{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:33:10Z","timestamp":1789475590314,"version":"build-2803163510"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_almed-2022-0088_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Bilateral inferior petrosal sinus sampling (BIPSS) is a useful test for differential diagnosis of central vs. ectopic adrenocorticotropic hormone (ACTH)-dependent Cushing\u2019s syndrome (CS). We provide a description of the protocol used in our Center and an analysis of its diagnostic accuracy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0088_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective study was conducted of 28 patients who underwent BIPSS combined with corticotropin-releasing hormone (CRH) stimulation. The procedure is performed in an interventional neuroradiology suite, involving a multidisciplinary team of neuroradiologists, endocrinologists and laboratory professionals. The two petrosal sinuses are catheterized and a peripheral blood sample is obtained simultaneously, at baseline and at 3, 6 and 10\u00a0min following stimulation. ACTH and prolactin are determined by immunochemiluminescence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0088_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 19 cases of Cushing\u2019s disease (CD) and 1 case of ectopic CS were confirmed. In all cases, BIPSS provided accurate diagnostic guidance, with a sensitivity and specificity of 100%. In 8 patients, remission was not achieved after surgery. In 84% of catheterizations, ACTH ratio peaked at 3\u20136\u00a0min following stimulation. Patients with histologically-confirmed CD exhibited higher sinus ACTH ratios and values. Prolactin ratio helped us identify and exclude 28.6% of the samples with inconsistent results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0088_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our series, BIPSS combined with CRH stimulation demonstrated to be a safe, effective procedure. Prolactin emerges as a useful marker of correct catheterization. The participation of a multidisciplinary team is essential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/almed-2022-0088","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T08:20:28Z","timestamp":1664612428000},"page":"282-287","source":"Crossref","is-referenced-by-count":2,"title":["Bilateral inferior petrosal sinus sampling in the diagnosis of ACTH-dependent Cushing\u2019s syndrome: experience in a tertiary hospital"],"prefix":"10.1515","volume":"3","author":[{"given":"Isabel","family":"Moreno Parro","sequence":"first","affiliation":[{"name":"Laboratory Medicine Department , La Paz University Hospital-Carlos III-Cantoblanco , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ortiz S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Department , La Paz University Hospital-Carlos III-Cantoblanco , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Garc\u00eda Moreno","sequence":"additional","affiliation":[{"name":"Endocrinology Department , La Paz University Hospital-Carlos III-Cantoblanco , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-0427","authenticated-orcid":false,"given":"Rub\u00e9n","family":"G\u00f3mez Rioja","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Department , La Paz University Hospital-Carlos III-Cantoblanco , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remedios","family":"Frutos Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Radiology Department , La Paz University Hospital-Carlos III-Cantoblanco , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"\u00c1lvarez-Escol\u00e1","sequence":"additional","affiliation":[{"name":"Endocrinology Department , La Paz University Hospital-Carlos III-Cantoblanco , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023062110183698236_j_almed-2022-0088_ref_001","unstructured":"Endotext. Cushing\u2019s syndrome; Updated 2021. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279088\/."},{"key":"2023062110183698236_j_almed-2022-0088_ref_002","doi-asserted-by":"crossref","unstructured":"Santos, S, Santos, E, Gaztambide, S, Salvador, J. Diagn\u00f3stico y diagn\u00f3stico diferencial del s\u00edndrome de Cushing. Endocrinol Nutr 2009;56:71\u201384. https:\/\/doi.org\/10.1016\/s1575-0922(09)70555-8.","DOI":"10.1016\/S1575-0922(09)70555-8"},{"key":"2023062110183698236_j_almed-2022-0088_ref_003","doi-asserted-by":"crossref","unstructured":"Zampetti, B, Grossrubatscher, E, Dalino Ciaramella, P, Boccardi, E, Loli, P. Bilateral inferior petrosal sinus sampling. Endocr Connect 2016;5:R12\u201325. https:\/\/doi.org\/10.1530\/ec-16-0029.","DOI":"10.1530\/EC-16-0029"},{"key":"2023062110183698236_j_almed-2022-0088_ref_004","doi-asserted-by":"crossref","unstructured":"Giuffrida, G, Crisafulli, S, Ferra\u00f9, F, Fontana, A, Alessi, Y, Calapai, F, et al.. 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