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Clinical presentation depends on the infectious load, underlying immune status, and lung function. The preferred diagnostic methods and treatment options vary with clinical scenario and severity of illness. New diagnostic tools and treatment options are now available in clinical practice. We present an overview of this important endemic mycosis with emphasis on diagnosis and treatment recommendations for the different clinical syndromes of histoplasmosis.<\/jats:p>","DOI":"10.1513\/pats.200907-069al","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T14:30:46Z","timestamp":1273674646000},"page":"169-172","source":"Crossref","is-referenced-by-count":87,"title":["Histoplasmosis"],"prefix":"10.1093","volume":"7","author":[{"given":"Kenneth S.","family":"Knox","sequence":"first","affiliation":[{"name":"University of Arizona College of Medicine and Southern Arizona VA HealthCare System, Tucson, Arizona; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi A.","family":"Hage","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine and Roudebush Veterans' Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, 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