{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:45:50Z","timestamp":1774352750465,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The paper presents an overview of the use of natural therapeutic agents in combating parasitic diseases. Nowadays there is increasing demand for proven plant therapies, which often are found to be more effective than synthetic pharmaceuticals in chronic diseases. In many cases herbal preparations perfectly supplement the conventional treatment and at the same time do not cause side effects. On the pharmaceutical market there are many drugs of plant origin which have been applied in the treatment of parasitic diseases. However, researchers are still looking for new plants, or specific substances isolated from them, which can be used in therapy. In this paper, drugs of plant origin used in the treatment of amoebiasis, giardiasis, malaria, leishmaniasis, trypanosomiasis and acanthamoebiasis are described.<\/jats:p>","DOI":"10.1515\/ap-2015-0001","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T09:27:21Z","timestamp":1429522041000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["The use of phytotherapy in diseases caused by parasitic protozoa"],"prefix":"10.1007","volume":"60","author":[{"given":"Monika","family":"Derda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Hada\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref241","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1007\/s00436-011-2744-2","article-title":"In vitro amoebicidal activities of Satureja cuneifolia and Melissa officinalis on Acanthamoeba castellanii cyst and trophozoites","volume":"110","author":"Malatyali","year":"2012","journal-title":"Parasitology Research"},{"key":"ref321","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1007\/s00436-011-2798-1","article-title":"de Anti - Trichomonas vaginalis activity of saponins from Quillaja and Ilex species","volume":"110","author":"Rocha","year":"2012","journal-title":"Parasitology Research"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00436-010-1988-6","article-title":"de Croton cajucara crude extract and isolated terpenes : activity on Trypanosoma cruzi","author":"Campos","year":"2010","journal-title":"Parasitology Research"},{"key":"ref391","first-page":"102","article-title":"Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides","author":"Shuaibu","year":"2008","journal-title":"Parasitology Research"},{"key":"ref51","first-page":"163","article-title":"Chemopreventive effect of punicalagin , a novel tannin component isolated from Terminalia catappa , on hras - transformed NIH cells","author":"Chen","year":"2006","journal-title":"Toxicology Letters"},{"key":"ref331","first-page":"41","article-title":"Comparison of Pouzolzia indica methanolic extract and Virkon against cyst of Acanthamoeba spp","author":"Roongruangchai","year":"2010","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1128\/AAC.46.4.1026-1031.2002","article-title":"Artemisinin pharmacokinetics and efficacy in uncomplicatedmalaria patients treated with two different dosage regimens","author":"Gordi","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref521","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1055\/s-0030-1250548","article-title":"Improved traditional phytomedicines in current use for the clinical treatment of malaria","author":"Willcox","year":"2011","journal-title":"Planta Medica"},{"key":"ref421","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1128\/CMR.16.4.713-729","article-title":"Laboratory Diagnosis of Amebiasis","author":"Tanyuksel","year":"2003","journal-title":"Clinical Microbiology Reviews"},{"key":"ref441","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jep.2011.10.035","article-title":"Via Ethnopharmacological survey of Annonaceae medicinal plants used to treat malaria in four areas of Cameroon","author":"Tsabang","year":"2012","journal-title":"Journal of Ethnopharmacology"},{"key":"ref451","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00436-012-2834-9","article-title":"In vitro antiplasmodial activity of some traditionally used medicinal plants against Plasmodium falciparum","author":"Venkatesalu","year":"2012","journal-title":"Parasitology Research"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00436-009-1700-x","article-title":"Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan : too early for too much hope","author":"Giha","year":"2010","journal-title":"Parasitology Research"},{"key":"ref161","first-page":"67","article-title":"Experimental studies on artemisia , a herbal remedy for