{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:13:20Z","timestamp":1773432800108,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:00:00Z","timestamp":1432339200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>(1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2- thiol (1) with ethylbromobutyrate, followed by addition of hydrazine hydrate. Treatment of acid hydrazide 3 with carbon disulfide in an ethanolic potassium hydroxide solution gave the intermediate potassium dithiocarbazinate salt, which was cyclized to 4-amino-5-[(1,4,5-triphenylimidazol- -2-yl)thiopropyl]-2H-1,2,4-triazole-3-thione (4) in the presence of hydrazine hydrate. Condensation of compound 3 with alkyl\/arylisothiocyanate afforded the corresponding 1-[4-(1,4,5-triphenylimidazol-2-ylthio)butanoyl]-4-alkyl\/arylthiosemicarbazides (5-7), which upon refluxing with sodium hydroxide, yielded the corresponding 1,2,4-triazole - -3-thiols 8-10. Under acidic conditions, compounds 4-6 were converted to aminothiadiazoles 11-13. Moreover, the series of Schiff bases 14-18 were synthesized from the condensation of compound 3 with different aromatic aldehydes. The newly synthesized compounds were characterized by IR, <jats:sup>1<\/jats:sup>H NMR, <jats:sup>13<\/jats:sup>C NMR and mass spectral analyses. They were also preliminarily screened for their antimicrobial activity.<\/jats:p>","DOI":"10.1515\/acph-2015-0011","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T14:04:06Z","timestamp":1432649046000},"page":"117-132","source":"Crossref","is-referenced-by-count":27,"title":["Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents"],"prefix":"10.1515","volume":"65","author":[{"given":"Mohamed Reda","family":"Aouad","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Taibah University Al-Madinah Al-Munawarah P.O. Box 30002, Saudi Arabia"},{"name":"Department of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf Laboratoire de Chimie and Electrochimie des Complexes M\u00e9talliques (LCECM) USTO-MB, P.O. Box 1505 Oran El M`nouar, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouslim","family":"Messali","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Taibah University Al-Madinah Al-Munawarah P.O. Box 30002, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadjet","family":"Rezki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Taibah University Al-Madinah Al-Munawarah P.O. Box 30002, Saudi Arabia 2 Department of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf Laboratoire de Chimie and Electrochimie des Complexes M\u00e9talliques (LCECM) USTO-MB, P.O. Box 1505 Oran El M`nouar, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeeb Al-Sheikh","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences, Taibah University Al-Madinah Al-Munawarah P.O. Box 30002, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Lesimple","sequence":"additional","affiliation":[{"name":"King Abdullah University of Science and Technology (KAUST) Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,5,23]]},"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/acph\/65\/2\/article-p117.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/acph-2015-0011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T02:54:10Z","timestamp":1617850450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/acph-2015-0011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,23]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,5,23]]},"published-print":{"date-parts":[[2015,6,1]]}},"alternative-id":["10.1515\/acph-2015-0011"],"URL":"https:\/\/doi.org\/10.1515\/acph-2015-0011","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,23]]}}}