{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T08:42:35Z","timestamp":1768120955555,"version":"3.49.0"},"reference-count":66,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Banana peels are well recognized as a source of important bioactive compounds, such as phenolics, carotenoids, biogenic amines, among others. As such, they have recently started to be used for industrial purposes. However, its composition seems to be strongly affected by biotic or abiotic ecological factors. Thus, this study aimed to investigate banana peels chemical composition, not only to get insights on eventual metabolic changes caused by the seasons, in southern Brazil, but also to identify the most relevant metabolites for these processes. To achieve this, a Nuclear magnetic resonance (NMR)-based metabolic profiling strategy was adopted, followed by chemometrics analysis, using the <jats:italic>specmine<\/jats:italic> package for the R environment, and metabolite identification. The results showed that the metabolomic approach adopted allowed identifying a series of primary and secondary metabolites in the aqueous extracts investigated. Besides, over the seasons the metabolic profiles of the banana peels showed to contain biologically active compounds relevant to the skin wound healing process, indicating the biotechnological potential of that raw material.<\/jats:p>","DOI":"10.1515\/jib-2017-0053","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T07:59:31Z","timestamp":1513151971000},"source":"Crossref","is-referenced-by-count":4,"title":["A Chemometrics Approach for Nuclear Magnetic Resonance Data to Characterize the Partial Metabolome Banana Peels from Southern Brazil"],"prefix":"10.1515","volume":"14","author":[{"given":"Sara","family":"Cardoso","sequence":"first","affiliation":[{"name":"CEB-Centre Biological Engineering, School of Engineering, University of Minho, Campus of Gualtar, Braga, Portugal"}]},{"given":"Marcelo","family":"Maraschin","sequence":"additional","affiliation":[{"name":"Plant Morphogenesis and Biochemistry Laboratory, Federal University of Santa Catarina, Florianpolis, SC, Brazil"}]},{"given":"Luiz Augusto Martins","family":"Peruch","sequence":"additional","affiliation":[{"name":"Agricultural Research and Rural Extension Company of Santa Catarina, Crici\u00fama, Brazil"}]},{"given":"Miguel","family":"Rocha","sequence":"additional","affiliation":[{"name":"CEB-Centre Biological Engineering, School of Engineering, University of Minho, Campus of Gualtar,Braga, Portugal"}]},{"given":"Aline","family":"Pereira","sequence":"additional","affiliation":[{"name":"Plant Morphogenesis and Biochemistry Laboratory, Federal University of Santa Catarina, Florianpolis, SC, Brazil"}]}],"member":"374","reference":[{"key":"ref371","first-page":"51","article-title":"Traditional and medicinal uses of banana","volume":"1","year":"2012","journal-title":"J Pharmacogn Phytochem"},{"key":"ref301","first-page":"48","article-title":"Arginine metabolism and wound healing","volume":"1","year":"2008","journal-title":"Wound Healing Southern Africa"},{"key":"ref501","first-page":"95","volume-title":"Biochemistry of fruit ripening","year":"1993"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1007\/s00216-013-6852-y","article-title":"An efficient spectra processing method for metabolite identification from 1H-NMR metabolomics data","volume":"405","year":"2013","journal-title":"Anal Bioanal Chem"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","year":"2005","journal-title":"Mol Aspects Med"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cmpb.2016.01.008","article-title":"An R package for the integrated analysis of metabolomics and spectral data","volume":"129","year":"2016","journal-title":"Comput Methods Programs Biomed"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0925-5214(03)00103-0","article-title":"Relationship between browning and the activities of polyphenoloxidase and phenylalanine ammonia lyase in banana peel during low temperature storage","volume":"30","year":"2003","journal-title":"Postharvest Biol Technol"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.foodchem.2009.08.012","article-title":"Antioxidant activity in banana peel extracts: testing extraction conditions and related bioactive compounds","volume":"119","year":"2010","journal-title":"Food Chem"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/ajcn\/83.6.1265","article-title":"Carotenoids and cardiovascular health","volume":"83","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/jf010830b","article-title":"Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure \u2013 activity relationship","volume":"50","year":"2002","journal-title":"J Agric Food Chem"},{"key":"ref471","volume-title":"A guide to carotenoid analysis in food","year":"2001"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0955-2863(95)00168-9","article-title":"Flavonoids \u2013 chemistry, metabolism, cardioprotective effects, and dietary sources","volume":"7","year":"1996","journal-title":"J Nutr Biochem"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0308-8146(02)00186-3","article-title":"Antioxidant compounds from bananas (Musa Cavendish)","volume":"79","year":"2002","journal-title":"Food