malaria","author":"Gulati","year":"1996","journal-title":"Fitoterapia"},{"key":"ref531","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1136\/bmj.329.7475.1156","article-title":"Traditional herbal medicines for malaria","author":"Willcox","year":"2004","journal-title":"British Medical Journal"},{"key":"ref411","first-page":"106","article-title":"de do A review of antimalarial plants used in traditional medicine in communities in Portuguese - speaking countries : Sao Tome and Principe and Angola do","author":"Silva","year":"2011","journal-title":"Memorias Instituto Oswaldo Cruz"},{"key":"ref101","first-page":"70","article-title":"The evaluation of the amebicidal activity of Eryngium planum extracts","author":"Derda","year":"2013","journal-title":"Acta Poloniae Pharmaceutica"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00436-011-2787-4","article-title":"dos da da da First raport of anti - Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi - arid region , Caatinga","author":"Frasson","year":"2012","journal-title":"Parasitology Research"},{"key":"ref31","first-page":"996","article-title":"Structure biosynthesis and functions of artemisinin","author":"Bharel","journal-title":"Fitoterapia"},{"key":"ref01","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jep.2010.11.024","article-title":"Potential antimalarials from Nigerian plants : a review","author":"Adebayo","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"ref231","first-page":"21","article-title":"Antioxidant and free radical scavenging effects of the tannins of Terminalia catappa L","author":"Lin","year":"2001","journal-title":"Anticancer Research"},{"key":"ref291","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00436-012-2861-6","article-title":"b Metabolites from the leaf extract of Serjania yucatanensis with trypanocidal activity against Trypanosoma cruzi","author":"Polanco","year":"2012","journal-title":"Parasitology Research"},{"key":"ref281","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00436-011-2447-8","article-title":"Moo a In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula","volume":"110","author":"Polanco","year":"2012","journal-title":"Parasitology Research"},{"key":"ref91","first-page":"81","article-title":"Tanacetum vulgare as a plant with potential medicinal properties for Acanthamoeba keratitis","author":"Derda","year":"2012","journal-title":"Nowiny Lekarskie"},{"key":"ref311","first-page":"66","article-title":"de In vitro evaluation of the amebicidal activity of Buddleia cordata Loganiaceae on several strains of Acanthamoeba","author":"Rodriguez","year":"1999","journal-title":"Journal of Ethnopharmacology"},{"key":"ref431","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s00436-011-2698-4","article-title":"In vitro amoebicidal activities of Teucrium polium and T chamaedrys on Acanthamoeba castellanii trophozoites and cyst","volume":"110","author":"Tepe","year":"2012","journal-title":"Parasitology Research"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.fitote.2005.04.009","article-title":"In vitro antiprotozoal activity of the leaves of Artemisia ludoviciana","volume":"76","author":"Said Fernandez","year":"2005","journal-title":"Fitoterapia"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.phymed.2012.09.011","article-title":"Trypanocidal activity of guaianolide obtained from Tanacetum Parthenium Bip and its combinational effect with benznidazole","author":"Cogo","year":"2012","journal-title":"Phytomedicine"},{"key":"ref191","first-page":"90","article-title":"b Formulation and biopharmaceutical issues in the development of drug delivery systems for antiparasitic drugs","author":"Kayser","year":"2003","journal-title":"Parasitology Research"},{"key":"ref541","doi-asserted-by":"publisher","first-page":"543216","DOI":"10.1155\/2011\/543216","article-title":"Zingiber zerumbet A review of its ethnomedicinal chemical , and pharmacological uses Evidence - Based Complementary and Alternative","author":"Yob","year":"2011","journal-title":"Medicine"},{"key":"ref461","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00436-012-2918-6","article-title":"von Chemical composition and amoebicidal activity of Croton pallidulus , Croton ericoides , and Croton isabelli Euphorbiaceae essential oils","author":"Vunda","year":"2012","journal-title":"Parasitology Research"},{"key":"ref21","first-page":"72","article-title":"Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun","author":"Arrieta","year":"2001","journal-title":"Fitoterapia"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/0035-9203(90)90012-4","article-title":"A randomized comparative study of artemisinine suppositories and oral quinine in acute falciparum Malaria Transactions of