{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:48:10Z","timestamp":1747198090088,"version":"3.40.5"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_almed-2024-0115_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Exhaled breath tests (BTs) are the main diagnostic method for fructose and lactose malabsorption\/intolerance (FI and LI, respectively) and for detecting small intestine bacterial or methanogen overgrowth (SIBO\/IMO). Although FI\/LI-BTs may provide evidence of the presence of SIBO\/IMO, there is limited literature evaluating their reliability for this purpose. The objective of this study was to assess the sensitivity and specificity of FI\/LI-BTs in detecting SIBO and their concordance with SIBO-BTs in the identification of IMO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2024-0115_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this retrospective observational study, FI\/LI-BTs and SIBO-BTs performed in the same patients within a period of 6\u00a0weeks were selected from 652 gas chromatography-based BTs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2024-0115_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 146 BTs from 67 eligible adult patients were identified. LI-BTs had higher specificity than FI-BT in detecting SIBO (93.8\u202f% vs. 72.7\u202f%). In contrast, FI-BTs showed higher sensitivity (60.0\u202f% vs. 28.6\u202f%) as FI was more frequently established in SIBO-positive patients (70\u202f% vs. 29\u202f%). With regard to IMO, concordance with LI-BT was 100\u202f%, with a 27\u202f% of false negatives on FI-BTs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_almed-2024-0115_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Findings suggestive of SIBO or IMO on LI-BTs were highly consistent with those of SIBO-BTs. In contrast, the rate of false positives for SIBO and the rate of false negative for IMO on FI-BTs was 27\u202f% in both cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/almed-2024-0115","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T15:40:29Z","timestamp":1723131629000},"page":"327-332","source":"Crossref","is-referenced-by-count":0,"title":["Detection capacity of small intestine bacterial or methanogen overgrowth by lactose and fructose breath testing in the adult population"],"prefix":"10.1515","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-7667","authenticated-orcid":false,"given":"Emilio Jos\u00e9","family":"Laserna Mendieta","sequence":"first","affiliation":[{"name":"Gastroenterology Research Unit , Hospital General de Tomelloso , Tomelloso , Ciudad Real , Spain"},{"name":"Service of Clinical Laboratory , Hospital Universitario La Princesa , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM) , Toledo , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-2707","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Mart\u00edn Dominguez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa , Madrid , Spain"},{"name":"Department of Gastroenterology , Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-7715","authenticated-orcid":false,"given":"Irene","family":"P\u00e9rez Lucendo","sequence":"additional","affiliation":[{"name":"Service of Clinical Laboratory , Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Granero Cremades","sequence":"additional","affiliation":[{"name":"Service of Clinical Laboratory , Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-1449","authenticated-orcid":false,"given":"Raquel","family":"Ferreir\u00f3s Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Service of Clinical Laboratory , Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0713-4285","authenticated-orcid":false,"given":"Tom\u00e1s","family":"\u00c1lvarez Mal\u00e9","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa , Madrid , Spain"},{"name":"Department of Gastroenterology , Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Sanz De Benito","sequence":"additional","affiliation":[{"name":"Service of Clinical Laboratory , Hospital Universitario La Princesa , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-2535","authenticated-orcid":false,"given":"Cecilio","family":"Santander","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa , Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid , Spain"},{"name":"Department of Gastroenterology , Hospital Universitario La Princesa , Madrid , Spain"},{"name":"Department of Medicine , Universidad Aut\u00f3noma de Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"2024090606221701302_j_almed-2024-0115_ref_001","doi-asserted-by":"crossref","unstructured":"Pimentel, M, Saad, RJ, Long, MD, Rao, SSC. 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