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Rice production is also hampered by salinity and the effect of salt is most severe at the seedling and reproductive stages. Salainity tolerance is a quantitative property controlled by multiple genes coding for signaling molecules, ion transporters, metabolic enzymes and transcription regulators. MicroRNAs are key modulators of gene-expression that act at the post-transcriptional level by translation repression or transcript cleavage. They also play an important role in regulating plant\u2019s response to salt-stress. In this work we adopted the approach of comparative and integrated data-mining to understand the miRNA-mediated regulation of salt-stress in rice. We profiled and compared the miRNA regulations using natural varieties and transgenic lines with contrasting behaviors in response to salt-stress. The information obtained from sRNAseq, RNAseq and degradome datasets was integrated to identify the salt-deregulated miRNAs, their targets and the associated metabolic pathways. The analysis revealed the modulation of many biological pathways, which are involved in salt-tolerance and play an important role in plant phenotype and physiology. The end modifications of the miRNAs were also studied in our analysis and isomiRs having a dynamic role in salt-tolerance mechanism were identified.<\/jats:p>","DOI":"10.1515\/jib-2017-0002","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T10:01:17Z","timestamp":1498125677000},"source":"Crossref","is-referenced-by-count":32,"title":["Comparative miRomics of Salt-Tolerant and Salt-Sensitive Rice"],"prefix":"10.1515","volume":"14","author":[{"given":"Kavita","family":"Goswami","sequence":"first","affiliation":[{"name":"Plant RNAi Biology Group, International Center for Genetic Engineering and Biotechnology , Aruna Asaf Ali Marg , New Delhi , India"}]},{"given":"Anita","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Plant RNAi Biology Group, International Center for Genetic Engineering and Biotechnology , Aruna Asaf Ali Marg , New Delhi , India"}]},{"given":"Neeti","family":"Sanan-Mishra","sequence":"additional","affiliation":[{"name":"Plant RNAi Biology Group, International Center for Genetic Engineering and Biotechnology , Aruna Asaf Ali Marg , New Delhi , India"}]}],"member":"374","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"2023033120195120799_j_jib-2017-0002_ref_001_w2aab3b7c41b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Barrera-Figueroa BE, Wu Z, Liu R. 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