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Quantitative investigations of miRNA gene evolution requires the construction of data sets that are consistent in their coverage and include those genomes that are of interest in a given study. Given the size and structure of data, this can be achieved only with the help of a fully automatic pipeline that improves the available seed alignments, extends the set of available sequences by homology search, and reliably identifies true positive homology search results. Here we describe the current progress towards such a system, emphasizing the task of improving and completing the initial seed alignment.<\/jats:p>","DOI":"10.1515\/jib-2016-0013","type":"journal-article","created":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T10:01:56Z","timestamp":1496570516000},"source":"Crossref","is-referenced-by-count":6,"title":["Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution"],"prefix":"10.1515","volume":"14","author":[{"given":"Ali M.","family":"Yazbeck","sequence":"first","affiliation":[{"name":"Bioinformatics Group , Department of Computer Science, and Interdisciplinary Center for Bioinformatics , University Leipzig , H\u00e4rtelstra\u00dfe 16-18 , D-04107 Leipzig , Germany"},{"name":"Lebanese University , Doctoral School for Science and Technology , Rafic Hariri University Campus , Hadath , Lebanon"}]},{"given":"Kifah R.","family":"Tout","sequence":"additional","affiliation":[{"name":"Lebanese University , Doctoral School for Science and Technology , Rafic Hariri University Campus , Hadath , Lebanon"}]},{"given":"Peter F.","family":"Stadler","sequence":"additional","affiliation":[{"name":"Bioinformatics Group , Department of Computer Science, and Interdisciplinary Center for Bioinformatics , University Leipzig , H\u00e4rtelstra\u00dfe 16-18 , D-04107 Leipzig , Germany"},{"name":"German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Competence Center for Scalable Data Services and Solutions, and Leipzig Research Center for Civilization Diseases , University Leipzig , Leipzig , Germany"},{"name":"Max Planck Institute for Mathematics in the Sciences , Inselstra\u00dfe 22 , D-04103 Leipzig , Germany"},{"name":"Fraunhofer Institute for Cell Therapy and Immunology , Perlickstra\u00dfe 1 , D-04103 Leipzig , Germany"},{"name":"Department of Theoretical Chemistry of the University of Vienna , W\u00e4hringerstra\u00dfe 17 , A-1090 Vienna , Austria"}]},{"given":"Jana","family":"Hertel","sequence":"additional","affiliation":[{"name":"Helmholtz Centre for Environmental Research \u2013 UFZ , Young Investigators Group Bioinformatics and Transcriptomics , Permoserstra\u00dfe 15 , D-04318 Leipzig , Germany"}]}],"member":"374","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"2023033120195118063_j_jib-2016-0013_ref_001_w2aab3b7c16b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Cerutti H, Casas-Mollano JA. 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