{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:05:09Z","timestamp":1772996709244,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T00:00:00Z","timestamp":1464393600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A pharmacokinetic comparison and conformational stability study of <jats:italic>S<\/jats:italic>-oxiracetam (<jats:italic>S<\/jats:italic>-ORT) and <jats:italic>R<\/jats:italic>-oxiracetam (<jats:italic>R<\/jats:italic>-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS\/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of <jats:italic>S<\/jats:italic>-ORT were significantly higher than <jats:italic>R<\/jats:italic>-ORT 1.5 and 2 h after administration; the <jats:italic>AUC<\/jats:italic>\n                  <jats:sub>0-\u221e<\/jats:sub> of <jats:italic>S<\/jats:italic>-ORT after oral administration tended to be higher than that of <jats:italic>R<\/jats:italic>-ORT, which showed that the different effects between <jats:italic>S<\/jats:italic>-ORT and <jats:italic>R<\/jats:italic>-ORT may be partly associated with their distinctive absorption at least.<\/jats:p>","DOI":"10.1515\/acph-2016-0013","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T10:16:19Z","timestamp":1465467379000},"page":"279-287","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetic comparisons of <i>S<\/i>-oxiracetam and <i>R<\/i>-oxiracetam in beagle dogs"],"prefix":"10.1515","volume":"66","author":[{"given":"Wusan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Yijishan Hospital, Wannan Medical College, Wuhu 241002, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitang","family":"Xie","sequence":"additional","affiliation":[{"name":"Yijishan Hospital, Wannan Medical College, Wuhu 241002, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,5,28]]},"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/acph\/66\/2\/article-p279.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/acph-2016-0013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T15:57:38Z","timestamp":1617724658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/acph-2016-0013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,5,28]]},"published-print":{"date-parts":[[2016,6,1]]}},"alternative-id":["10.1515\/acph-2016-0013"],"URL":"https:\/\/doi.org\/10.1515\/acph-2016-0013","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,28]]}}}