{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:31:20Z","timestamp":1769131880417,"version":"3.49.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"DOI":"10.1513\/annalsats.202209-780cc","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T11:15:13Z","timestamp":1685618113000},"page":"911-916","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":0,"title":["Sodium-Glucose Cotransporter 2 Inhibitor\u2013induced Ketoacidosis and Non-Ketotic Acidosis: When Is There a Role for Bicarbonate?"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-9602","authenticated-orcid":false,"given":"Yvonne","family":"Fahy","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-9573","authenticated-orcid":false,"given":"John G.","family":"Laffey","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"},{"name":"School of Medicine, University of Galway, Galway, Ireland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9524-4021","authenticated-orcid":false,"given":"Bairbre","family":"McNicholas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Intensive Care and Pain Medicine, Galway University Hospitals, Saolta University Hospital Group, Galway, Ireland"},{"name":"School of Medicine, University of Galway, Galway, Ireland; and"},{"name":"Department of Nephrology, University Hospital Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2026012203272675900_bib1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1056\/NEJM198212233072603","article-title":"Plasma acid-base patterns in diabetic ketoacidosis","volume":"307","author":"Adrogu\u00e9","year":"1982","journal-title":"N Engl J Med"},{"key":"2026012203272675900_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2924","article-title":"Ketoacidosis associated with SGLT2 inhibitor treatment: analysis of FAERS data","volume":"33","author":"Blau","year":"2017","journal-title":"Diabetes Metab Res Rev"},{"key":"2026012203272675900_bib3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41569-020-0406-8","article-title":"SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control","volume":"17","author":"Cowie","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2026012203272675900_bib4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2337\/dc16-2724","article-title":"Renal handling of ketones in response to sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes","volume":"40","author":"Ferrannini","year":"2017","journal-title":"Diabetes Care"},{"key":"2026012203272675900_bib5","doi-asserted-by":"crossref","first-page":"805281","DOI":"10.3389\/fphar.2022.805281","article-title":"Fatty acid \u03b2-oxidation in kidney diseases: perspectives on pathophysiological mechanisms and therapeutic opportunities","volume":"13","author":"Gao","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026012203272675900_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrneph.2012.186","article-title":"Treatment of acute metabolic acidosis: a pathophysiologic approach","volume":"8","author":"Kraut","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"2026012203272675900_bib7","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2215\/CJN.17621120","article-title":"Euglycemic ketoacidosis as a complication of SGLT2 inhibitor therapy","volume":"16","author":"Palmer","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026012203272675900_bib8","doi-asserted-by":"crossref","first-page":"e2886","DOI":"10.1002\/dmrr.2886","article-title":"Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: basic mechanisms and therapeutic perspectives","volume":"33","author":"Qiu","year":"2017","journal-title":"Diabetes Metab Res Rev"},{"key":"2026012203272675900_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fendo.2017.00106","article-title":"Review of evidence for adult diabetic ketoacidosis management protocols","volume":"8","author":"Tran","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026012203272675900_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.semnephrol.2019.04.004","article-title":"Molecular pathophysiology of acid-base disorders","volume":"39","author":"Wagner","year":"2019","journal-title":"Semin Nephrol"},{"key":"2026012203272675900_bib11","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1152\/ajprenal.00554.2010","article-title":"Role of NH3 and NH4+ transporters in renal acid-base transport","volume":"300","author":"Weiner","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"2026012203272675900_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2014.01.040","article-title":"SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats","volume":"727","author":"Yokono","year":"2014","journal-title":"Eur J Pharmacol"}],"container-title":["Annals of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/20\/6\/911\/66271124\/annalsats_20_6_911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/20\/6\/911\/66271124\/annalsats_20_6_911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:28:21Z","timestamp":1769070501000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/20\/6\/911\/8415018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1513\/annalsats.202209-780cc","relation":{},"ISSN":["2329-6933","2325-6621"],"issn-type":[{"value":"2329-6933","type":"print"},{"value":"2325-6621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,6,1]]},"assertion":[{"value":"2022-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}