{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:09:17Z","timestamp":1770991757527,"version":"3.50.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Granulomatous lung diseases, such as sarcoidosis, hypersensitivity pneumonitis, Wegener's granulomatosis, and chronic beryllium disease, along with granulomatous diseases of known infectious etiologies, such as tuberculosis, are major causes of morbidity and mortality throughout the world. Clinical manifestations of these diseases are highly heterogeneous, and the determinants of disease susceptibility and clinical course (e.g., resolution vs. chronic, progressive fibrosis) are largely unknown. The underlying pathogenic mechanisms of these diseases also remain poorly understood. Within this context, these diseases have been approached using genomic and proteomic technologies to allow us to identify patterns of gene\/protein expression that track with clinical disease or to identify new pathways involved in disease pathogenesis. The results from these initial studies highlight the potential for these \u201c-omics\u201d approaches to reveal novel insights into the pathogenesis of granulomatous lung disease and provide new tools to improve diagnosis, clinical classification, course prediction, and response to therapy. Realizing this potential will require collaboration among multidisciplinary groups with expertise in the respective technologies, bioinformatics, and clinical medicine for these complex diseases.<\/jats:p>","DOI":"10.1513\/pats.200607-140jg","type":"journal-article","created":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T19:33:02Z","timestamp":1167852782000},"page":"101-107","source":"Crossref","is-referenced-by-count":7,"title":["Expression Profiling in Granulomatous Lung Disease"],"prefix":"10.1093","volume":"4","author":[{"given":"Edward S.","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Moller","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"2026020502003605300_BIB1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1586\/14789450.2.2.187","volume":"2","year":"2005","journal-title":"Expert Rev Proteomics"},{"key":"2026020502003605300_BIB2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/mas.20032","volume":"24","year":"2005","journal-title":"Mass Spectrom Rev"},{"key":"2026020502003605300_BIB3","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1152\/ajplung.00301.2003","volume":"287","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026020502003605300_BIB4","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1183\/09031936.98.12030716","volume":"12","year":"1998","journal-title":"Eur Respir J"},{"key":"2026020502003605300_BIB5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/thx.52.5.431","volume":"52","year":"1997","journal-title":"Thorax"},{"key":"2026020502003605300_BIB6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00109-003-0511-2","volume":"82","year":"2004","journal-title":"J Mol Med"},{"key":"2026020502003605300_BIB7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01902140490276267","volume":"30","year":"2004","journal-title":"Exp Lung Res"},{"key":"2026020502003605300_BIB8","first-page":"1","volume":"45","year":"1996","journal-title":"Hiroshima J Med Sci"},{"key":"2026020502003605300_BIB9","first-page":"5","volume":"19","year":"2002","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026020502003605300_BIB10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4414\/smw.2001.09808","volume":"131","year":"2001","journal-title":"Swiss Med Wkly"},{"key":"2026020502003605300_BIB11","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1183\/09031936.99.13613389","volume":"13","year":"1999","journal-title":"Eur Respir J"},{"key":"2026020502003605300_BIB12","first-page":"59","volume":"19","year":"2002","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026020502003605300_BIB13","first-page":"89","volume":"7","year":"2001","journal-title":"Mol Vis"},{"key":"2026020502003605300_BIB14","first-page":"135","volume":"77","year":"2004","journal-title":"Toxicol Sci"},{"key":"2026020502003605300_BIB15","first-page":"10","volume":"21","year":"2004","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026020502003605300_BIB16","first-page":"1","volume":"54","year":"2003","journal-title":"Acta Biol Hung"},{"key":"2026020502003605300_BIB17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1155\/2001\/607263","volume":"17","year":"2001","journal-title":"Dis Markers"},{"key":"2026020502003605300_BIB18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/elps.1150140141","volume":"14","year":"1993","journal-title":"Electrophoresis"},{"key":"2026020502003605300_BIB19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/00365519309092562","volume":"53","year":"1993","journal-title":"Scand J Clin Lab