{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:52:15Z","timestamp":1753887135895,"version":"3.41.2"},"reference-count":11,"publisher":"Index Copernicus","issue":"3","funder":[{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","award":["K\/ZDS\/006363, K\/ZDS\/006366"],"award-info":[{"award-number":["K\/ZDS\/006363, K\/ZDS\/006366"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The structure of amyloid A\u03b2(1-41) is the object of many papers due to the neurodegenerative processes induced by this amyloid. One of the ways to investigate the possible structural forms other than the amyloid is to incorporate the fragment of this peptide into the chain of immunoglobulin. Fragment A\u03b2(18-41) presented within the CDR3 loop region of a shark immunoglobulin new antigen receptor single-variable domain antibody is the object of this analysis. The structure of this hybrid is available in the PDB and analyzed based on the fuzzy oil drop model. The aim is to define the status of this fragment, revealing the possible fitting to the ordered form of the hydrophobic core. Simultaneously, the verification of the predisposition to complexation is possible.<\/jats:p>","DOI":"10.1515\/bams-2018-0028","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T09:01:15Z","timestamp":1538211675000},"source":"Crossref","is-referenced-by-count":0,"title":["Fragment A\u03b2(18-41) presented within the CDR3 loop region of a shark immunoglobulin new antigen receptor single-variable domain antibody analyzed based on the fuzzy oil drop model"],"prefix":"10.5604","volume":"14","author":[{"given":"Mateusz","family":"Banach","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Telemedicine , Jagiellonian University Medical College , 31-530 Krakow, \u0141azarza 16 , Krakow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Konieczny","sequence":"additional","affiliation":[{"name":"Chair of Medical Biochemistry , Jagiellonian University Medical College , 31-034 Krakow, Kopernika 7 , Krakow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdzis\u0142aw","family":"Wi\u015bniowski","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Telemedicine , Jagiellonian University Medical College , 31-530 Krakow, \u0141azarza 16 , Krakow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Roterman","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Telemedicine , Jagiellonian University Medical College , 31-530 Krakow, \u0141azarza 16 , Krakow , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","published-online":{"date-parts":[[2018,9,29]]},"reference":[{"key":"2023010916433772348_j_bams-2018-0028_ref_001_w2aab3b7b4b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Berchtold NC, Cotman CW. Evolution in the conceptualization of dementia and Alzheimer\u2019s disease: Greco-Roman period to the 1960s. Neurobiol Aging 1998;19:173\u201389.966199210.1016\/S0197-4580(98)00052-9","DOI":"10.1016\/S0197-4580(98)00052-9"},{"key":"2023010916433772348_j_bams-2018-0028_ref_002_w2aab3b7b4b1b6b1ab1b5b2Aa","doi-asserted-by":"crossref","unstructured":"Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer\u2019s disease in the United States and the public health impact of delaying disease onset. Am J Public Health 1998;88:1337\u201342.10.2105\/AJPH.88.9.13379736873","DOI":"10.2105\/AJPH.88.9.1337"},{"key":"2023010916433772348_j_bams-2018-0028_ref_003_w2aab3b7b4b1b6b1ab1b5b3Aa","doi-asserted-by":"crossref","unstructured":"Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi MH, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer\u2019s disease. Alzheimers Dementia 2007;3:186\u201391.10.1016\/j.jalz.2007.04.381","DOI":"10.1016\/j.jalz.2007.04.381"},{"key":"2023010916433772348_j_bams-2018-0028_ref_004_w2aab3b7b4b1b6b1ab1b5b4Aa","doi-asserted-by":"crossref","unstructured":"Streltsov VA, Varghese JN, Masters CL, Nuttall SD. Crystal structure of the amyloid-\u03b2 p3 fragment provides a model for oligomer formation in Alzheimer\u2019s disease. J Neurosci 2011;31:1419\u201326.2127342610.1523\/JNEUROSCI.4259-10.2011","DOI":"10.1523\/JNEUROSCI.4259-10.2011"},{"key":"2023010916433772348_j_bams-2018-0028_ref_005_w2aab3b7b4b1b6b1ab1b5b5Aa","doi-asserted-by":"crossref","unstructured":"Tycko R. Indirect detection in solid state NMR: an illustrious history and a bright future. J Magn Reson 2018;288:122\u20133.10.1016\/j.jmr.2018.02.014","DOI":"10.1016\/j.jmr.2018.02.014"},{"key":"2023010916433772348_j_bams-2018-0028_ref_006_w2aab3b7b4b1b6b1ab1b5b6Aa","doi-asserted-by":"crossref","unstructured":"Tycko R. Alzheimer\u2019s disease: structure of aggregates revealed. Nature 2016;537:492\u20133.2762637610.1038\/nature19470","DOI":"10.1038\/nature19470"},{"key":"2023010916433772348_j_bams-2018-0028_ref_007_w2aab3b7b4b1b6b1ab1b5b7Aa","doi-asserted-by":"crossref","unstructured":"Kalinowska B, Banach M, Konieczny L, Roterman I. Application of divergence entropy to characterize the structure of the hydrophobic core in DNA interacting proteins. Entropy 2015;17:1477\u2013507.10.3390\/e17031477","DOI":"10.3390\/e17031477"},{"key":"2023010916433772348_j_bams-2018-0028_ref_008_w2aab3b7b4b1b6b1ab1b5b8Aa","doi-asserted-by":"crossref","unstructured":"Kullback S, Leibler RA. On information and sufficiency. Ann Math Stat 1951;22:79\u201386.10.1214\/aoms\/1177729694","DOI":"10.1214\/aoms\/1177729694"},{"key":"2023010916433772348_j_bams-2018-0028_ref_009_w2aab3b7b4b1b6b1ab1b5b9Aa","unstructured":"Du\u0142ak D, Banach M, Gadza\u0142a M, Konieczny L, Roterman I. Structural analysis of the A\u03b2(15-40) amyloid fibrils. Submitted for publication."},{"key":"2023010916433772348_j_bams-2018-0028_ref_010_w2aab3b7b4b1b6b1ab1b5c10Aa","unstructured":"Du\u0142ak D, Banach M, Gadza\u0142a M, Konieczny L, Roterman I. Structural analysis of A\u03b2(1-40) amyloid. Submitted for publication."},{"key":"2023010916433772348_j_bams-2018-0028_ref_011_w2aab3b7b4b1b6b1ab1b5c11Aa","unstructured":"Du\u0142ak D, Banach M, Gadza\u0142a M, Konieczny L, Roterman I. Structural analysis of A\u03b2(11-42) amyloid. Submitted for publication."}],"container-title":["Bio-Algorithms and Med-Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/bams.2018.14.issue-3\/bams-2018-0028\/bams-2018-0028.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bams-2018-0028\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bams-2018-0028\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:08:13Z","timestamp":1719223693000},"score":1,"resource":{"primary":{"URL":"https:\/\/bamsjournal.com\/resources\/html\/article\/details?id=617657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,10,4]]},"published-print":{"date-parts":[[2018,9,25]]}},"alternative-id":["10.1515\/bams-2018-0028"],"URL":"https:\/\/doi.org\/10.1515\/bams-2018-0028","relation":{},"ISSN":["1896-530X","1895-9091"],"issn-type":[{"type":"electronic","value":"1896-530X"},{"type":"print","value":"1895-9091"}],"subject":[],"published":{"date-parts":[[2018,9,1]]},"article-number":"20180028"}}