{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:54:54Z","timestamp":1753887294478,"version":"3.41.2"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Fabry disease is a hereditary disease caused by a mutation in the <jats:italic>\u03b1<\/jats:italic>-galactosidase A (GLA) gene resulting in the accumulation of glycosphingolipids in different organs. Timely diagnosis is crucial for the early initiation of treatment to avoid organic dysfunction secondary to lipid accumulation. In view of the above, a number of studies have been performed to assess the role of mulberry bodies as a new diagnostic tool. In this study, we report a case demonstrating the utility of this test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We report the case of a woman of advanced age without a history of chronic disease with symptoms consistent with urinary tract infection (dysuria, pelvic pain, and frequent urination). Based on laboratory test results, a diagnosis of anemia with concomitant chronic kidney disease was established. Urine test revealed microhematuria, proteinuria, urine sediment, and the presence of lipid particles consistent with mulberry bodies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The identification of mulberry bodies and cells in urine sediment is an easy-to-use tool potentially useful in diagnosing Fabry disease, which may contribute to initiate enzyme replacement therapy in a timely manner and reduce systemic deterioration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/almed-2020-0028","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T08:57:29Z","timestamp":1591088249000},"source":"Crossref","is-referenced-by-count":0,"title":["Mulberry bodies in the urine sediment of a patient with chronic kidney disease"],"prefix":"10.1515","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-0715","authenticated-orcid":false,"given":"Carlos","family":"Mart\u00ednez-Figueroa","sequence":"first","affiliation":[{"name":"Emergency Department , Clinical Laboratory , Cl\u00ednica Hospital ISSSTE , Heroico Colegio Militar 3, Centro, 40000 Iguala de la Independencia , Guerrero , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-2297","authenticated-orcid":false,"given":"Karen","family":"Cort\u00e9s-Sarabia","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Molecular Diagnosis , Faculty of Biochemistry , UAGro , Chilpancingo , Guerrero , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-1375","authenticated-orcid":false,"given":"Hilda Guadalupe","family":"Catal\u00e1n-N\u00e1jera","sequence":"additional","affiliation":[{"name":"Emergency Department , Clinical Laboratory , Cl\u00ednica Hospital ISSSTE , Iguala , Guerrero , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-3003","authenticated-orcid":false,"given":"Micaela","family":"Mart\u00ednez-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Emergency Department , Clinical Laboratory , Cl\u00ednica Hospital ISSSTE , Iguala , Guerrero , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"2023062110014636358_j_almed-2020-0028_ref_001","doi-asserted-by":"crossref","unstructured":"Ortiz A, Sanchez-Ni\u00f1o MD. Diagnosis and treatment of Fabry disease. Med Cl\u00ednica 2017;148:132\u20138. https:\/\/doi.org\/10.1016\/j.medcle.2017.02.009.","DOI":"10.1016\/j.medcle.2017.02.009"},{"key":"2023062110014636358_j_almed-2020-0028_ref_002","doi-asserted-by":"crossref","unstructured":"El-Abassi R, Singhal D, England JD. Fabry's disease. J Neurol Sci [Internet] 2014;344:5\u201319. https:\/\/doi.org\/10.1016\/j.jns.2014.06.029.","DOI":"10.1016\/j.jns.2014.06.029"},{"key":"2023062110014636358_j_almed-2020-0028_ref_003","doi-asserted-by":"crossref","unstructured":"Mehta A, Ricci R, Widmer U, Dehout F, Garcia de Lorenzo A, Kampmann C, et al. Fabry disease defined: baseline clinical manifestations of 366 patients in the Fabry Outcome Survey. Eur J Clin Invest 2004;34:236\u201342. https:\/\/doi.org\/10.1111\/j.1365-2362.2004.01309.x.","DOI":"10.1111\/j.1365-2362.2004.01309.x"},{"key":"2023062110014636358_j_almed-2020-0028_ref_004","doi-asserted-by":"crossref","unstructured":"Vujkovac B. Fabry disease: diagnostic methods in nephrology practice. Clin Nephrol 2017;88:44\u20137. https:\/\/doi.org\/10.5414\/cnp88fx28.","DOI":"10.5414\/CNP88FX28"},{"key":"2023062110014636358_j_almed-2020-0028_ref_005","doi-asserted-by":"crossref","unstructured":"CKD Work Group. KDIGO 2012 clinical practice guideline for the\u00a0evaluation and management of chronic kidney disease. Kidney\u00a0Int Suppl 2013;3:1\u2013150. https:\/\/doi.org\/10.1038\/kisup.2012.76.","DOI":"10.1038\/kisup.2012.76"},{"key":"2023062110014636358_j_almed-2020-0028_ref_006","doi-asserted-by":"crossref","unstructured":"Honda T, Komatsu E, Furuse S, Mise N. Fabry disease diagnosed based on the detection of urinary mulberry bodies. Intern Med 2016;55:2903\u20132903. https:\/\/doi.org\/10.2169\/internalmedicine.55.7084.","DOI":"10.2169\/internalmedicine.55.7084"},{"key":"2023062110014636358_j_almed-2020-0028_ref_007","doi-asserted-by":"crossref","unstructured":"Selvarajah M, Nicholls K, Hewitson TD, Becker GJ. Targeted urine microscopy in Anderson-Fabry disease: a cheap, sensitive and specific diagnostic technique. Nephrol Dial Transplant 2011;26:3195\u2013202. https:\/\/doi.org\/10.1093\/ndt\/gfr084.","DOI":"10.1093\/ndt\/gfr084"},{"key":"2023062110014636358_j_almed-2020-0028_ref_008","doi-asserted-by":"crossref","unstructured":"Shimohata H, Maruyama H, Miyamoto Y, Takayasu M, Hirayama K, Kobayashi M. Urinary mulberry cells and mulberry bodies are useful tool to detect late-onset Fabry disease. CEN Case Rep 2017;6:148\u201351. https:\/\/doi.org\/10.1007\/s13730-017-0262-5.","DOI":"10.1007\/s13730-017-0262-5"},{"key":"2023062110014636358_j_almed-2020-0028_ref_009","doi-asserted-by":"crossref","unstructured":"Yano T, Takahashi R, Yamashita T, Nagano N, Ishikawa A, Sakurai A, et al. Detection of urinary mulberry bodies leads to diagnosis of Fabry cardiomyopathy. Circ Hear Fail 2017;10:1\u20134. https:\/\/doi.org\/10.1161\/circheartfailure.117.004538.","DOI":"10.1161\/CIRCHEARTFAILURE.117.004538"}],"container-title":["Advances in Laboratory Medicine \/ Avances en Medicina de Laboratorio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/almed\/1\/3\/article-20200028.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/almed-2020-0028\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/almed-2020-0028\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T10:02:46Z","timestamp":1687341766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/almed-2020-0028\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,9,22]]},"published-print":{"date-parts":[[2020,10,6]]}},"alternative-id":["10.1515\/almed-2020-0028"],"URL":"https:\/\/doi.org\/10.1515\/almed-2020-0028","relation":{},"ISSN":["2628-491X"],"issn-type":[{"type":"electronic","value":"2628-491X"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"article-number":"20200028"}}