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The annual event brings together researchers, biocurators and software engineers to present recent results and discuss future work in the area of standards for systems and synthetic biology. The COMBINE initiative coordinates the development of various community standards and formats for computational models in the life sciences. Over the past 10 years, COMBINE has brought together standard communities that have further developed and harmonized their standards for better interoperability of models and data. COMBINE 2019 was co-located with a stakeholder workshop of the European EU-STANDS4PM initiative that aims at harmonized data and model standardization for <jats:italic>in silico<\/jats:italic> models in the field of personalized medicine, as well as with the FAIRDOM PALs meeting to discuss findable, accessible, interoperable and reusable (FAIR) data sharing. This report briefly describes the work discussed in invited and contributed talks as well as during breakout sessions. It also highlights recent advancements in data, model, and annotation standardization efforts. Finally, this report concludes with some challenges and opportunities that this community will face during the next 10 years.<\/jats:p>","DOI":"10.1515\/jib-2020-0005","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:41:19Z","timestamp":1594384879000},"source":"Crossref","is-referenced-by-count":30,"title":["The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE)"],"prefix":"10.1515","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-5563","authenticated-orcid":false,"given":"Dagmar","family":"Waltemath","sequence":"first","affiliation":[{"name":"Medical Informatics , University Medicine Greifswald , Greifswald , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-7084","authenticated-orcid":false,"given":"Martin","family":"Golebiewski","sequence":"additional","affiliation":[{"name":"Heidelberg Institute for Theoretical Studies (HITS) , Heidelberg , 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