{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:43:07Z","timestamp":1719225787708},"reference-count":0,"publisher":"Index Copernicus","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Two of the key problems plaguing humanity \u2013 aging and carcinogenesis \u2013 are inexorably linked. While their nature seems different, their mechanisms have a lot in common. Evidence suggests that aging is the result of spontaneous synthesis and accumulation of improperly folded proteins in cells, leading to a variety of pathologies. As for carcinogenesis, it is tied to genetic mutations \u2013 permanent, covalent changes in the DNA. Both processes are random in character; however, unlike mutations, the accumulation of malformed proteins is not genetically determined. Instead, control over this process hinges upon regulating the protein exchange rate \u2013 a phenomenon that seems a likely candidate for the basic aging control mechanism. Although mutations themselves may be counteracted in a controlled manner, their effects typically cannot. The mechanisms of aging and carcinogenesis, while functionally different, remain correlated: an aging cell is rendered more susceptible to mutational changes. The rapidly growing body of information regarding aging and carcinogenesis enables a systemic approach to both these phenomena \u2013 an approach that is attempted in this review.<\/jats:p>","DOI":"10.1515\/bams-2014-0012","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T08:00:00Z","timestamp":1409644800000},"page":"101-115","source":"Crossref","is-referenced-by-count":1,"title":["Attempt at a systemic outlook on aging and carcinogenesis"],"prefix":"10.5604","volume":"10","author":[{"given":"Monika","family":"Piwowar","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Telemedicine, Jagiellonian University \u2013 Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Dygut","sequence":"additional","affiliation":[{"name":"Hospital in Przemy\u015bl, Przemy\u015bl, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Piwowar","sequence":"additional","affiliation":[{"name":"AGH University of Science and Technology, Pawilon B-1, Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Konieczny","sequence":"additional","affiliation":[{"name":"Chair of Medical Biochemistry, Jagiellonian University \u2013 Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Roterman","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Telemedicine, Jagiellonian University \u2013 Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","published-online":{"date-parts":[[2014,9,2]]},"container-title":["Bio-Algorithms and Med-Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bams-2014-0012\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bams-2014-0012\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:08:59Z","timestamp":1719223739000},"score":1,"resource":{"primary":{"URL":"https:\/\/bamsjournal.com\/resources\/html\/article\/details?id=617566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,2]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,9,2]]},"published-print":{"date-parts":[[2014,9,30]]}},"alternative-id":["10.1515\/bams-2014-0012"],"URL":"https:\/\/doi.org\/10.1515\/bams-2014-0012","relation":{},"ISSN":["1896-530X","1895-9091"],"issn-type":[{"value":"1896-530X","type":"electronic"},{"value":"1895-9091","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,2]]}}}