{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:23:47Z","timestamp":1791156227955,"version":"4.1.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral muscle dysfunction associated with chronic diseases is undeniably a growing problem as one of its main causes, chronic obstructive pulmonary disease (COPD), progresses. Among others, muscle atrophy is one component building the concept of muscle dysfunction. Muscle atrophy has a significant impact on patient clinical status, independent of the impairment in lung function. A lot of effort has been devoted lately to increasing our understanding of the relationship between COPD and the initiation and the development of muscle atrophy. A growing body of evidence is showing that the ubiquitin-proteasome system, an ATP-dependent proteolytic pathway, is playing a crucial role in the cascade leading to degradation of contractile proteins, thus promoting the development of muscle atrophy. Interestingly, this system is also involved in essential cellular processes such as response to hypoxemia and muscle tissue regeneration. In this review, existing evidence linking the activity of the ubiquitin-proteasome system and the cellular events taking place in respiratory and peripheral muscles of patients with COPD are reported. Based on this information, the reader should be able to understand the essential role of this pathway in the context of muscle homeostasis and to picture the coming research in this area.<\/jats:p>","DOI":"10.1513\/pats.200906-051js","type":"journal-article","created":{"date-parts":[[2010,2,16]],"date-time":"2010-02-16T15:23:04Z","timestamp":1266333784000},"page":"84-90","source":"Crossref","is-referenced-by-count":27,"title":["Ubiquitination and Proteolysis in Limb and Respiratory Muscles of Patients with Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"7","author":[{"given":"Richard","family":"Debigar\u00e9","sequence":"first","affiliation":[{"name":"Centre de recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude H.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Centre de recherche du CHUQ, Pavillon CHUL, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Maltais","sequence":"additional","affiliation":[{"name":"Centre de recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Qu\u00e9bec, Canada ; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,15]]},"reference":[{"key":"2026020502110728200_BIB1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/15412550802237531","volume":"5","year":"2008","journal-title":"COPD: Journal of Chronic Obstructive Pulmonary Disease"},{"key":"2026020502110728200_BIB2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1164\/ajrccm.153.3.8630582","volume":"153","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/rmed.2000.0829","volume":"94","year":"2000","journal-title":"Respir Med"},{"key":"2026020502110728200_BIB4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1164\/rccm.2107031","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/thorax.55.10.848","volume":"55","year":"2000","journal-title":"Thorax"},{"key":"2026020502110728200_BIB6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1164\/ajrccm.158.2.9711023","volume":"158","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1183\/09031936.97.10020417","volume":"10","year":"1997","journal-title":"Eur Respir J"},{"key":"2026020502110728200_BIB8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","volume":"80","year":"2000","journal-title":"Physiol Rev"},{"key":"2026020502110728200_BIB9","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1369\/jhc.6R6995.2006","volume":"54","year":"2006","journal-title":"J Histochem Cytochem"},{"key":"2026020502110728200_BIB10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.1998.78.2.359","volume":"78","year":"1998","journal-title":"Physiol Rev"},{"key":"2026020502110728200_BIB11","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.biocel.2005.04.018","volume":"37","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"2026020502110728200_BIB12","first-page":"271","volume":"6","year":"2003","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2026020502110728200_BIB13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1096\/fj.03-0610com","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"2026020502110728200_BIB14","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJM199612193352507","volume":"335","year":"1996","journal-title":"N Engl J Med"},{"key":"2026020502110728200_BIB15","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1055\/s-2007-1024846","volume":"11","year":"1990","journal-title":"Int J Sports Med"},{"key":"2026020502110728200_BIB16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.immunol.17.1.739","volume":"17","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"2026020502110728200_BIB17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","volume":"82","year":"2002","journal-title":"Physiol Rev"},{"key":"2026020502110728200_BIB18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.biochem.70.1.503","volume":"70","year":"2001","journal-title":"Annu Rev Biochem"},{"key":"2026020502110728200_BIB19","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.1152\/ajpcell.1994.267.1.C39","volume":"267","year":"1994","journal-title":"Am