek","year":"2008","journal-title":"Am J Ind Med"},{"key":"2026012203415007100_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ajim.20138","article-title":"Work-related asthma among health care workers: surveillance data from California, Massachusetts, Michigan, and New Jersey, 1993-1997","volume":"47","author":"Pechter","year":"2005","journal-title":"Am J Ind Med"},{"key":"2026012203415007100_bib22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3109\/02770903.2011.604881","article-title":"Work-related asthma in Washington State","volume":"48","author":"Anderson","year":"2011","journal-title":"J Asthma"},{"key":"2026012203415007100_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/01.jom.0000063620.37065.6f","article-title":"Work-related reactive airways dysfunction syndrome cases from surveillance in selected US states","volume":"45","author":"Henneberger","year":"2003","journal-title":"J Occup Environ Med"},{"key":"2026012203415007100_bib24","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/oem.2003.008177","article-title":"A descriptive study of work aggravated asthma","volume":"61","author":"Goe","year":"2004","journal-title":"Occup Environ Med"},{"key":"2026012203415007100_bib25","first-page":"1","article-title":"Surveillance of work-related asthma in selected U.S. states using surveillance guidelines for state health departments--California, Massachusetts, Michigan, and New Jersey, 1993-1995","volume":"48","author":"Jajosky","year":"1999","journal-title":"MMWR CDC Surveill Summ"},{"key":"2026012203415007100_bib26","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1378\/chest.88.3.376","article-title":"Reactive airways dysfunction syndrome (RADS): persistent asthma syndrome after high level irritant exposures","volume":"88","author":"Brooks","year":"1985","journal-title":"Chest"},{"key":"2026012203415007100_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/ACI.0000000000000247","article-title":"Do chronic workplace irritant exposures cause asthma?","volume":"16","author":"Dumas","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2026012203415007100_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4168\/aair.2019.11.2.188","article-title":"Update on the management of occupational asthma and work-exacerbated asthma","volume":"11","author":"Lau","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"2026012203415007100_bib29","author":"Michigan Public Health Code Act 368 of 1978","year":"1978"},{"key":"2026012203415007100_bib30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/oemed-2018-105414","article-title":"Emerging trends in the UK incidence of occupational asthma: should we be worried?","volume":"76","author":"Seed","year":"2019","journal-title":"Occup Environ Med"},{"key":"2026012203415007100_bib31","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1378\/chest.06-2487","article-title":"Occupational asthma and work-exacerbated asthma: factors associated with time to diagnostic steps","volume":"131","author":"Santos","year":"2007","journal-title":"Chest"},{"key":"2026012203415007100_bib32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF03403697","article-title":"Barriers to diagnosis of occupational asthma in Ontario","volume":"96","author":"Poonai","year":"2005","journal-title":"Can J Public Health"},{"key":"2026012203415007100_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/ACI.0b013e3283449063","article-title":"Occupational lower airway disease in relation to World Trade Center inhalation exposure","volume":"11","author":"de la Hoz","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2026012203415007100_bib34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.rmed.2015.01.003","article-title":"Understanding health beliefs and behaviour in workers with suspected occupational asthma","volume":"109","author":"Walters","year":"2015","journal-title":"Respir Med"},{"key":"2026012203415007100_bib35","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1513\/AnnalsATS.201305-119ST","article-title":"An official American Thoracic Society proceedings: work-related asthma and airway diseases. Presentations and discussion from the Fourth Jack Pepys Workshop on Asthma in the Workplace","volume":"10","author":"Tarlo","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"2026012203415007100_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/MCP.0000000000000352","article-title":"Occupational asthma: diagnostic challenges and management dilemmas","volume":"23","author":"Trivedi","year":"2017","journal-title":"Curr Opin Pulm Med"},{"key":"2026012203415007100_bib37","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3132\/pcrj.2007.00064","article-title":"Are we failing workers with symptoms suggestive of occupational asthma?","volume":"16","author":"Fishwick","year":"2007","journal-title":"Prim Care Respir J"},{"key":"2026012203415007100_bib38","article-title":"Michigan companies using isocyanates","author":"U.S. Environmental Protection Agency Toxics Release Inventory"},{"key":"2026012203415007100_bib39","author":"Michigan Department of Environment, Great Lakes, and Energy"},{"key":"2026012203415007100_bib40","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.annepidem.2017.03.002","article-title":"Opportunities and obstacles in translating evidence to policy in occupational asthma","volume":"28","author":"Tarlo","year":"2018","journal-title":"Ann Epidemiol"},{"key":"2026012203415007100_bib41","article-title":"California Department of Public Health, Occupational Health Branch, Work-Related Asthma Prevention Program. Healthy cleaning & asthma-safer schools: a how-to guide","author":"Shrem","year":"2014"},{"key":"2026012203415007100_bib42","article-title":"Sanitizers and disinfectants guide","author":"Healthy Schools Network, Inc.","year":"2014"},{"key":"2026012203415007100_bib43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ajic.2015.01.029","article-title":"Cleaning and disinfecting environmental surfaces in health care: toward an integrated framework for infection and occupational illness prevention","volume":"43","author":"Quinn","year":"2015","journal-title":"Am J Infect Control"},{"key":"2026012203415007100_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/oeh.1999.5.1.1","article-title":"An evaluation of the incidence of work-related asthma in the United States","volume":"5","author":"Henneberger","year":"1999","journal-title":"Int J Occup Environ Health"},{"key":"2026012203415007100_bib45","article-title":"Guidelines for the diagnosis and management of asthma (EPR-3)","author":"National Heart, Lung, and Blood Institute","year":"2007"},{"key":"2026012203415007100_bib46","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1378\/chest.08-0201","article-title":"Diagnosis and management of work-related asthma: American College Of Chest Physicians consensus statement","volume":"134","author":"Tarlo","year":"2008","journal-title":"Chest"},{"key":"2026012203415007100_bib47","first-page":"38","article-title":"Work-related asthma from exposure to isocyanate levels below the Michigan OSHA permissible exposure limit","volume-title":"Isocyanates: sampling, analysis and health effects.","author":"Reilly","year":"2002"},{"key":"2026012203415007100_bib48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/thx.2006.061952","article-title":"Outcome of occupational asthma after cessation of exposure: a systematic review","volume":"62","author":"Rachiotis","year":"2007","journal-title":"Thorax"},{"key":"2026012203415007100_bib49","author":"Rosenman"},{"key":"2026012203415007100_bib50","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/oem.59.1.58","article-title":"Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures","volume":"59","author":"Tarlo","year":"2002","journal-title":"Occup Environ Med"},{"key":"2026012203415007100_bib51","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S2213-2600(16)30424-6","article-title":"Occupational lung diseases: from old and novel exposures to effective preventive strategies","volume":"5","author":"Cullinan","year":"2017","journal-title":"Lancet Respir Med"}],"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/17\/3\/284\/66348333\/annalsats_17_3_284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/17\/3\/284\/66348333\/annalsats_17_3_284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:46:43Z","timestamp":1769071603000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/17\/3\/284\/8419198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,1]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1513\/annalsats.201905-401oc","relation":{},"ISSN":["2329-6933","2325-6621"],"issn-type":[{"value":"2329-6933","type":"print"},{"value":"2325-6621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2020,3,1]]},"assertion":[{"value":"2019-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}