{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:08:09Z","timestamp":1772802489856,"version":"3.50.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol\/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for &gt; 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.<\/jats:p>","DOI":"10.1515\/acph-2017-0037","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T22:16:07Z","timestamp":1516140967000},"page":"479-494","source":"Crossref","is-referenced-by-count":12,"title":["Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury"],"prefix":"10.1515","volume":"67","author":[{"given":"Joo-Il","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul , 02447, Korea Republic of"},{"name":"Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of Korea"},{"name":"Interdisciplinary Program in Agricultural Biotechnology College of Agriculture and Life Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul , 08826 Korea Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhong-Jae","family":"Lim","sequence":"additional","affiliation":[{"name":"Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se-Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Su","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul , 02447, Korea Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Science College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul , 02447, Korea Republic of"},{"name":"Department of Oriental Pharmaceutical Sciences College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul , 02447, Korea Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Pyo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Science College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea 5 Department of Oriental Pharmaceutical Sciences College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul , 02447, Korea Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kyoung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu Seoul , 02447, Korea Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Tae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul , 02447, Korea Republic of"},{"name":"Department of Life and Nanopharmaceutical Science College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul , 02447, Korea Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"2021040812050186335_j_acph-2017-0037_ref_001_w2aab2b8b8b1b7b1ab1ab1Aa","unstructured":"1. A. F. Syam, M. Sadikin, S. I. Wanandi and A. A. Rani, Molecular mechanism on healing process of peptic ulcer, Acta Med. Indones. 41 (2009) 95-98."},{"key":"2021040812050186335_j_acph-2017-0037_ref_002_w2aab2b8b8b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. J. H. Park, K. J. Jang, C. H. Kim, Y. H. Lee, S. J. Lee, B. H. Kim and H. M. Yoon, Ganoderma lucidum pharmacopuncture for the treatment of acute gastric ulcers in rats, J. Pharmacopuncture 17 (2014) 40-49; http:\/\/doi.org\/10.3831\/KPI.2014.17.025","DOI":"10.3831\/KPI.2014.17.025"},{"key":"2021040812050186335_j_acph-2017-0037_ref_003_w2aab2b8b8b1b7b1ab1ab3Aa","unstructured":"3. A. A. Gohar and A. A. Zaki, Assessment of some herbal drugs for prophylaxis of peptic ulcer, Iran J. Pharm. Res. 13 (2014) 1081-1086."