{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:46:18Z","timestamp":1791326778926,"version":"4.3.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bronchioles of the distal conducting airway are lined by a simple epithelium composed primarily of nonciliated secretory (Clara) cells and ciliated cells. These cells are long-lived in the normal lung; renewal is mediated by cells that constitute a nonclassical stem cell hierarchy. Within this type of hierarchy, facultative progenitor cells are responsible for normal epithelial maintenance and rare adult tissue-specific stem cells are activated only in response to depletion of the facultative progenitor cell pool. This organizational structure is a departure from the classical stem cell hierarchies that maintain rapidly renewing tissues such as the epithelium of the small intestine. This article compares cellular and molecular mechanisms of epithelial renewal in the relatively quiescent bronchiolar epithelium and in the mitotically active intestinal epithelium. Fundamental distinctions between stem cell hierarchies of slowly and rapidly renewing epithelia are highlighted and may provide insight into tissue-specific interpretation of signals that mediate repair in some tissues but lead to remodeling and chronic disease in other organ systems.<\/jats:p>","DOI":"10.1513\/pats.200711-167dr","type":"journal-article","created":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T19:58:33Z","timestamp":1207771113000},"page":"328-333","source":"Crossref","is-referenced-by-count":133,"title":["Maintenance and Repair of the Bronchiolar Epithelium"],"prefix":"10.1093","volume":"5","author":[{"given":"Barry R.","family":"Stripp","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"2026020502045350900_BIB1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/bies.10028","volume":"24","year":"2002","journal-title":"Bioessays"},{"key":"2026020502045350900_BIB2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","year":"2007","journal-title":"Nature"},{"key":"2026020502045350900_BIB3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature05659","volume":"445","year":"2007","journal-title":"Nature"},{"key":"2026020502045350900_BIB4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0002-9440(10)64727-X","volume":"156","year":"2000","journal-title":"Am J Pathol"},{"key":"2026020502045350900_BIB5","first-page":"246","volume":"35","year":"1976","journal-title":"Lab Invest"},{"key":"2026020502045350900_BIB6","first-page":"648","volume":"38","year":"1978","journal-title":"Lab Invest"},{"key":"2026020502045350900_BIB7","doi-asserted-by":"crossref","first-page":"L1523","DOI":"10.1152\/ajplung.2001.281.6.L1523","volume":"281","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026020502045350900_BIB8","doi-asserted-by":"crossref","first-page":"L1303","DOI":"10.1152\/ajplung.2001.281.5.L1303","volume":"281","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026020502045350900_BIB9","first-page":"L924","volume":"275","year":"1998","journal-title":"Am J Physiol"},{"key":"2026020502045350900_BIB10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.taap.2005.09.003","volume":"213","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026020502045350900_BIB11","first-page":"L348","volume":"275","year":"1998","journal-title":"Am J Physiol"},{"key":"2026020502045350900_BIB12","doi-asserted-by":"crossref","first-page":"L114","DOI":"10.1152\/ajplung.00014.2007","volume":"293","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026020502045350900_BIB13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1165\/rcmb.2004-0060OC","volume":"31","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026020502045350900_BIB14","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/S0002-9440(10)64338-6","volume":"162","year":"2003","journal-title":"Am J Pathol"},{"key":"2026020502045350900_BIB15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1164\/arrd.1978.118.4.787","volume":"118","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"2026020502045350900_BIB16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.yexcr.2005.02.022","volume":"306","year":"2005","journal-title":"Exp Cell Res"},{"key":"2026020502045350900_BIB17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(04)00255-7","volume":"116","year":"2004","journal-title":"Cell"},{"key":"2026020502045350900_BIB18","first-page":"3061","volume":"46","year":"1986","journal-title":"Cancer Res"},{"key":"2026020502045350900_BIB19","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","volume":"61","year":"1990","journal-title":"Cell"},{"key":"2026020502045350900_BIB20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","volume":"57","year":"1989","journal-title":"Cell"},{"key":"2026020502045350900_BIB21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.1092436","volume":"303","year":"2004","journal-title":"Science"},{"key":"2026020502045350900_BIB22","doi-asserted-by":"crossref","first-page":"12601","DOI":"10.1073\/pnas.230237997","volume":"97","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020502045350900_BIB23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1165\/rcmb.F296","volume":"32","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026020502045350900_BIB24","first-page":"1104","volume":"3","year":"2004","journal-title":"Cell Cycle"},{"key":"2026020502045350900_BIB25","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nature05537","volume":"445","year":"2007","journal-title":"Nature"},{"key":"2026020502045350900_BIB26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.21900","volume":"33","year":"2001","journal-title":"Hepatology"},{"key":"2026020502045350900_BIB27","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.diabres.2003.09.015","volume":"66","year":"2004","journal-title":"Diabetes