Invest"},{"key":"2026020502003605300_BIB20","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/pmic.200400908","volume":"4","year":"2004","journal-title":"Proteomics"},{"key":"2026020502003605300_BIB21","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1002\/1522-2683(20000701)21:13<2703::AID-ELPS2703>3.0.CO;2-W","volume":"21","year":"2000","journal-title":"Electrophoresis"},{"key":"2026020502003605300_BIB22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1183\/09031936.03.00060902","volume":"21","year":"2003","journal-title":"Eur Respir J"},{"key":"2026020502003605300_BIB23","first-page":"182","volume":"21","year":"2004","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"2026020502003605300_BIB24","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1002\/1522-2683(200210)23:19<3434::AID-ELPS3434>3.0.CO;2-R","volume":"23","year":"2002","journal-title":"Electrophoresis"},{"key":"2026020502003605300_BIB25","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/pmic.200301007","volume":"5","year":"2005","journal-title":"Proteomics"},{"key":"2026020502003605300_BIB26","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1164\/rccm.200507-1126OC","volume":"173","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502003605300_BIB27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1183\/09031936.96.09020307","volume":"9","year":"1996","journal-title":"Eur Respir J"},{"key":"2026020502003605300_BIB28","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1002\/pmic.200401206","volume":"5","year":"2005","journal-title":"Proteomics"},{"key":"2026020502003605300_BIB29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.20040429","volume":"201","year":"2005","journal-title":"J Exp Med"},{"key":"2026020502003605300_BIB30","first-page":"1","volume":"46","year":"1994","journal-title":"Kidney Int"},{"key":"2026020502003605300_BIB31","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/1529-0131(199904)42:4<742::AID-ANR18>3.0.CO;2-I","volume":"42","year":"1999","journal-title":"Arthritis Rheum"},{"key":"2026020502003605300_BIB32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH656>3.0.CO;2-M","volume":"192","year":"2000","journal-title":"J Pathol"},{"key":"2026020502003605300_BIB33","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1046\/j.1523-1755.2002.00619.x","volume":"62","year":"2002","journal-title":"Kidney Int"},{"key":"2026020502003605300_BIB34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/art.20938","volume":"52","year":"2005","journal-title":"Arthritis Rheum"},{"key":"2026020502003605300_BIB35","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0046-8177(88)80088-1","volume":"19","year":"1988","journal-title":"Hum Pathol"},{"key":"2026020502003605300_BIB36","first-page":"7","volume":"11","year":"1994","journal-title":"Sarcoidosis"},{"key":"2026020502003605300_BIB37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1164\/rccm.200504-644OC","volume":"173","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502003605300_BIB38","first-page":"138S","volume":"103","year":"1993","journal-title":"Chest"},{"key":"2026020502003605300_BIB39","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1378\/chest.109.3_Supplement.5S","volume":"109","year":"1996","journal-title":"Chest"},{"key":"2026020502003605300_BIB40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s001090000105","volume":"78","year":"2000","journal-title":"J Mol Med"},{"key":"2026020502003605300_BIB41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tox.2005.10.016","volume":"218","year":"2006","journal-title":"Toxicology"},{"key":"2026020502003605300_BIB42","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.micinf.2005.10.027","volume":"8","year":"2006","journal-title":"Microbes Infect"},{"key":"2026020502003605300_BIB43","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1286-4579(03)00179-5","volume":"5","year":"2003","journal-title":"Microbes Infect"},{"key":"2026020502003605300_BIB44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1517\/14728222.6.1.21","volume":"6","year":"2002","journal-title":"Expert Opin Ther Targets"},{"key":"2026020502003605300_BIB45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/pr050248t","volume":"5","year":"2006","journal-title":"J Proteome Res"},{"key":"2026020502003605300_BIB46","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1101\/gr.3994105","volume":"15","year":"2005","journal-title":"Genome Res"},{"key":"2026020502003605300_BIB47","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1099\/mic.0.27284-0","volume":"150","year":"2004","journal-title":"Microbiology"},{"key":"2026020502003605300_BIB48","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.20030846","volume":"198","year":"2003","journal-title":"J Exp