{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T09:51:50Z","timestamp":1648806710154},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Over the last decade, advances in high-throughput technologies\nhave resulted in a flood of new biological data. Here, individual\nsamples can extend up into terabyte size. While potential applications\nare broad, ranging from biotechnology to medical applications, the\nanalysis of these datasets poses massive challenges.\nIn order to make use of the produced terabytes of data, these datasets need to\nbe integrated, need to be mapped onto existing biological knowledge,\nand need to be explored by experts.<\/jats:p>\n               <jats:p>We present UniPAX and BiNA, a scalable system for the integration and analysis\nof high-throughput data (genomics, transcriptomics, proteomics, and\nmetabolomics) in a network context. A central data warehouse holds the core\ndataset. A flexible middleware can execute custom queries on this dataset and\ncommunicate with our visual analytics tool BiNA, the Biological Network\nAnalyzer. We demonstrate how the combination of these tools permits an efficient\nanalysis of large-scale datasets for medical applications.<\/jats:p>","DOI":"10.1515\/itit-2014-1076","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T12:35:26Z","timestamp":1422621326000},"page":"37-48","source":"Crossref","is-referenced-by-count":0,"title":["Network-based interactive navigation and analysis of large biological datasets"],"prefix":"10.1515","volume":"57","author":[{"given":"Andreas","family":"Gerasch","sequence":"first","affiliation":[{"name":"Dept. for Computer Science, Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"K\u00fcntzer","sequence":"additional","affiliation":[{"name":"Roche Pharmaceutical Research and Early Development, pRED Informatics, Roche Innovation Center Penzberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Niermann","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"St\u00f6ckel","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Saarland University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Dept. for Computer Science, Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kohlbacher","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Peter","family":"Lenhof","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, Saarland University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,1,30]]},"container-title":["it - Information Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/itit-2014-1076\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/itit-2014-1076\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:43:51Z","timestamp":1624448631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/itit-2014-1076\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,30]]},"published-print":{"date-parts":[[2015,2,28]]}},"alternative-id":["10.1515\/itit-2014-1076"],"URL":"https:\/\/doi.org\/10.1515\/itit-2014-1076","relation":{},"ISSN":["1611-2776","2196-7032"],"issn-type":[{"value":"1611-2776","type":"print"},{"value":"2196-7032","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}