{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:15:27Z","timestamp":1766391327661},"reference-count":6,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_almed-2022-0046_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>It is estimated that 29% of patients treated with sulfadiazine ultimately develop acute kidney failure. Diagnosis is based on urine sediment analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0046_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 71-year-old woman with loss of visual acuity in the context of a flare of systemic erythematosus lupus (SEL). A diagnosis of acute retinal necrosis was established, pending etiological confirmation. Empirical treatment with sulfadiazine was initiated. Follow-up analyses included urine sediment, which revealed pH 6, 30\u201350 RBCs\/field, urothelial cells and lower tract epithelial cells, hyaline casts, fatty casts or Maltese cross, and abundant sulfadiazine crystals. The finding was reported to the Unit of Nephrology, and treatment was immediately suspended.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0046_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sulfadiazine is an antibiotic of the family of sulfamides. Crystalization of sulfadiazine in the renal tubules may cause acute interstitial nephritis. These crystals adopt different shapes according to the metabolite that crystalizes: unaltered forms precipitate into dense, globular crystals, whereas in other cases, as in the case reported in this paper, crystals adopt a fan-shaped, shocks-of-wheat morphology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/almed-2022-0046","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T17:25:28Z","timestamp":1655400328000},"page":"210-211","source":"Crossref","is-referenced-by-count":1,"title":["Sulfadiazine crystalluria in a patient with lupus nephritis"],"prefix":"10.1515","volume":"3","author":[{"given":"Maria Jes\u00fas","family":"Ruiz \u00c1lvarez","sequence":"first","affiliation":[{"name":"Service of Clinical Biochemistry , Hospital Universitario Pr\u00edncipe de Asturias , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Molina Blas","sequence":"additional","affiliation":[{"name":"Service of Clinical Biochemistry , Hospital Universitario Pr\u00edncipe de Asturias , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Barrionuevo Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Service of Clinical Biochemistry , Hospital Universitario Pr\u00edncipe de Asturias , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eugenia","family":"Pe\u00f1as Lorite","sequence":"additional","affiliation":[{"name":"Service of Clinical Biochemistry , Hospital Universitario Pr\u00edncipe de Asturias , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Gasalla Herraiz","sequence":"additional","affiliation":[{"name":"Service of Clinical Biochemistry , Hospital Universitario Pr\u00edncipe de Asturias , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"2023062110202155287_j_almed-2022-0046_ref_001","unstructured":"Lorenzo, FP, Moreno, GA, Leza, CJ, Lizasoain, HI, Vel\u00e1zquez, MSM. Farmacolog\u00eda b\u00e1sica y cl\u00ednica, 19a ed. Madrid: Panamericana; 2018."},{"key":"2023062110202155287_j_almed-2022-0046_ref_002","unstructured":"Bennet, J, Dolin, R, Blaser, M. Bennett, J, Dolin, R, Blaser, MJ, editors. Mandell, Douglas, Bennett. Enfermedades infecciosas. Principios y pr\u00e1ctica, 9a ed USA: Principios y pr\u00e1ctica; 2020."},{"key":"2023062110202155287_j_almed-2022-0046_ref_003","unstructured":"Farreras, A, Rozman, P, Nicol\u00e1s, F, Cervera, J, Agust, R. Medicina interna, 19a ed Barcelona: Duran Rebolledo; 2020."},{"key":"2023062110202155287_j_almed-2022-0046_ref_004","unstructured":"Ravelo, MA., Mediavilla, SP, Campos Noceda, NO. Detecci\u00f3n precoz de cristales de sulfadiazina en orina. Lab Med at a glance 2020;14:15."},{"key":"2023062110202155287_j_almed-2022-0046_ref_005","doi-asserted-by":"crossref","unstructured":"Garc\u00eda de Cruz, S, Cores, CO, Bueno, AC, Pe\u00f1a, BC. Da\u00f1o renal agudo por sulfadiacina en paciente con toxoplasmosis oft\u00e1lmica. Rev del Lab Clin 2011;4:160\u20132. https:\/\/doi.org\/10.1016\/j.labcli.2011.06.002.","DOI":"10.1016\/j.labcli.2011.06.002"},{"key":"2023062110202155287_j_almed-2022-0046_ref_006","doi-asserted-by":"crossref","unstructured":"Daudon, M, Frochot, V, Bazin, D, Jungers, P. Drug-induced kidney stones and crystalline nephropathy: pathophysiology, prevention and treatment. Drugs; 2017. https:\/\/doi.org\/10.1007\/s40265-017-0853-7.","DOI":"10.1007\/s40265-017-0853-7"}],"container-title":["Advances in Laboratory Medicine \/ Avances en Medicina de Laboratorio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/almed-2022-0046\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/almed-2022-0046\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T10:21:52Z","timestamp":1687342912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/almed-2022-0046\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,2]]},"published-print":{"date-parts":[[2022,6,30]]}},"alternative-id":["10.1515\/almed-2022-0046"],"URL":"https:\/\/doi.org\/10.1515\/almed-2022-0046","relation":{},"ISSN":["2628-491X"],"issn-type":[{"value":"2628-491X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}