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The 2021 special issue presents four updates of standards: Synthetic Biology Open Language Visual Version 2.3, Synthetic Biology Open Language Visual Version 3.0, Simulation Experiment Description Markup Language Level 1 Version 4, and OMEX Metadata specification Version 1.2. This document can also be consulted to identify the latest specifications of all COMBINE standards.<\/jats:p>","DOI":"10.1515\/jib-2021-0026","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T04:45:58Z","timestamp":1634877958000},"source":"Crossref","is-referenced-by-count":3,"title":["Specifications of standards in systems and synthetic biology: status and developments in 2021"],"prefix":"10.1515","volume":"18","author":[{"given":"Falk","family":"Schreiber","sequence":"first","affiliation":[{"name":"Department of Computer and Information Science , University of Konstanz , Konstanz , Germany"},{"name":"Faculty of Information Technology , Monash University , Clayton , Australia"}]},{"given":"Padraig","family":"Gleeson","sequence":"additional","affiliation":[{"name":"University College London , London , UK"}]},{"given":"Martin","family":"Golebiewski","sequence":"additional","affiliation":[{"name":"Heidelberg Institute for Theoretical Studies (HITS) , Heidelberg , Germany"}]},{"given":"Thomas E.","family":"Gorochowski","sequence":"additional","affiliation":[{"name":"School of Biological Sciences , University of Bristol , Bristol , UK"}]},{"given":"Michael","family":"Hucka","sequence":"additional","affiliation":[{"name":"California Institute of Technology , Pasadena , USA"}]},{"given":"Sarah M.","family":"Keating","sequence":"additional","affiliation":[{"name":"University College London , London , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-179X","authenticated-orcid":false,"given":"Matthias","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute for Theoretical Biology, Humboldt-University Berlin , Berlin , Germany"}]},{"given":"Chris J.","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Electrical, Computer, and Energy Eng. , University of Colorado Boulder , Boulder , USA"}]},{"given":"David P.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute, University of Auckland , Auckland , New Zealand"}]},{"given":"Bj\u00f6rn","family":"Sommer","sequence":"additional","affiliation":[{"name":"Royal College of Arts , London , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-5563","authenticated-orcid":false,"given":"Dagmar","family":"Waltemath","sequence":"additional","affiliation":[{"name":"University Medicine Greifswald , Rostock , Germany"}]}],"member":"374","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"2023033120082513360_j_jib-2021-0026_ref_001","doi-asserted-by":"crossref","unstructured":"Waltemath, D, Golebiewski, M, Blinov, ML, Gleeson, P, Hermjakob, H, Hucka, M, et al.. 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