Res Clin Pract"},{"key":"2026020502045350900_BIB28","first-page":"558","volume":"86","year":"1977","journal-title":"Am J Pathol"},{"key":"2026020502045350900_BIB29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","volume":"429","year":"2004","journal-title":"Nature"},{"key":"2026020502045350900_BIB30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0002-9440(10)64169-7","volume":"161","year":"2002","journal-title":"Am J Pathol"},{"key":"2026020502045350900_BIB31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1165\/ajrcmb.24.6.4498","volume":"24","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026020502045350900_BIB32","doi-asserted-by":"crossref","first-page":"L791","DOI":"10.1152\/ajpcell.1995.269.3.C791","volume":"269","year":"1995","journal-title":"Am J Physiol"},{"key":"2026020502045350900_BIB33","doi-asserted-by":"crossref","first-page":"L1256","DOI":"10.1152\/ajplung.2000.278.6.L1256","volume":"278","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026020502045350900_BIB34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2005.03.032","volume":"121","year":"2005","journal-title":"Cell"},{"key":"2026020502045350900_BIB35","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ncb1660","volume":"9","year":"2007","journal-title":"Nat Cell Biol"},{"key":"2026020502045350900_BIB36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng1928","volume":"39","year":"2007","journal-title":"Nat Genet"},{"key":"2026020502045350900_BIB37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/156652406776894527","volume":"6","year":"2006","journal-title":"Curr Mol Med"},{"key":"2026020502045350900_BIB38","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1101\/gad.287404","volume":"18","year":"2004","journal-title":"Genes Dev"},{"key":"2026020502045350900_BIB39","year":"2006","journal-title":"Nat Immunol"},{"key":"2026020502045350900_BIB40","year":"2006","journal-title":"Nat Immunol"},{"key":"2026020502045350900_BIB41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nm1339","volume":"12","year":"2006","journal-title":"Nat Med"},{"key":"2026020502045350900_BIB42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature01593","volume":"423","year":"2003","journal-title":"Nature"},{"key":"2026020502045350900_BIB43","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0092-8674(00)81631-1","volume":"95","year":"1998","journal-title":"Cell"},{"key":"2026020502045350900_BIB44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","volume":"105","year":"2001","journal-title":"Cell"},{"key":"2026020502045350900_BIB45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/dbio.1998.9140","volume":"207","year":"1999","journal-title":"Dev Biol"},{"key":"2026020502045350900_BIB46","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1242\/dev.01052","volume":"131","year":"2004","journal-title":"Development"},{"key":"2026020502045350900_BIB47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/jbiol3","volume":"3","year":"2004","journal-title":"J Biol"},{"key":"2026020502045350900_BIB48","doi-asserted-by":"crossref","first-page":"40231","DOI":"10.1074\/jbc.M305892200","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"2026020502045350900_BIB49","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ydbio.2005.04.014","volume":"283","year":"2005","journal-title":"Dev Biol"},{"key":"2026020502045350900_BIB50","doi-asserted-by":"crossref","first-page":"10063","DOI":"10.1073\/pnas.0703004104","volume":"104","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020502045350900_BIB51","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1083\/jcb.200309042","volume":"163","year":"2003","journal-title":"J Cell Biol"},{"key":"2026020502045350900_BIB52","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1164\/ajrccm.164.supplement_2.2106061","volume":"164","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502045350900_BIB53","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1164\/ajrccm.160.3.9803113","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502045350900_BIB54","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/01.TP.0000158354.39635.AB","volume":"79","year":"2005","journal-title":"Transplantation"},{"key":"2026020502045350900_BIB55","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/pmic.200500105","volume":"6","year":"2006","journal-title":"Proteomics"},{"key":"2026020502045350900_BIB56","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1749-6632.2000.tb05520.x","volume":"923","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"2026020502045350900_BIB57","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/jnci\/djm136","volume":"99","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"2026020502045350900_BIB58","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1101\/gad.943001","volume":"15","year":"2001","journal-title":"Genes Dev"}],"container-title":["Proceedings of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/5\/3\/328\/66583883\/annalsats_5_3_328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/5\/3\/328\/66583883\/annalsats_5_3_328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:05:28Z","timestamp":1770275128000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/5\/3\/328\/8441562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,15]]},"published-print":{"date-parts":[[2008,4,15]]}},"URL":"https:\/\/doi.org\/10.1513\/pats.200711-167dr","relation":{},"ISSN":["1546-3222","1943-5665"],"issn-type":[{"value":"1546-3222","type":"print"},{"value":"1943-5665","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,4]]},"published":{"date-parts":[[2008,4]]}}}