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These simulations increasingly require extensive collaboration among modelers, experimentalists, and engineers. The Minimum Information About a Simulation Experiment (MIASE) guidelines outline the information needed to share simulation experiments. SED-ML is a computer-readable format for the information outlined by MIASE, created as a community project and supported by many investigators and software tools. Level 1 Version 5 of SED-ML expands the ability of modelers to define simulations in SED-ML using the Kinetic Simulation Algorithm Onotoloy (KiSAO). While it was possible in Version 4 to define a simulation entirely using KiSAO, Version 5 now allows users to define tasks, model changes, ranges, and outputs using the ontology as well. SED-ML is supported by a growing ecosystem of investigators, model languages, and software tools, including various languages for constraint-based, kinetic, qualitative, rule-based, and spatial models, and many simulation tools, visual editors, model repositories, and validators. Additional information about SED-ML is available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/sed-ml.org\/\">https:\/\/sed-ml.org\/<\/jats:ext-link>.<\/jats:p>","DOI":"10.1515\/jib-2024-0008","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T08:50:27Z","timestamp":1712998227000},"source":"Crossref","is-referenced-by-count":5,"title":["The simulation experiment description markup language (SED-ML): language specification for level 1 version 5"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7002-6386","authenticated-orcid":false,"given":"Lucian P.","family":"Smith","sequence":"first","affiliation":[{"name":"7284 University of Washington , Seattle , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-4702","authenticated-orcid":false,"given":"Frank T.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"BioQUANT\/COS , 132140 Heidelberg University , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-5888","authenticated-orcid":false,"given":"Alan","family":"Garny","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute , 428614 The University of Auckland , Auckland , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-1906","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Helikar","sequence":"additional","affiliation":[{"name":"University of Nebraska , Lincoln , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2605-5080","authenticated-orcid":false,"given":"Jonathan","family":"Karr","sequence":"additional","affiliation":[{"name":"5925 Icahn School of Medicine at Mount Sinai , New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-9779","authenticated-orcid":false,"given":"David","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Auckland Bioengineering Institute , 428614 The University of Auckland , Auckland , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-6817","authenticated-orcid":false,"given":"Herbert","family":"Sauro","sequence":"additional","affiliation":[{"name":"7284 University of Washington , Seattle , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-5563","authenticated-orcid":false,"given":"Dagmar","family":"Waltemath","sequence":"additional","affiliation":[{"name":"University of Greifswald , Greifswald , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-179X","authenticated-orcid":false,"given":"Matthias","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"9373 Humboldt University , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,4,15]]},"container-title":["Journal of Integrative Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jib-2024-0008\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jib-2024-0008\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T23:34:02Z","timestamp":1732750442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jib-2024-0008\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,4,15]]},"published-print":{"date-parts":[[2024,7,31]]}},"alternative-id":["10.1515\/jib-2024-0008"],"URL":"https:\/\/doi.org\/10.1515\/jib-2024-0008","relation":{},"ISSN":["1613-4516"],"issn-type":[{"value":"1613-4516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"article-number":"20240008"}}