{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:15:23Z","timestamp":1778346923434,"version":"3.51.4"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"7","funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["EFRE-0400147"],"award-info":[{"award-number":["EFRE-0400147"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This paper presents an optimization-based control scheme for a novel left ventricular assist device. This cardiac support system consists of two pumps connected in series and a buffer reservoir in between them. This novel concept for relieving the left ventricle is designed to allow the pre- and afterload on the heart to be explicitly adjusted and independently of each other. The first pump controls the preload of the heart with a known physiological controller. With an iterative model-based optimization, the afterload is minimized by the second pump while complying with all constraints. The proof of the control concept and a comparison to the classical single pump left-sided cardiac support is performed on a hardware-in-the-loop test bench. The results show that with the new left ventricular assist device concept, the afterload can be reduced compared to the classical cardiac support.<\/jats:p>","DOI":"10.1515\/auto-2021-0031","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T23:38:19Z","timestamp":1625096299000},"page":"619-631","source":"Crossref","is-referenced-by-count":3,"title":["Model based optimization of a novel ventricular assist device"],"prefix":"10.1515","volume":"69","author":[{"given":"Tobias","family":"Salesch","sequence":"first","affiliation":[{"name":"Institute of Automatic Control , RWTH Aachen University , Aachen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Gesenhues","sequence":"additional","affiliation":[{"name":"Institute of Automatic Control , RWTH Aachen University , Aachen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moriz","family":"Habigt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology , RWTH Aachen University Hospital , Aachen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mare","family":"Mechelinck","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology , RWTH Aachen University Hospital , Aachen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Hein","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology , RWTH Aachen University Hospital , Aachen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Abel","sequence":"additional","affiliation":[{"name":"Institute of Automatic Control , RWTH Aachen University , Aachen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"2023033110595257646_j_auto-2021-0031_ref_001_w2aab3b7d723b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"B. 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