},{"key":"2021040812050186335_j_acph-2017-0037_ref_004_w2aab2b8b8b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. V. Lakshmi, N. Singh, S. Shrivastva, S. K. Mishra, P. Dharmani, V. Mishra and G. Palit, Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats, Phytomedicine 17 (2010) 569-574; http:\/\/doi.org\/10.1016\/j.phymed.2009.10.016","DOI":"10.1016\/j.phymed.2009.10.016"},{"key":"2021040812050186335_j_acph-2017-0037_ref_005_w2aab2b8b8b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. S. S. Davis, Formulation strategies for absorption windows, Drug Discov. Today 10 (2005) 249-257; http:\/\/doi.org\/10.1016\/S1359-6446(04)03351-3","DOI":"10.1016\/S1359-6446(04)03351-3"},{"key":"2021040812050186335_j_acph-2017-0037_ref_006_w2aab2b8b8b1b7b1ab1ab6Aa","doi-asserted-by":"crossref","unstructured":"6. A. Streubel, J. Siepmann and R. Bodmeier, Gastroretentive drug delivery systems, Expert. Opin. Drug Deliv. 3 (2006) 217-233; http:\/\/doi.org\/10.1517\/17425247.3.2.217","DOI":"10.1517\/17425247.3.2.217"},{"key":"2021040812050186335_j_acph-2017-0037_ref_007_w2aab2b8b8b1b7b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. P. L. Bardonnet, V. Faivre, W. J. Pugh, J. C. Piffaretti and F. Falson, Gastroretentive dosage forms: overview and special case of Helicobacter pylori, J. Control. Release 111 ( 2006) 1 -18; h ttp:\/\/doi. org\/10.1016\/j.jconrel.2005.10.031","DOI":"10.1016\/j.jconrel.2005.10.031"},{"key":"2021040812050186335_j_acph-2017-0037_ref_008_w2aab2b8b8b1b7b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. H. T. Trinh, I. A. Lee, Y. J. Hyun and D. H. Kim, Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and alpha-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-kappaB activation, Planta Med. 77 (2011) 1996-2002; http:\/\/doi.org\/10.1055\/s-0031-1280094","DOI":"10.1055\/s-0031-1280094"},{"key":"2021040812050186335_j_acph-2017-0037_ref_009_w2aab2b8b8b1b7b1ab1ab9Aa","doi-asserted-by":"crossref","unstructured":"9. E. J. Choi, H. M. Oh, B. R. Na, T. P. Ramesh, H. J. Lee, C. S. Choi, S. C. Choi, T. Y. Oh, S. J. Choi, J. R. Chae, S. W. Kim and C. D. Jun, Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress, Pharm. Res. 25 (2008) 1355- 1364; http:\/\/doi.org\/10.1007\/s11095-008-9531-5","DOI":"10.1007\/s11095-008-9531-5"},{"key":"2021040812050186335_j_acph-2017-0037_ref_010_w2aab2b8b8b1b7b1ab1ac10Aa","doi-asserted-by":"crossref","unstructured":"10. S. Lee, M. Lee and S. H. Kim, Eupatilin inhibits H(2)O(2)-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB, Food Chem. Toxicol. 46 (2008) 2865-2870; http:\/\/doi.org\/10.1016\/j.fct.2008.05.026","DOI":"10.1016\/j.fct.2008.05.026"},{"key":"2021040812050186335_j_acph-2017-0037_ref_011_w2aab2b8b8b1b7b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. K. Huh, T. H. Kwon, U. S. Shin, W. B. Kim, B. O. Ahn, T. Y. Oh and J. A. Kim, Inhibitory effects of DA-9601 on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats, J. Ethnopharmacol. 88 (2003) 269-273; http:\/\/doi.org\/S0378874103002356","DOI":"10.1016\/S0378-8741(03)00235-6"},{"key":"2021040812050186335_j_acph-2017-0037_ref_012_w2aab2b8b8b1b7b1ab1ac12Aa","doi-asserted-by":"crossref","unstructured":"12. T. Y. Oh, J. S. Lee, B. O. Ahn, H. Cho, W. B. Kim, Y. B. Kim, Y. J. Surh, S. W. Cho, K. M. Lee and K. B. Hahm, Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats, Gut 49 (2001) 364-371; http:\/\/doi.org\/10.1136\/gut.49.3.364","DOI":"10.1136\/gut.49.3.364"},{"key":"2021040812050186335_j_acph-2017-0037_ref_013_w2aab2b8b8b1b7b1ab1ac13Aa","doi-asserted-by":"crossref","unstructured":"13. Y. D. Kim, S. C. Choi, T. Y. Oh, J. S. Chun and C. D. Jun, Eupatilin inhibits T-cell activation by modulation of intracellular calcium flux and NF-kappaB and NF-AT activity, J. Cell Biochem. 