{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:07:12Z","timestamp":1787022432292,"version":"build-2736575974"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Maternal obesity is associated with asthma in the offspring. Whether cord blood leptin is associated with risk of asthma in offspring is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess whether cord blood leptin from women with pregestational obesity predict preschool asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this birth cohort study, we divided pregnant women into three weight categories during the first obstetric visit: normal (NL), overweight (OW), and obese (OB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We followed the offspring recording atopy, wheezing, and other respiratory illnesses through 30 months of age. Cord blood and peripheral blood at 30 months of age were taken to measure cytokines, adipokines, metabolic biomarkers, and specific immunoglobulin E. Adjusted regression models were used to evaluate the association between maternal obesity and offspring asthma risk, defined by a positive Asthma Predictive Index. Three hundred thirty-nine mothers were recruited; 140 offspring were born from NL, 80 from OW, and 119 from OB mothers. OB women were older and less educated and had higher parity and higher C-section frequency. Offspring from OB women had higher birthweight, head circumference, and placental weight compared with other groups. The proportion of Asthma Predictive Index positive at 30 months of age was 12.2% in the NL, 14.7% in the OW, and 16.8% in the OB group (P\u2009=\u20090.18). Offspring from OB women had higher leptin, leptin\/adiponectin ratio, interleukin-10, and insulin than the OW group and higher leptin than the NL group. In the adjusted analysis, offspring from OB mothers with high cord blood leptin had increased risk of asthma (adjusted odds ratio, 1.30; 95% confidence interval, 1.1\u20131.55; P\u2009=\u20090.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Offspring from obese mothers with high cord blood leptin have 30% higher asthma risk at age 3.<\/jats:p>\n                    <jats:p>Clinical trial registered with ClinicalTrials.gov (NCT02903134).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.202001-080oc","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T17:25:34Z","timestamp":1596043534000},"page":"1583-1589","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":27,"title":["Leptin in Cord Blood Associates with Asthma Risk at Age 3 in the Offspring of Women with Gestational Obesity"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4281","authenticated-orcid":false,"given":"Jose A.","family":"Castro-Rodriguez","sequence":"first","affiliation":[{"name":"Division of Pediatrics, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-9885","authenticated-orcid":false,"given":"Erick","family":"Forno","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Casanello","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, School of Medicine"},{"name":"Department of Obstetrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oslando","family":"Padilla","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo J.","family":"Krause","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Uauy","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"2026012203452811400_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"2026012203452811400_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aller.2012.03.001","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC) phase three: a global synthesis","volume":"41","author":"Mallol","year":"2013","journal-title":"Allergol Immunopathol (Madr)"},{"key":"2026012203452811400_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4067\/S0034-98872007000500005","article-title":"[Changes in the prevalence of asthma in Chilean school age children between 1994 and 2002. 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