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Our analysis of genomic neighbourhood of <jats:italic>cad<\/jats:italic> and motifs of the encoded polypeptide and its orthologs suggests a close functional association between cAD1 and ApbE protein (Q82Z24), a FMN insertion and trafficking facilitator. The <jats:italic>cad<\/jats:italic> and <jats:italic>apbE<\/jats:italic> orthologs were coupled in the genomes and ApbE-specific motifs for FMN covalent attachment were identified in <jats:italic>cad<\/jats:italic>-encoded protein sequence and its orthologs. These findings suggest a potential role of FMN-based reductase function of the cAD1 lipoprotein precursor in its processing and release of the active sex pheromone peptide. They may lead to a new approach in prevention of antibiotic resistance spread via targeting sex pheromone processing chaperones or by suppression of the FMN availability and covalent binding. This methods can be also applied to a controlled evolution of bacterial pathogenicity in microbial fuel cells, as the findings suggest the crosstalk between bacterial pathogenicity and bacterial electro-activity.<\/jats:p>","DOI":"10.1515\/jib-2019-0016","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T05:58:48Z","timestamp":1563083928000},"source":"Crossref","is-referenced-by-count":1,"title":["Is there a Function for a Sex Pheromone Precursor?"],"prefix":"10.1515","volume":"16","author":[{"given":"O.","family":"Vasieva","sequence":"first","affiliation":[{"name":"University of Liverpool , Crown street , Liverpool , UK"},{"name":"Ingenet ltd , 3d floor, 207 Regent street , London , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-774X","authenticated-orcid":false,"given":"I.","family":"Goryanin","sequence":"additional","affiliation":[{"name":"University of Edinburgh , Edinburgh , UK"},{"name":"Okinawa Institute Science and Technology , Okinawa , Japan"},{"name":"Tianjin Institute of Industrial Biotechnology , Tianjin , China"}]}],"member":"374","published-online":{"date-parts":[[2019,7,13]]},"reference":[{"key":"2023033120141665967_j_jib-2019-0016_ref_001_w2aab3b7b4b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Sporer AJ, Kahl LJ, Price-Whelan A, Dietrich LEP. 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