108 (2009) 225-236; http:\/\/doi.org\/10.1002\/jcb.22244","DOI":"10.1002\/jcb.22244"},{"key":"2021040812050186335_j_acph-2017-0037_ref_014_w2aab2b8b8b1b7b1ab1ac14Aa","doi-asserted-by":"crossref","unstructured":"14. J. M. Park, Y. M. Han, J. S. Lee, K. H. Ko, S. P. Hong, E. H. Kim and K. B. Hahm, Nrf2-mediated mucoprotective and anti-inflammatory actions of Artemisia extracts led to attenuate stress related mucosal damages, J. Clin. Biochem. Nutr. 56 (2015) 132-142; http:\/\/doi.org\/10.3164\/jcbn.14-76","DOI":"10.3164\/jcbn.14-76"},{"key":"2021040812050186335_j_acph-2017-0037_ref_015_w2aab2b8b8b1b7b1ab1ac15Aa","doi-asserted-by":"crossref","unstructured":"15. K. S. Chung, H. E. Choi, J. S. Shin, E. J. Cho, Y. W. Cho, J. H. Choi, N. I. Baek and K. T. Lee, Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-kappaB inactivation on colitis-associated colon tumorigenesis in mice, Food Chem. Toxicol. 75 (2015) 14-23; http:\/\/doi.org\/1016\/j.fct.2014.11.007","DOI":"10.1016\/j.fct.2014.11.007"},{"key":"2021040812050186335_j_acph-2017-0037_ref_016_w2aab2b8b8b1b7b1ab1ac16Aa","doi-asserted-by":"crossref","unstructured":"16. T. H. Kim, S. J. Lee, H. K. Rim, J. S. Shin, J. Y. Jung, J. S. Heo, J. B. Kim, M. S. Lee and K. T. Lee, In vitro and in vivo immunostimulatory effects of hot water extracts from the leaves of Artemisia princeps Pampanini cv. Sajabal, J. Ethnopharmacol. 149 (2013) 254-262; http:\/\/doi.org\/10.1016\/j.jep.2013.06.030","DOI":"10.1016\/j.jep.2013.06.030"},{"key":"2021040812050186335_j_acph-2017-0037_ref_017_w2aab2b8b8b1b7b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. S. Shanmugam, Granulation techniques and technologies: recent progresses, Bioimpacts 5 (2015) 55-63; http:\/\/doi.org\/10.15171\/bi.2015.04","DOI":"10.15171\/bi.2015.04"},{"key":"2021040812050186335_j_acph-2017-0037_ref_018_w2aab2b8b8b1b7b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. A. Robert, J. E. Nezamis, C. Lancaster and A. J. Hanchar, Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury, Gastroenterology 77 (1979) 433-443.","DOI":"10.1016\/0016-5085(79)90002-7"},{"key":"2021040812050186335_j_acph-2017-0037_ref_019_w2aab2b8b8b1b7b1ab1ac19Aa","doi-asserted-by":"crossref","unstructured":"19. N. Yamamoto, M. Ueda, K. Kawabata, T. Sato, K. Kawasaki, T. Hashimoto and H. Ashida, Artemisia princeps extract promoted glucose uptake in cultured L6 muscle cells via glucose transporter 4 translocation, Biosci. Biotechnol. Biochem. 74 (2010) 2036-2042; http:\/\/doi.org\/10.1271\/bbb.100305","DOI":"10.1271\/bbb.100305"},{"key":"2021040812050186335_j_acph-2017-0037_ref_020_w2aab2b8b8b1b7b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. S. W. Min, N. J. Kim, N. I. Baek and D. H. Kim, Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice, J. Ethnopharmacol. 125 (2009) 497-500; http:\/\/doi.org\/10.1016\/j.jep.2009.06.001","DOI":"10.1016\/j.jep.2009.06.001"},{"key":"2021040812050186335_j_acph-2017-0037_ref_021_w2aab2b8b8b1b7b1ab1ac21Aa","doi-asserted-by":"crossref","unstructured":"21. J. K. Ko, C. H. Cho and S. K. Lam, Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis, World J. Gastroenterol. 