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Consistent with these changes, non\u2013AIDS-related illnesses account for the majority of ICU admissions in more recent studies, in contrast to earlier eras of the AIDS epidemic. Although mortality after ICU admission has improved significantly since the earliest HIV era, it remains substantial. In this article, we discuss the current state of knowledge regarding the impact of ART on incidence, etiology, and outcomes of critical illness among HIV-infected patients. In addition, we consider issues related to administration of ART in the ICU and identify important areas of future research.<\/jats:p>","DOI":"10.1513\/pats.201009-060wr","type":"journal-article","created":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T02:24:12Z","timestamp":1307499852000},"page":"301-307","source":"Crossref","is-referenced-by-count":27,"title":["Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy"],"prefix":"10.1093","volume":"8","author":[{"given":"Kathleen M.","family":"Akg\u00fcn","sequence":"first","affiliation":[{"name":"VA Connecticut Healthcare System, Department of Internal Medicine, West Haven, Connecticut"},{"name":"Pulmonary & Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary & Critical Care 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