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MiRNAs are expressed by more than 200 organisms ranging from viruses to higher eukaryotes. Since miRNAs seem to be involved in host\u2013pathogen interactions, many studies attempted to identify whether human miRNAs could target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNAs as an antiviral defence mechanism. In this work, a machine learning based miRNA analysis workflow was developed to predict differential expression patterns of human miRNAs during SARS-CoV-2 infection. In order to obtain the graphical representation of miRNA hairpins, 36 features were defined based on the secondary structures. Moreover, potential targeting interactions between human circRNAs and miRNAs as well as human miRNAs and viral mRNAs were investigated.<\/jats:p>","DOI":"10.1515\/jib-2020-0047","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T21:30:43Z","timestamp":1615930243000},"page":"45-50","source":"Crossref","is-referenced-by-count":24,"title":["Circular RNA\u2013MicroRNA\u2013MRNA interaction predictions in SARS-CoV-2 infection"],"prefix":"10.1515","volume":"18","author":[{"given":"Y\u0131lmaz Mehmet","family":"Demirci","sequence":"first","affiliation":[{"name":"Faculty of Engineering, Engineering Science Department , Abdullah G\u00fcl University , 38080 Kayseri , Turkey"}]},{"given":"M\u00fc\u015ferref Duygu","family":"Sa\u00e7ar Demirci","sequence":"additional","affiliation":[{"name":"Faculty of Life and Natural Sciences, Bioinformatics Department , Abdullah G\u00fcl University , 38080 Kayseri , Turkey"}]}],"member":"374","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"2023033120072478966_j_jib-2020-0047_ref_001_w2aab3b7d133b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Sa\u00e7ar Demirci, MD, Baumbach, J, Allmer, J. 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