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Previously, identification of these interactions was based on sequence-based predicted target binding information. With the advancement in high-throughput omics technologies, miRNA and mRNA expression for the same set of samples are available. This helps develop more efficient and flexible approaches that work by integrating miRNA and mRNA expression profiles with target binding information. Since these integrative approaches of miRNA\u2013mRNA regulatory modules (MRMs) detection is sufficiently able to capture the minute biological details, 26 such algorithms\/methods\/tools for MRMs identification are comprehensively reviewed in this article. The study covers the significant features underlying every method. Therefore, the methods are classified into eight groups based on mathematical approaches to understand their working and suitability for one\u2019s study. An algorithm could be selected based on the available information with the users and the biological question under investigation.<\/jats:p>","DOI":"10.1515\/jib-2020-0048","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:39:33Z","timestamp":1648762773000},"source":"Crossref","is-referenced-by-count":19,"title":["A review on methods for predicting miRNA\u2013mRNA regulatory modules"],"prefix":"10.1515","volume":"19","author":[{"given":"Madhumita","family":"Madhumita","sequence":"first","affiliation":[{"name":"Department of Bioscience and Bioengineering , Indian Institute of Technology , Jodhpur 342037 , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushmita","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Bioengineering , Indian Institute of Technology , Jodhpur 342037 , Rajasthan , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"2023033120301376344_j_jib-2020-0048_ref_001","doi-asserted-by":"crossref","unstructured":"Calin, GA, Ferracin, M, Cimmino, A, Leva, GD, Shimizu, M, Wojcik, SE, et al.. 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