{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:15:57Z","timestamp":1789820157113,"version":"4.0.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Although platelets are considered key inflammatory mediators in respiratory diseases, their role in bronchiectasis has not been fully explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We hypothesized that thrombocytosis in stable state may be associated with bronchiectasis severity and worse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with bronchiectasis have been enrolled from 10 centers in Europe and Israel, with platelet count recorded during stable state. The primary outcome was 5-year all-cause mortality. Secondary outcomes included exacerbations, hospitalizations, and mortality at 1, 2, and 3-year follow-up. Analyses were conducted using logistic regression after adjustment for confounding variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 1,771 patients (median age, 67 yr; 63.4% female) included, 136 (7.7%) had thrombocytosis. Patients with thrombocytosis had a significantly higher disease severity, worse quality of life, higher number of exacerbations and hospitalizations, and higher mortality rate at both 3-year (23 [22.8%] vs. 83 [8.5%], respectively; P\u2009&amp;lt;\u20090.01) and 5-year (26 [35.1%] vs. 116 [15.9%], respectively; P\u2009&amp;lt;\u20090.01) in comparison with those with normal platelet count. Thrombocytosis was significantly associated with hospitalizations because of severe exacerbations (odds ratio [OR], 1.83; 95% confidence interval [CI], 1.20\u20132.79; P\u2009=\u20090.01) after 1-year follow-up, as well as increased 3-year (OR, 3.06; 95% CI, 1.74\u20135.39; P\u2009&amp;lt;\u20090.01) and 5-year (OR, 2.46; 95% CI, 1.39\u20134.37; P\u2009&amp;lt;\u20090.01) mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Platelets represent a cheap and easy-to-evaluate biomarker, and the presence of thrombocytosis during stable state is associated with disease severity, hospitalizations because of exacerbations, poor quality of life, and mortality in adults with bronchiectasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1513\/annalsats.202002-094oc","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T16:33:43Z","timestamp":1611851623000},"page":"1316-1325","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":13,"title":["Thrombocytosis during Stable State Predicts Mortality in Bronchiectasis"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-4531","authenticated-orcid":false,"given":"Stefano","family":"Aliberti","sequence":"first","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, UO Pneumologia, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Sotgiu","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari\u2013Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gramegna","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, UO Pneumologia, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Galway University Hospitals, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Polverino","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d\u2019Hebron, Barcelona Institut de Recerca Vall d\u2019Hebron, CIBER, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Torres","sequence":"additional","affiliation":[{"name":"Servei de Pneumologia, Hospital Clinic, Universidad de Barcelona, IDIBAPS CIBERES, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter C.","family":"Goeminne","sequence":"additional","affiliation":[{"name":"AZ Nikolaas, Sint-Niklaas, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Dimakou","sequence":"additional","affiliation":[{"name":"5th Respiratory Department, \u201cSotiria\u201d Chest Diseases Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Shteinberg","sequence":"additional","affiliation":[{"name":"Pulmonology Institute and CF Center, Carmel Medical Center and the B. 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and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Galway University Hospitals, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Dore","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari\u2013Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Saderi","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, University of Sassari\u2013Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Faverio","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Milan Bicocca, AO San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Amati","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, UO Pneumologia, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo G.","family":"Corsico","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation and Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, 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