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To facilitate the discovery of causative genes, various approaches for prioritization of genes according to their relevance for a given disease have been developed. In this article, we explain the gene prioritization problem and provide an overview of computational tools for gene prioritization. Among about a hundred of published gene prioritization tools, we select and briefly describe 14 most up-to-date and user-friendly. Also, we discuss the advantages and disadvantages of existing tools, challenges of their validation, and the directions for future research.<\/jats:p>","DOI":"10.1515\/jib-2018-0069","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T09:02:30Z","timestamp":1567933350000},"source":"Crossref","is-referenced-by-count":36,"title":["A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases"],"prefix":"10.1515","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9424-8052","authenticated-orcid":false,"given":"Olga","family":"Zolotareva","sequence":"first","affiliation":[{"name":"Bielefeld University, Faculty of Technology and Center for Biotechnology, International Research Training Group \u201cComputational Methods for the Analysis of the Diversity and Dynamics of Genomes\u201d and Genome Informatics , Universit\u00e4tsstra\u00dfe 25 , Bielefeld , Germany"}]},{"given":"Maren","family":"Kleine","sequence":"additional","affiliation":[{"name":"Bielefeld University , Faculty of Technology, Bioinformatics\/Medical Informatics Department , Universit\u00e4tsstra\u00dfe 25 , Bielefeld , Germany"}]}],"member":"374","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"2023033120141674490_j_jib-2018-0069_ref_001_w2aab3b7b3b1b6b1ab1b7b1Aa","doi-asserted-by":"crossref","unstructured":"Perez-Iratxeta C, Bork P, Andrade MA. 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