the","author":"Arnold","year":"1990","journal-title":"Royal Society of Tropical Medicine and Hygiene"},{"key":"ref121","first-page":"75","article-title":"Phytochemical and antiinflammatory studies on Terminalia catappa","author":"Fan","year":"2004","journal-title":"Fitoterapia"},{"key":"ref181","first-page":"90","article-title":"a Natural products as antiparasitic drugs","author":"Kayser","year":"2003","journal-title":"Parasitology Research"},{"key":"ref361","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00436-011-2383-7","article-title":"dos von Amoebicidal activity and chemical composition of Pterocaulon polystachyum Asteraceae essential oil","volume":"109","author":"Sauter","year":"2011","journal-title":"Parasitology Research"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00436-011-2727-3","article-title":"In vitro amoebicidal activity of ethanol extracts of Arachis hypogaea Curcuma and Pancratium maritimum on Acanthamoeba castellanii cysts","author":"El","year":"2012","journal-title":"Parasitology Research"},{"key":"ref301","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s00436-008-1186-y","article-title":"da von In vitro evaluation of the amebicida activity of Pterocaulon polystachyum Asteraceae against trophozoites of Acanthamoeba castellanii","author":"Rodio","year":"2008","journal-title":"Parasitology Research"},{"key":"ref381","first-page":"98","article-title":"The anti - amoebic activity of some medicinal plants used by AIDS patients in southern Thailand","author":"Sawangjaroen","year":"2006","journal-title":"Parasitology Research"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00436-011-2456-7","article-title":"In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants","volume":"110","author":"Kemgne","year":"2012","journal-title":"Parasitology Research"},{"key":"ref261","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00436-010-2091-8","article-title":"dos Anti - leismanial effects of purified compounds from aerial parts of Baccharis uncinella )","volume":"108","author":"Passero","year":"2011","journal-title":"Parasitology Research"},{"key":"ref401","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.parint.2010.08.005","article-title":"da Antileishmanial activity of a guaianolide from Tanacetum parthenium","author":"Silva","year":"2010","journal-title":"Parasitology International"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1074\/jbc.M109.005843.","article-title":"The antimalarial drug quinine disrupts Tat p - mediated tryptophan transport and causes tryptophan starvation","author":"Khozoie","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1086\/524888","article-title":"Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening","author":"Cox","year":"2008","journal-title":"Clinical Infectious Diseases"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s00436-008-1277-9","article-title":"Plant extracts as natural amoebicidal agents","author":"Derda","year":"2009","journal-title":"Parasitolology Research"},{"key":"ref511","first-page":"98","article-title":"Giardiosis - clinical manifestations , diagnosis and therapy","volume":"2","author":"Wierci\u0144ska","year":"2010","journal-title":"Gastroenterologia Kliniczna"},{"key":"ref251","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1472-6882-13-147","article-title":"Cameroonian medicinal plants : a bioactivity versus ethnobotanical survey and chemotaxonomic classification and","author":"Ntie","year":"2013","journal-title":"BMC Complementary Alternative Medicine"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1186\/1475-2875-11-382","article-title":"Compounds from Sorindeia juglandifolia Anacardiaceae exhibit potent anti - plasmodial activities in vitro and in vivo","volume":"21","author":"Kamkumo","year":"2012","journal-title":"Malaria Journal"},{"key":"ref371","first-page":"95","article-title":"The in vitro anti - giardial activity of extracts from plants that are used for self - medication by AIDS patients in southern Thailand","author":"Sawangjaroen","year":"2005","journal-title":"Parasitology Research"}],"container-title":["Acta Parasitologica"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/j\/ap.2015.60.issue-1\/ap-2015-0001\/ap-2015-0001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T16:39:44Z","timestamp":1607963984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/view\/j\/ap.2015.60.issue-1\/ap-2015-0001\/ap-2015-0001.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":48,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/ap-2015-0001","relation":{},"ISSN":["1896-1851"],"issn-type":[{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}