{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:38:38Z","timestamp":1785893918232,"version":"3.56.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_almed-2022-0111_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The central nervous system (CNS) is essential for homeostasis and controls the physiological functions of the body. However, the biochemical characteristics of the CNS make it especially vulnerable to oxidative damage (OS). This phenomenon compromises correct CNS functioning, leading to neurodegeneration and neuronal death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0111_abs_002\">\n                  <jats:title>Contents<\/jats:title>\n                  <jats:p>OS plays a crucial role in the physiopathology of neurodegenerative diseases. It is involved in multiple mechanisms of nucleic acid, protein, and lipid oxidation, thereby contributing to progressive brain damage. These mechanisms include mitochondrial dysfunction; excessive production of reactive oxygen and nitrogen species; deficiency of antioxidant defenses; protein oligomerization; cytokine production and inflammatory response; blood\u2013brain barrier abnormalities; and proteasome dysfunction. All these dysfunctions are involved in the pathogenesis of\u00a0neurodegenerative diseases, including Parkinson\u2019s disease, Alzheimer\u2019s disease, Huntington\u2019s disease, or amyotrophic lateral sclerosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2022-0111_abs_003\">\n                  <jats:title>Summary and outlook<\/jats:title>\n                  <jats:p>A curative treatment is currently not available. Research is focused on the search for therapies that reduce oxidative damage and delay disease progression. In the recent years, researchers have focused their attention on the effects of antioxidant therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/almed-2022-0111","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T23:50:23Z","timestamp":1671234623000},"page":"342-350","source":"Crossref","is-referenced-by-count":40,"title":["The role of oxidative stress in neurodegenerative diseases and potential antioxidant therapies"],"prefix":"10.1515","volume":"3","author":[{"given":"Paula","family":"Sienes Bailo","sequence":"first","affiliation":[{"name":"Servicio de Bioqu\u00edmica Cl\u00ednica , Hospital Universitario\u00a0Miguel Servet , Zaragoza , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n (IIS Arag\u00f3n) , Zaragoza , Spain"},{"name":"Sociedad Espa\u00f1ola de Medicina de Laboratorio (SEQC-ML) , Comisi\u00f3n de Estr\u00e9s Oxidativo , Barcelona , 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