{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:15:45Z","timestamp":1794244545068,"version":"4.9.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The nuclear factor (NF)-\u03baB is considered the master regulator of inflammatory responses. Studies in mouse models have established this transcription factor as an important mediator of many inflammatory disease states, including pulmonary diseases such as acute lung injury and acute respiratory distress syndrome. Endothelial cells provide the first barrier for leukocytes migrating to the inflamed sites and hence offer an attractive cellular context for targeting NF-\u03baB for treatment of these diseases. However, recent studies showing that NF-\u03baB also plays an important role in resolution phase of inflammation and in tissue repair and homeostasis have challenged the view of therapeutic inhibition of NF-\u03baB. This article reviews the regulation of NF-\u03baB in the context of endothelial cell signaling and provides a perspective on why \u201cdampening\u201d rather than \u201cabolishing\u201d NF-\u03baB activation may be a safe and effective treatment strategy for inflammation-associated pulmonary and other inflammatory diseases.<\/jats:p>","DOI":"10.1513\/pats.201101-009mw","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T03:24:46Z","timestamp":1320290686000},"page":"497-503","source":"Crossref","is-referenced-by-count":191,"title":["Blocking NF-\u03baB: An Inflammatory Issue"],"prefix":"10.1093","volume":"8","author":[{"given":"Arshad","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Neonatology), Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 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