J Physiol"},{"key":"2026020502110728200_BIB20","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1172\/JCI7300","volume":"104","year":"1999","journal-title":"J Clin Invest"},{"key":"2026020502110728200_BIB21","doi-asserted-by":"crossref","first-page":"25216","DOI":"10.1074\/jbc.273.39.25216","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"2026020502110728200_BIB22","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","volume":"294","year":"2001","journal-title":"Science"},{"key":"2026020502110728200_BIB23","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020502110728200_BIB24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1006\/jmbi.2001.4448","volume":"306","year":"2001","journal-title":"J Mol Biol"},{"key":"2026020502110728200_BIB25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jmb.2005.05.021","volume":"350","year":"2005","journal-title":"J Mol Biol"},{"key":"2026020502110728200_BIB26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","volume":"117","year":"2004","journal-title":"Cell"},{"key":"2026020502110728200_BIB27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","volume":"14","year":"2004","journal-title":"Mol Cell"},{"key":"2026020502110728200_BIB28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","volume":"119","year":"2004","journal-title":"Cell"},{"key":"2026020502110728200_BIB29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3835(02)00006-X","volume":"180","year":"2002","journal-title":"Cancer Lett"},{"key":"2026020502110728200_BIB30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mus.20442","volume":"33","year":"2006","journal-title":"Muscle Nerve"},{"key":"2026020502110728200_BIB31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.1147949","volume":"318","year":"2007","journal-title":"Science"},{"key":"2026020502110728200_BIB32","doi-asserted-by":"crossref","first-page":"C806","DOI":"10.1152\/ajpcell.00129.2003","volume":"285","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026020502110728200_BIB33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.04-2364com","volume":"19","year":"2005","journal-title":"FASEB J"},{"key":"2026020502110728200_BIB34","doi-asserted-by":"crossref","first-page":"R1165","DOI":"10.1152\/ajpregu.2000.279.4.R1165","volume":"279","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2026020502110728200_BIB35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/mus.20743","volume":"35","year":"2007","journal-title":"Muscle Nerve"},{"key":"2026020502110728200_BIB36","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.febslet.2009.04.006","volume":"583","year":"2009","journal-title":"FEBS Lett"},{"key":"2026020502110728200_BIB37","first-page":"S1","volume":"159","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB38","doi-asserted-by":"crossref","first-page":"26690","DOI":"10.1074\/jbc.271.43.26690","volume":"271","year":"1996","journal-title":"J Biol Chem"},{"key":"2026020502110728200_BIB39","doi-asserted-by":"crossref","first-page":"E762","DOI":"10.1152\/ajpendo.90226.2008","volume":"295","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026020502110728200_BIB40","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2007.11.004","volume":"6","year":"2007","journal-title":"Cell Metab"},{"key":"2026020502110728200_BIB41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI18330","volume":"113","year":"2004","journal-title":"J Clin Invest"},{"key":"2026020502110728200_BIB42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1164\/rccm.200605-704OC","volume":"176","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/15412550801940457","volume":"5","year":"2008","journal-title":"COPD: Journal of Chronic Obstructive Pulmonary Disease"},{"key":"2026020502110728200_BIB44","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1152\/japplphysiol.00577.2006","volume":"102","year":"2007","journal-title":"J Appl Physiol"},{"key":"2026020502110728200_BIB45","doi-asserted-by":"crossref","first-page":"E843","DOI":"10.1152\/ajpendo.00301.2007","volume":"293","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026020502110728200_BIB46"},{"key":"2026020502110728200_BIB47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1096\/fj.06-6665com","volume":"21","year":"2007","journal-title":"FASEB J"},{"key":"2026020502110728200_BIB48","doi-asserted-by":"crossref","first-page":"C579","DOI":"10.1152\/ajpcell.1997.273.2.C579","volume":"273","year":"1997","journal-title":"Am J Physiol"},{"key":"2026020502110728200_BIB49","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1164\/rccm.2108013","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB50","first-page":"159","volume":"1","year":"2000","journal-title":"Respir Res"},{"key":"2026020502110728200_BIB51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00008483-199811000-00005","volume":"18","year":"1998","journal-title":"J Cardiopulm Rehabil"},{"key":"2026020502110728200_BIB52","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1097\/00005768-199810000-00001","volume":"30","year":"1998","journal-title":"Med Sci Sports Exerc"},{"key":"2026020502110728200_BIB53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jcp.2008.057190","volume":"62","year":"2009","journal-title":"J