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Mutations in microRNA seed regions may disrupt the binding of microRNAs to their original target genes and make them bind to new target genes. Here we use a knowledge-based computational method to systematically predict the functional effects of all the possible single nucleotide mutations in human microRNA seed regions. The result provides a comprehensive reference for the functional assessment of the impacts of possible natural and artificial single nucleotide mutations in microRNA seed regions.<\/jats:p>","DOI":"10.1515\/jib-2017-0001","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:03:25Z","timestamp":1495188205000},"source":"Crossref","is-referenced-by-count":17,"title":["Systematic Prediction of the Impacts of Mutations in MicroRNA Seed Sequences"],"prefix":"10.1515","volume":"14","author":[{"given":"Anindya","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering , University of California , San Diego , CA 92093 , USA"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Microbiology , Immunology and Biochemistry , University of Tennessee Health Science Center , Memphis , TN 38163 , USA"},{"name":"Center for Integrative and Translational Genomics , University of Tennessee Health Science Center , Memphis , TN 38163 , USA"}]}],"member":"374","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"2023033120195116285_j_jib-2017-0001_ref_001_w2aab3b7c23b1b6b1ab2b1aAa","doi-asserted-by":"crossref","unstructured":"Siomi H, Siomi MC. 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