Chem"},{"key":"ref381","first-page":"71","article-title":"Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer","volume":"13","year":"2002","journal-title":"Am J Med"},{"key":"ref211","year":"2014","journal-title":"Determina\u00e7\u00e3o do perfil qu\u00edmico e da atividade cicatrizante de extratos de casca de banana cultivar prata an\u00e3 (Musa sp.) e o desenvolvimento de um curativo para pequenas les\u00f5es. PhD thesis"},{"key":"ref251","first-page":"D801","article-title":"HMDB 3.0-The Human Metabolome Database in 2013","volume":"41","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"33549","DOI":"10.1038\/srep33549","article-title":"Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2","volume":"6","year":"2016","journal-title":"Sci Rep"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0031-9422(00)85814-8","article-title":"The sterols and triterpenes of banana peel","volume":"8","year":"1969","journal-title":"Phytochemistry"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cmpb.2016.01.008","article-title":"An R package for the integrated analysis of metabolomics and spectral data","volume":"129","year":"2016","journal-title":"Comput Methods Programs Biomed"},{"key":"ref161","first-page":"95","volume-title":"Biochemistry of fruit ripening","year":"1993"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.jnatprod.5b00315","article-title":"Metabolic profiling and classification of propolis samples from Southern Brazil: an NMR-based platform coupled with machine learning","volume":"79","year":"2016","journal-title":"J Nat Prod"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3177\/jnsv.42.553","article-title":"Carotenoids and their fatty-acid esters in banana peel","volume":"42","year":"1996","journal-title":"Nutr Sci Vitaminol"},{"key":"ref531","first-page":"109","volume-title":"L\u2019am\u00e9lioration des plantes tropicales","year":"2004"},{"key":"ref191","first-page":"109","volume-title":"L\u2019am\u00e9lioration des plantes tropicales","year":"2004"},{"key":"ref641","first-page":"48","article-title":"Arginine metabolism and wound healing","volume":"1","year":"2008","journal-title":"Wound Healing Southern Africa"},{"key":"ref661","volume-title":"Nutrition and wound healing","year":"2007"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11130-008-0097-5","article-title":"Bioactive compounds and health-promoting properties of berry fruits: a review","volume":"63","year":"2008","journal-title":"Plant Foods Hum Nutr"},{"key":"ref631","volume-title":"Handbook of food science, technology and engineering","volume":"Volume 4","year":"2005"},{"key":"ref321","volume-title":"Nutrition and wound healing","year":"2007"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jep.2014.11.008","article-title":"Banana (Musa spp) from peel to pulp: ethnopharmacology, source of bioactive compounds and its relevance for human health","volume":"160","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref441","first-page":"100","article-title":"The role of carotenoids in the prevention of human pathologies","volume":"48","year":"2004","journal-title":"Biomed Pharmacother"},{"key":"ref491","first-page":"162","article-title":"Fluorescence histochemical study on serotonin and catecholamine in some plants","volume":"18","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jep.2014.11.008","article-title":"Banana (Musa spp) from peel to pulp: ethnopharmacology, source of bioactive compounds and its relevance for human health","volume":"160","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref131","volume-title":"A guide to carotenoid analysis in food","year":"2001"},{"key":"ref151","first-page":"162","article-title":"Fluorescence histochemical study on serotonin and catecholamine in some plants","volume":"18","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0925-5214(03)00103-0","article-title":"Relationship between browning and the activities of polyphenoloxidase and phenylalanine ammonia lyase in banana peel during low temperature storage","volume":"30","year":"2003","journal-title":"Postharvest Biol Technol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","year":"2005","journal-title":"Mol Aspects Med"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0308-8146(02)00186-3","article-title":"Antioxidant compounds from bananas (Musa Cavendish)","volume":"79","year":"2002","journal-title":"Food Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11130-008-0097-5","article-title":"Bioactive compounds and health-promoting properties of berry fruits: a review","volume":"63","year":"2008","journal-title":"Plant Foods Hum Nutr"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1749-6632.1993.tb26159.x","article-title":"Absorption and transport of carotenoids","volume":"691","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1749-6632.1993.tb26159.x","article-title":"Absorption and transport of carotenoids","volume":"691","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1007\/s13197-012-0861-2","article-title":"Banana by-products: an under-utilized renewable food biomass with great potential","volume":"51","year":"2014","journal-title":"J Food Sci Technol"},{"key":"ref291","volume-title":"Handbook of food science, technology and engineering","volume":"Volume 