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Progression is one of the important features of breast cancer which makes it a life-threatening cancer. MicroRNAs are small RNA molecules that have pivotal roles in the regulation of gene expression and they control different properties in breast cancer such as progression. Recently, systems biology offers novel approaches to study complicated biological systems like miRNAs to find their regulatory roles. One of these approaches is analysis of weighted co-expression network in which genes with similar expression patterns are considered as a single module. Because the genes in one module have similar expression, it is rational to think the same regulatory elements such as miRNAs control their expression. Herein, we use WGCNA to find important modules related to breast cancer progression and use hypergeometric test to perform miRNA target enrichment analysis and find important miRNAs. Also, we use negative correlation between miRNA expression and modules as the second filter to ensure choosing the right candidate miRNAs regarding to important modules. We found hsa-mir-23b, hsa-let-7b and hsa-mir-30a are important miRNAs in breast cancer and also investigated their roles in breast cancer progression.<\/jats:p>","DOI":"10.1515\/jib-2022-0036","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:20:31Z","timestamp":1735017631000},"source":"Crossref","is-referenced-by-count":2,"title":["MiRNA target enrichment analysis of co-expression network modules reveals important miRNAs and their roles in breast cancer progression"],"prefix":"10.1515","volume":"21","author":[{"given":"Mohammad Javad","family":"Bazyari","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine , 37552 Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-7837","authenticated-orcid":false,"given":"Seyed Hamid","family":"Aghaee-Bakhtiari","sequence":"additional","affiliation":[{"name":"Bioinformatics Research Center ,Basic Sciences Research Institute, 37552 Mashhad University of Medical Sciences , Mashhad , Iran"},{"name":"Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine , 37552 Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"2025010310215293313_j_jib-2022-0036_ref_001","doi-asserted-by":"crossref","unstructured":"Sung, H, Ferlay, J, Siegel, RL, Laversanne, M, Soerjomataram, I, Jemal, A, et al.. 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