Med"},{"key":"2026020502003605300_BIB49","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1099\/00221287-147-2-459","volume":"147","year":"2001","journal-title":"Microbiol"},{"key":"2026020502003605300_BIB50","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1128\/IAI.74.2.1233-1242.2006","volume":"74","year":"2006","journal-title":"Infect Immun"},{"key":"2026020502003605300_BIB51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0928-8244(03)00223-2","volume":"39","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2026020502003605300_BIB52","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/IAI.72.2.937-948.2004","volume":"72","year":"2004","journal-title":"Infect Immun"},{"key":"2026020502003605300_BIB53","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1128\/IAI.73.6.3330-3341.2005","volume":"73","year":"2005","journal-title":"Infect Immun"},{"key":"2026020502003605300_BIB54","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1128\/IAI.71.12.6871-6883.2003","volume":"71","year":"2003","journal-title":"Infect Immun"},{"key":"2026020502003605300_BIB55","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1365-2249.2004.02490.x","volume":"136","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"2026020502003605300_BIB56","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1128\/IAI.72.11.6603-6614.2004","volume":"72","year":"2004","journal-title":"Infect Immun"},{"key":"2026020502003605300_BIB57","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.4049\/jimmunol.172.10.6272","volume":"172","year":"2004","journal-title":"J Immunol"},{"key":"2026020502003605300_BIB58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.micinf.2005.06.015","volume":"8","year":"2006","journal-title":"Microbes Infect"},{"key":"2026020502003605300_BIB59","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1128\/IAI.72.9.5315-5321.2004","volume":"72","year":"2004","journal-title":"Infect Immun"},{"key":"2026020502003605300_BIB60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tube.2003.12.003","volume":"84","year":"2004","journal-title":"Tuberculosis (Edinb)"},{"key":"2026020502003605300_BIB61","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/1615-9861(200104)1:4<574::AID-PROT574>3.0.CO;2-8","volume":"1","year":"2001","journal-title":"Proteomics"},{"key":"2026020502003605300_BIB62","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1099\/mic.0.27799-0","volume":"151","year":"2005","journal-title":"Microbiol"},{"key":"2026020502003605300_BIB63","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.micinf.2005.09.012","volume":"8","year":"2006","journal-title":"Microbes Infect"},{"key":"2026020502003605300_BIB64","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tube.2004.09.005","volume":"85","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"key":"2026020502003605300_BIB65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2796.2003.01073.x","volume":"253","year":"2003","journal-title":"J Intern Med"},{"key":"2026020502003605300_BIB66","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.20050842","volume":"201","year":"2005","journal-title":"J Exp Med"},{"key":"2026020502003605300_BIB67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1462-5822.2003.00288.x","volume":"5","year":"2003","journal-title":"Cell Microbiol"},{"key":"2026020502003605300_BIB68","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1165\/rcmb.2004-0080OC","volume":"31","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026020502003605300_BIB69","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1373\/clinchem.2005.060715","volume":"52","year":"2006","journal-title":"Clin Chem"},{"key":"2026020502003605300_BIB70","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1091\/mbc.e04-04-0329","volume":"16","year":"2005","journal-title":"Mol Biol Cell"},{"key":"2026020502003605300_BIB71","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/omi.2004.8.322","volume":"8","year":"2004","journal-title":"OMICS"},{"key":"2026020502003605300_BIB72","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1471-2105-6-239","volume":"6","year":"2005","journal-title":"BMC Bioinformatics"}],"container-title":["Proceedings of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/4\/1\/101\/66566609\/annalsats_4_1_101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/4\/1\/101\/66566609\/annalsats_4_1_101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:00:51Z","timestamp":1770274851000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/4\/1\/101\/8440258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,1]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,1,1]]},"published-print":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1513\/pats.200607-140jg","relation":{},"ISSN":["1546-3222","1943-5665"],"issn-type":[{"value":"1546-3222","type":"print"},{"value":"1943-5665","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,1]]},"published":{"date-parts":[[2007,1,1]]}}}