4","year":"2005"},{"key":"ref361","year":"1945","journal-title":"As frutas na medicina dom\u00e9stica"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3177\/jnsv.42.553","article-title":"Carotenoids and their fatty-acid esters in banana peel","volume":"42","year":"1996","journal-title":"Nutr Sci Vitaminol"},{"key":"ref551","year":"2014","journal-title":"Determina\u00e7\u00e3o do perfil qu\u00edmico e da atividade cicatrizante de extratos de casca de banana cultivar prata an\u00e3 (Musa sp.) e o desenvolvimento de um curativo para pequenas les\u00f5es. PhD thesis"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0271-5317(88)80121-0","article-title":"Wound healing in pyridoxine deficiency","volume":"8","year":"1988","journal-title":"Nutr Res"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/ajcn\/83.6.1265","article-title":"Carotenoids and cardiovascular health","volume":"83","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0955-2863(95)00168-9","article-title":"Flavonoids \u2013 chemistry, metabolism, cardioprotective effects, and dietary sources","volume":"7","year":"1996","journal-title":"J Nutr Biochem"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1021\/jf9909860","article-title":"High content of dopamine, a strong antioxidant, in cavendish banana","volume":"48","year":"2000","journal-title":"J Agric Food Chem"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"33549","DOI":"10.1038\/srep33549","article-title":"Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2","volume":"6","year":"2016","journal-title":"Sci Rep"},{"key":"ref41","first-page":"71","article-title":"Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer","volume":"13","year":"2002","journal-title":"Am J Med"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1021\/jf9909860","article-title":"High content of dopamine, a strong antioxidant, in cavendish banana","volume":"48","year":"2000","journal-title":"J Agric Food Chem"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0271-5317(88)80121-0","article-title":"Wound healing in pyridoxine deficiency","volume":"8","year":"1988","journal-title":"Nutr Res"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0031-9422(00)85814-8","article-title":"The sterols and triterpenes of banana peel","volume":"8","year":"1969","journal-title":"Phytochemistry"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"9147","DOI":"10.3390\/molecules18089147","article-title":"Synthesis and biological properties of caffeic acid-PNA dimers containing guanine","volume":"18","year":"2013","journal-title":"Molecules"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"9147","DOI":"10.3390\/molecules18089147","article-title":"Synthesis and biological properties of caffeic acid-PNA dimers containing guanine","volume":"18","year":"2013","journal-title":"Molecules"},{"key":"ref591","first-page":"D801","article-title":"HMDB 3.0-The Human Metabolome Database in 2013","volume":"41","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.foodchem.2009.08.012","article-title":"Antioxidant activity in banana peel extracts: testing extraction conditions and related bioactive compounds","volume":"119","year":"2010","journal-title":"Food Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1007\/s13197-012-0861-2","article-title":"Banana by-products: an under-utilized renewable food biomass with great potential","volume":"51","year":"2014","journal-title":"J Food Sci Technol"},{"key":"ref21","year":"1945","journal-title":"As frutas na medicina dom\u00e9stica"},{"key":"ref31","first-page":"51","article-title":"Traditional and medicinal uses of banana","volume":"1","year":"2012","journal-title":"J Pharmacogn Phytochem"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1007\/s00216-013-6852-y","article-title":"An efficient spectra processing method for metabolite identification from 1H-NMR metabolomics data","volume":"405","year":"2013","journal-title":"Anal Bioanal Chem"},{"key":"ref101","first-page":"100","article-title":"The role of carotenoids in the prevention of human pathologies","volume":"48","year":"2004","journal-title":"Biomed Pharmacother"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/jf010830b","article-title":"Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure \u2013 activity relationship","volume":"50","year":"2002","journal-title":"J Agric Food Chem"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.jnatprod.5b00315","article-title":"Metabolic profiling and classification of propolis samples from Southern Brazil: an NMR-based platform coupled with machine learning","volume":"79","year":"2016","journal-title":"J Nat Prod"}],"container-title":["Journal of Integrative Bioinformatics"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jib\/14\/4\/article-20170053.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jib-2017-0053\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:57:41Z","timestamp":1619056661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jib-2017-0053\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,13]]},"references-count":66,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1515\/jib-2017-0053","relation":{},"ISSN":["1613-4516"],"issn-type":[{"value":"1613-4516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,13]]}}}