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This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.<\/jats:p>","DOI":"10.1515\/acph-2017-0020","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T10:01:10Z","timestamp":1496829670000},"page":"149-168","source":"Crossref","is-referenced-by-count":54,"title":["Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system"],"prefix":"10.1515","volume":"67","author":[{"given":"Pijush Kumar","family":"Paul","sequence":"first","affiliation":[{"name":"Molecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hatyai, Songkhla , 90112, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alongkot","family":"Treetong","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park Phahonyothin Road Pathum Thani 12120, Pathum Thani , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roongnapa","family":"Suedee","sequence":"additional","affiliation":[{"name":"Molecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hatyai, Songkhla , 90112, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"2021040815335203949_j_acph-2017-0020_ref_001_w2aab2b8b2b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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