{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:27:28Z","timestamp":1759206448848},"reference-count":204,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study aims to investigate the role of viscoelastic interactions between cells and extracellular matrix (ECM) in avascular tumor growth. Computer simulations of glioma multicellular tumor spheroid (MTS) growth are being carried out for various conditions. The calculations are based on a continuous model, which simulates oxygen transport into MTS; transitions between three cell phenotypes, cell transport, conditioned by hydrostatic forces in cell\u2013ECM composite system, cell motility and cell adhesion. Visco-elastic cell aggregation and elastic ECM scaffold represent two compressible constituents of the composite. Cell\u2013ECM interactions form a Transition Layer on the spheroid surface, where mechanical characteristics of tumor undergo rapid transition. This layer facilitates tumor progression to a great extent. The study demonstrates strong effects of ECM stiffness, mechanical deformations of the matrix and cell\u2013cell adhesion on tumor progression. The simulations show in particular that at certain, rather high degrees of matrix stiffness a formation of distant multicellular clusters takes place, while at further increase of ECM stiffness subtumors do not form. The model also illustrates to what extent mere mechanical properties of cell\u2013ECM system may contribute into variations of glioma invasion scenarios.<\/jats:p>","DOI":"10.1515\/jib-2020-0027","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T13:10:08Z","timestamp":1608642608000},"source":"Crossref","is-referenced-by-count":7,"title":["Cell \u2013 extracellular matrix interaction in glioma growth. In silico model"],"prefix":"10.1515","volume":"17","author":[{"given":"Vladimir","family":"Kalinin","sequence":"first","affiliation":[{"name":"R&D Sector, Techno-Modeling Arts Ireland, Unit 8, Cul na Raithe, A91K8KR, Louth, Ireland"}]}],"member":"374","reference":[{"key":"ref931","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-1-4684-4895-5_30","article-title":"Oxygen consumption and oxygen diffusion properties of multicellular spheroids from two different cell lines","volume":"180","year":"1984","journal-title":"Adv Exp Med Biol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1529\/biophysj.108.140624","article-title":"The role of extracellular matrix in glioma invasion: a cellular Potts model approach","volume":"95","year":"2008","journal-title":"Biophys J"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1227\/00006123-199604000-00026","article-title":"Migration of human glioma cells on 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