Clin Pathol"},{"key":"2026020502110728200_BIB54","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJM199712183372503","volume":"337","year":"1997","journal-title":"N Engl J Med"},{"key":"2026020502110728200_BIB55","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1056\/NEJMoa070447","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"key":"2026020502110728200_BIB56","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1164\/rccm.200502-262OC","volume":"172","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB57","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1164\/rccm.200605-721OC","volume":"174","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB58","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1152\/japplphysiol.00194.2009","volume":"107","year":"2009","journal-title":"J Appl Physiol"},{"key":"2026020502110728200_BIB59","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1164\/ajrccm.159.3.9807034","volume":"159","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB60","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/thx.47.2.70","volume":"47","year":"1992","journal-title":"Thorax"},{"key":"2026020502110728200_BIB61","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1096\/fj.03-1228fje","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"2026020502110728200_BIB62","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1152\/japplphysiol.01445.2006","volume":"103","year":"2007","journal-title":"J Appl Physiol"},{"key":"2026020502110728200_BIB63","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.semcdb.2005.07.006","volume":"16","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"2026020502110728200_BIB64","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1074\/jbc.M411346200","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"2026020502110728200_BIB65","doi-asserted-by":"crossref","first-page":"e4973","DOI":"10.1371\/journal.pone.0004973","volume":"4","year":"2009","journal-title":"PLoS One"},{"key":"2026020502110728200_BIB66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2091-6-27","volume":"6","year":"2005","journal-title":"BMC Biochem"},{"key":"2026020502110728200_BIB67","doi-asserted-by":"crossref","first-page":"43524","DOI":"10.1074\/jbc.M108017200","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"2026020502110728200_BIB68","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/j.1460-2075.1996.tb00524.x","volume":"15","year":"1996","journal-title":"EMBO J"},{"key":"2026020502110728200_BIB69","doi-asserted-by":"crossref","first-page":"16332","DOI":"10.1074\/jbc.M313931200","volume":"279","year":"2004","journal-title":"J Biol Chem"},{"key":"2026020502110728200_BIB70","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2091-8-S1-S7","volume":"8","year":"2007","journal-title":"BMC Biochem"},{"key":"2026020502110728200_BIB71","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pharmthera.2005.06.007","volume":"109","year":"2006","journal-title":"Pharmacol Ther"},{"key":"2026020502110728200_BIB72","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1164\/rccm.200305-617OC","volume":"170","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2026020502110728200_BIB73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/bbrc.2000.2398","volume":"270","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"2026020502110728200_BIB74","doi-asserted-by":"crossref","first-page":"L1260","DOI":"10.1152\/ajplung.00035.2008","volume":"294","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026020502110728200_BIB75","first-page":"381","volume":"13","year":"2005","journal-title":"Support Care Cancer"},{"key":"2026020502110728200_BIB76","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF03401576","volume":"1","year":"1995","journal-title":"Mol Med"},{"key":"2026020502110728200_BIB77","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1200\/JCO.1995.13.11.2856","volume":"13","year":"1995","journal-title":"J Clin Oncol"},{"key":"2026020502110728200_BIB78","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.nut.2008.09.002","volume":"25","year":"2009","journal-title":"Nutrition"},{"key":"2026020502110728200_BIB79","first-page":"487","volume":"11","year":"2008","journal-title":"Curr Opin Drug Discov Devel"},{"key":"2026020502110728200_BIB80","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1210\/en.2008-0959","volume":"150","year":"2009","journal-title":"Endocrinology"}],"container-title":["Proceedings of the American Thoracic Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/7\/1\/84\/66579662\/annalsats_7_1_84.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/annalsats\/article-pdf\/7\/1\/84\/66579662\/annalsats_7_1_84.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:11:28Z","timestamp":1770275488000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/annalsats\/article\/7\/1\/84\/8441313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2,15]]},"published-print":{"date-parts":[[2010,2,15]]}},"URL":"https:\/\/doi.org\/10.1513\/pats.200906-051js","relation":{},"ISSN":["1546-3222","1943-5665"],"issn-type":[{"value":"1546-3222","type":"print"},{"value":"1943-5665","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,2]]},"published":{"date-parts":[[2010,2]]}}}