{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:37:08Z","timestamp":1778636228278,"version":"3.51.4"},"reference-count":177,"publisher":"Index Copernicus","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The members of the mitochondrial carrier family, also known as solute carrier family 25 (SLC25), are transmembrane proteins involved in the translocation of a plethora of small molecules between the mitochondrial intermembrane space and the matrix. These transporters are characterized by three homologous domains structure and a transport mechanism that involves the transition between different conformations. Mutations in regions critical for these transporters\u2019 function often cause several diseases, given the crucial role of these proteins in the mitochondrial homeostasis. Experimental studies can be problematic in the case of membrane proteins, in particular concerning the characterization of the structure\u2013function relationships. For this reason, computational methods are often applied in order to develop new hypotheses or to support\/explain experimental evidence. Here the computational analyses carried out on the SLC25 members are reviewed, describing the main techniques used and the outcome in terms of improved knowledge of the transport mechanism. Potential future applications on this protein family of more recent and advanced <jats:italic>in silico<\/jats:italic> methods are also suggested.<\/jats:p>","DOI":"10.1515\/bams-2021-0018","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T01:19:43Z","timestamp":1619572783000},"page":"65-78","source":"Crossref","is-referenced-by-count":2,"title":["Computational studies of the mitochondrial carrier family SLC25. Present status and future perspectives"],"prefix":"10.5604","volume":"17","author":[{"given":"Andrea","family":"Pasquadibisceglie","sequence":"first","affiliation":[{"name":"Department of Sciences , Roma Tre University , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Polticelli","sequence":"additional","affiliation":[{"name":"Department of Sciences , Roma Tre University , Rome , Italy"},{"name":"National Institute of Nuclear Physics, Roma Tre Section , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"2021071720165889906_j_bams-2021-0018_ref_001_w2aab3b7d305b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Palmieri, F. Mitochondrial transporters of the SLC25 family and associated diseases: a review. 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