10 (2004) 2503-2508; http:\/\/doi.org\/10.3748\/wjg.v10.i17.2503","DOI":"10.3748\/wjg.v10.i17.2503"},{"key":"2021040812050186335_j_acph-2017-0037_ref_022_w2aab2b8b8b1b7b1ab1ac22Aa","doi-asserted-by":"crossref","unstructured":"22. Y. A. Sohn, S. A. Hwang, S. Y. Lee, I. Y. Hwang, S. W. Kim, S. Y. Kim, A. Moon, Y. S. Lee, Y. H. Kim, K. J. Kang and C. S. Jeong, Protective effect of liriodendrin isolated from Kalopanax pictus against gastric injury, Biomol. Ther. (Seoul) 23 (2015) 53-59; http:\/\/doi.org\/10.4062\/biomolther.2014.103","DOI":"10.4062\/biomolther.2014.103"},{"key":"2021040812050186335_j_acph-2017-0037_ref_023_w2aab2b8b8b1b7b1ab1ac23Aa","doi-asserted-by":"crossref","unstructured":"23. I. Szelenyi and K. Brune, Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats, Dig. Dis. Sci. 33 (1988) 865-871.","DOI":"10.1007\/BF01550977"},{"key":"2021040812050186335_j_acph-2017-0037_ref_024_w2aab2b8b8b1b7b1ab1ac24Aa","doi-asserted-by":"crossref","unstructured":"24. H. Matsui, O. Shimokawa, T. Kaneko, Y. Nagano, K. Rai and I. Hyodo, The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine, J. Clin. Biochem. Nutr. 48 (2011) 107-111; http:\/\/doi.org\/10.3164\/jcbn.10-79","DOI":"10.3164\/jcbn.10-79"},{"key":"2021040812050186335_j_acph-2017-0037_ref_025_w2aab2b8b8b1b7b1ab1ac25Aa","doi-asserted-by":"crossref","unstructured":"25. T. Urushidani, S. Okabe, K. Takeuchi and K. Takagi, Effects of various amino acids on indomethacin- induced gastric ulcers in rats, Jpn. J. Pharmacol. 27 (1977) 316-319.","DOI":"10.1254\/jjp.27.316"},{"key":"2021040812050186335_j_acph-2017-0037_ref_026_w2aab2b8b8b1b7b1ab1ac26Aa","doi-asserted-by":"crossref","unstructured":"26. M. B. Adinortey, C. Ansah, I. Galyuon and A. Nyarko, In vivo models used for evaluation of potential antigastroduodenal ulcer agents, Ulcers 2013 (2013) 1-12; http:\/\/doi.org\/dx.doi.org\/10.1155\/2013\/796405","DOI":"10.1155\/2013\/796405"},{"key":"2021040812050186335_j_acph-2017-0037_ref_027_w2aab2b8b8b1b7b1ab1ac27Aa","doi-asserted-by":"crossref","unstructured":"27. S. W. Jang, J. W. Lee, S. H. Park, J. H. Kim, M. Yoo, D. H. Na and K. C. Lee, Gastroretentive drug delivery system of DA-6034, a new flavonoid derivative, for the treatment of gastritis, Int. J. Pharm. 356 (2008) 88-94; http:\/\/doi.org\/0.1016\/j.ijpharm.2007.12.042","DOI":"10.1016\/j.ijpharm.2007.12.042"},{"key":"2021040812050186335_j_acph-2017-0037_ref_028_w2aab2b8b8b1b7b1ab1ac28Aa","unstructured":"28. S. H. Shaha, J. K. Patel, K. Pundarikakshudu and N. V. Patel, An overview of a gastro-retentive floating drug delivery system, Asian J. Pharm. Sci. 4 (2009) 65-80."},{"key":"2021040812050186335_j_acph-2017-0037_ref_029_w2aab2b8b8b1b7b1ab1ac29Aa","unstructured":"29. H. Rathod, V. Patel and M. Modasia, Floating drug delivery system: innovative approach of gastroretention, Int. J. Pharm. Sci. Rev. Res. 4 (2010) 183-192."},{"key":"2021040812050186335_j_acph-2017-0037_ref_030_w2aab2b8b8b1b7b1ab1ac30Aa","unstructured":"30. A. E. Yassin, F. Alkhaled, S. al-Suwayeh and S. Elkheshen, Intra-gastric performance and bioavailability study of a new per-oral bioadhesive Verapamil HCl matrix tablet in dogs, Boll. Chim. Farm. 142 (2003) 285-289."}],"container-title":["Acta Pharmaceutica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/acph\/67\/4\/article-p479.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/acph-2017-0037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T13:59:16Z","timestamp":1617976756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/acph-2017-0037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,20]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,1,11]]},"published-print":{"date-parts":[[2017,12,20]]}},"alternative-id":["10.1515\/acph-2017-0037"],"URL":"https:\/\/doi.org\/10.1515\/acph-2017-0037","relation":{},"ISSN":["1846-9558"],"issn-type":[{"value":"1846-9558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,20]]}}}