{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:46:06Z","timestamp":1771364766596,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium (Be) exposure in the workplace. It is characterized by the accumulation of Be-specific CD4+ T cells in the lung as well as persistent lung inflammation, culminating in the development of lung fibrosis. CBD occurs in 2 to 16% of Be-exposed workers depending on the individuals' genetic susceptibility and the characteristics of the exposure. Genetic susceptibility to Be-induced disease has been linked to major histocompatibility complex class II molecules. In particular, HLA-DP alleles possessing a glutamic acid at the 69th position of the \u03b2-chain (\u03b2Glu69) are most strongly linked to disease susceptibility. The HLA-DP alleles that present Be to T cells match those implicated in the genetic susceptibility, suggesting that the HLA contribution to disease is based on the ability of those molecules to bind and present Be to T cells. However, the structural features of \u03b2Glu69-containing HLA-DP molecules that explain the disease association remain unknown. We have recently crystallized HLA-DP2, which is the most prevalent of the \u03b2Glu69-containing HLA-DP molecules. Its unique structure, which includes surface exposure of \u03b2Glu69, provides an explanation of the genetic linkage between \u03b2Glu69-containing HLA-DP alleles and Be-induced disease.<\/jats:p>","DOI":"10.1513\/pats.201002-022rm","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T12:13:41Z","timestamp":1272456821000},"page":"126-129","source":"Crossref","is-referenced-by-count":16,"title":["Linking Genetic Susceptibility and T Cell Activation in Beryllium-induced Disease"],"prefix":"10.1093","volume":"7","author":[{"given":"Michael T.","family":"Falta","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Denver, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie A.","family":"Bowerman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Denver, Aurora, 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